1.
Bioorg Med Chem Lett
; 23(9): 2759-64, 2013 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23518278
RESUMO
The synthesis and inhibitory potencies of a novel series of 3,5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3,5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried out previously and found to inhibit the growth of Mycobacterium tuberculosis.