Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.

BACKGROUND: Temporomandibular joint osteoarthritis is a common degenerative joint disease. This disease negatively affects the daily life, speech and chewing functions of patients. OBJECTIVE: This study aimed to evaluate the effects of intra-articular injection of alendronate to osteoarthritis, which has a protective effect on bone and cartilage tissue and helps reduce inflammation in temporomandibular joint osteoarthritis. METHODS: A total of 24 Wistar albino rats were used in the study. Rats were divided into four groups: study, saline, control and sham. In both saline and control groups, monosodium iodoacetate was injected intra-articularly to induce osteoarthritis. Alendronate was administered intra-articularly to the study group weekly for 4 weeks. In the saline group, saline was administered by intra-articular injection. At the end of the 12th week, all groups were sacrificed. Mandibular condyle tissues were examined histopathologically. RESULTS: According to the results, osteoarthritic changes in the control group were higher than those in the study group (p < .05). No significant reduction in osteoarthritic changes was observed in the saline group (p > .05). Significant osteoarthritis findings were observed in all groups compared with the sham group (p < .05). CONCLUSION: Intra-articular injection of alendronate was found to have positive results on TMJ osteoarthritis. In addition, it was seen that alendronate has effects on reducing cartilage tissue degeneration and loss of matrix proteins.

Analyses of Youtube Videos on Botox Treatment of Gummy Smile.

OBJECTIVE: The purpose of this study was to determine the content quality and accuracy of the YouTube videos about the Botox application during gummy smile treatment and to analyze the efficacy of these videos in informing the healthcare professionals and the patients. MATERIALS AND METHODS: The first 200 videos resulting from the search on YouTube by using the keywords "gummy smile/Botox," which were determined by Google Trends, were evaluated in the study. One hundred fourteen out of these 200 videos were included in the study. The videos were calculated using these descriptive features. A content scale consisting of 8 categories was used to determine the content levels of the videos and the video information and quality index scale was used to determine the quality level. RESULTS: The most mentioned subjects in the videos were "Description" of the gummy smile and Botox treatment (71.9%), "Advantage" of Botox treatment (51.8%), "Procedure" (48.2%), and "Prognosis" (47.4%). The "Contraindication" was mentioned rarely (2.6%). A statistically significant difference was found between the videos with different content levels in terms of Description, Advantage, indication, Procedure, Complication, Prognosis, and Cost. Likewise, there was a statistically significant difference between videos in distinct content level groups in terms of video information and quality index total score. CONCLUSIONS: The quality of the YouTube videos about Botox applications in gummy smile treatment was found to be low in general. it is important for the physician who will perform the procedure to explain the procedure to the patients in detail. in addition, YouTube was determinedto be insufficient for accessing high-quality information for students, assistants, and specialist physicians.