RESUMO
We compared the duration of antimicrobial effectiveness of 2 different antimicrobial catheters. The baseline activity of minocycline-rifampin catheters was greater than that of silver-platinum-carbon catheters against Staphylococcus aureus, Staphylococcus epidermidis, and Enterococcus faecalis. The antimicrobial activity of the minocycline-rifampin catheters against these pathogens persisted for up to 12 days, while that of the silver-platinum-carbon catheters was depleted by day 10 (P < .05).
Assuntos
Cateterismo Venoso Central/instrumentação , Cateteres de Demora/microbiologia , Bactérias Gram-Positivas/efeitos dos fármacos , Anti-Infecciosos/farmacologia , Aderência Bacteriana/efeitos dos fármacos , Cateterismo Venoso Central/efeitos adversos , Bactérias Gram-Positivas/crescimento & desenvolvimento , Massachusetts , Minociclina/farmacologia , Rifampina/farmacologiaRESUMO
This report describes the safety observations following administration of a polyvalent DNA prime-protein boost HIV-1 vaccine formulated with adjuvant QS21. Local injection site reactions were the most common (65% of subjects), and included type IV delayed-type hypersensitivity (DTH) reactions at prior DNA inoculation sites in 12 of 28 (43%) subjects following protein vaccination. Systemic reactions revealed two cases of vasculitis temporally related to inoculation with recombinant Env protein+QS21 adjuvant. Questions remain regarding the cause of the vasculitis, but the unique DTH observation may have contributed to the high level of immune responses previously reported for this vaccine.