RESUMO
BACKGROUND: Neonatal cholestasis syndrome (NCS) is a major cause of morbidity and mortality in infants. The disorder has rarely been studied in centers from Central India. OBJECTIVES: To study the prevalence, clinical presentation and etiology of NCS at a tertiary referral center in Central India. MATERIALS AND METHODS: The study was carried out at a tertiary referral center in Central India. The study is a descriptive study. The records of all patients with suspected NCS treated in the Department of Pediatrics from 2007-2012 were analyzed. RESULTS: One hundred and sixty-eight children had a provisional diagnosis of NCS. The complete records of 100 children were available for the study. The median age of presentation was 78 days (range 15-270 days). The male: female ratio was 1.17:1. The clinical features noted were- jaundice (100/100,100%), failure to thrive (73,73%), organomegaly (68, 68%), acholic stools (38,38%), abdominal distention (52,52%) and poor feeding (29, 29%). The etiology as confirmed by investigations is as follows- neonatal hepatitis (20,20%), idiopathic neonatal hepatitis (18,18%), biliary atresia (41,41%), sepsis (14,14%) and others (7,7%). CONCLUSIONS: The proportion of NCS in our group of patients was 1.2 per 1000 patients. Jaundice, organomegaly and failure to thrive are the common presentations. Biliary atresia, neonatal hepatitis and idiopathic neonatal hepatitis were the common etiological factors at our center.
Assuntos
Antivirais/uso terapêutico , Hepatite B Crônica/tratamento farmacológico , Cooperação do Paciente/psicologia , Cooperação do Paciente/estatística & dados numéricos , Adulto , Idoso , Antivirais/efeitos adversos , Antivirais/economia , Custos e Análise de Custo , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Educação de Pacientes como Assunto , Inquéritos e Questionários , Resultado do TratamentoAssuntos
Infecções por Escherichia coli/epidemiologia , Cirrose Hepática/complicações , Dermatopatias Bacterianas/epidemiologia , Infecções Cutâneas Estafilocócicas/epidemiologia , Adulto , Infecções por Escherichia coli/etiologia , Pé , Humanos , Hospedeiro Imunocomprometido , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Albumina Sérica , Dermatopatias Bacterianas/etiologia , Infecções Cutâneas Estafilocócicas/etiologia , Caminhada , Adulto JovemAssuntos
Deficiência de Glucosefosfato Desidrogenase/complicações , Hepatite A/complicações , Hepatite E/complicações , Doença Aguda , Adolescente , Adulto , Bilirrubina/sangue , Creatinina/sangue , Feminino , Deficiência de Glucosefosfato Desidrogenase/terapia , Hepatite A/terapia , Hepatite E/terapia , Humanos , Coeficiente Internacional Normatizado , Tempo de Internação , Masculino , Diálise Renal , Estudos Retrospectivos , Adulto JovemRESUMO
In this retrospective study, the records of all patients diagnosed with inflammatory bowel disease between 2005 and 2010 were analysed. Ulcerative colitis is far more common than Crohn's disease in our setting. The incidence is similar in both sexes and the age at diagnosis for both is similar. Limited left-sided ulcerative colitis is more common. Crohn's disease is difficult to diagnose and is commonly treated as tuberculosis in our setting.
Assuntos
Colite Ulcerativa/epidemiologia , Doença de Crohn/epidemiologia , Adulto , Colite Ulcerativa/diagnóstico , Doença de Crohn/diagnóstico , Diagnóstico Tardio , Feminino , Humanos , Incidência , Índia/epidemiologia , Masculino , Estudos RetrospectivosRESUMO
The aim of this study was to look at the aetiological factors presenting as acute febrile illness in cirrhotic patients. The study group included all cirrhotic patients admitted as inpatients between January and December 2011 with a history of fever of less than seven days duration. Detailed history, clinical examination and investigations, as required, were noted. The data collected were analysed. A total of 42 patients formed the study group. The male-to-female ratio was 9.5:1. The mean age at presentation was 45.09 years (24-77 years). The aetiological factors for fever were: spontaneous bacterial peritonitis (20), lower respiratory tract infection (8), urinary tract infection (6), lower limb cellulitis (4), acute cholecystitis (2) and malaria (2). The mean MELD (model for end-stage liver disease) score at presentation was 20.4. Three patients with spontaneous bacterial peritonitis (SBP) and a mean MELD score of 31 died during the hospital admission. Febrile illness in cirrhosis is attributable to multiple causes. Outcome is dependent on the severity of underlying liver disease.