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1.
bioRxiv ; 2024 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-38826245

RESUMO

Purpose: To develop multichannel transmit and receive arrays towards capturing the ultimate-intrinsic-SNR (uiSNR) at 10.5 Tesla (T) and to demonstrate the feasibility and potential of whole-brain, high-resolution human brain imaging at this high field strength. Methods: A dual row 16-channel self-decoupled transmit (Tx) array was converted to a 16Tx/Rx transceiver using custom transmit/receive switches. A 64-channel receive-only (64Rx) array was built to fit into the 16Tx/Rx array. Electromagnetic modeling and experiments were employed to define safe operation limits of the resulting 16Tx/80Rx array and obtain FDA approval for human use. Results: The 64Rx array alone captured approximately 50% of the central uiSNR at 10.5T while the identical 7T 64Rx array captured ∼76% of uiSNR at this lower field strength. The 16Tx/80Rx configuration brought the fraction of uiSNR captured at 10.5T to levels comparable to the performance of the 64Rx array at 7T. SNR data obtained at the two field strengths with these arrays displayed dependent increases over a large central region. Whole-brain high resolution T 2 * and T 1 weighted anatomical and gradient-recalled echo EPI BOLD fMRI images were obtained at 10.5T for the first time with such an advanced array, illustrating the promise of >10T fields in studying the human brain. Conclusion: We demonstrated the ability to approach the uiSNR at 10.5T over the human brain with a novel, high channel count array, achieving large SNR gains over 7T, currently the most commonly employed ultrahigh field platform, and demonstrate high resolution and high contrast anatomical and functional imaging at 10.5T.

2.
Magn Reson Med ; 92(3): 1219-1231, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38649922

RESUMO

PURPOSE: We examined magnetic field dependent SNR gains and ability to capture them with multichannel receive arrays for human head imaging in going from 7 T, the most commonly used ultrahigh magnetic field (UHF) platform at the present, to 10.5 T, which represents the emerging new frontier of >10 T in UHFs. METHODS: Electromagnetic (EM) models of 31-channel and 63-channel multichannel arrays built for 10.5 T were developed for 10.5 T and 7 T simulations. A 7 T version of the 63-channel array with an identical coil layout was also built. Array performance was evaluated in the EM model using a phantom mimicking the size and electrical properties of the human head and a digital human head model. Experimental data was obtained at 7 T and 10.5 T with the 63-channel array. Ultimate intrinsic SNR (uiSNR) was calculated for the two field strengths using a voxelized cloud of dipoles enclosing the phantom or the digital human head model as a reference to assess the performance of the two arrays and field depended SNR gains. RESULTS: uiSNR calculations in both the phantom and the digital human head model demonstrated SNR gains at 10.5 T relative to 7 T of 2.6 centrally, ˜2 at the location corresponding to the edge of the brain, ˜1.4 at the periphery. The EM models demonstrated that, centrally, both arrays captured ˜90% of the uiSNR at 7 T, but only ˜65% at 10.5 T, leading only to ˜2-fold gain in array SNR in going from 7 to 10.5 T. This trend was also observed experimentally with the 63-channel array capturing a larger fraction of the uiSNR at 7 T compared to 10.5 T, although the percentage of uiSNR captured were slightly lower at both field strengths compared to EM simulation results. CONCLUSIONS: Major uiSNR gains are predicted for human head imaging in going from 7 T to 10.5 T, ranging from ˜2-fold at locations corresponding to the edge of the brain to 2.6-fold at the center, corresponding to approximately quadratic increase with the magnetic field. Realistic 31- and 63-channel receive arrays, however, approach the central uiSNR at 7 T, but fail to do so at 10.5 T, suggesting that more coils and/or different type of coils will be needed at 10.5 T and higher magnetic fields.


Assuntos
Cabeça , Imageamento por Ressonância Magnética , Imagens de Fantasmas , Razão Sinal-Ruído , Humanos , Cabeça/diagnóstico por imagem , Imageamento por Ressonância Magnética/instrumentação , Encéfalo/diagnóstico por imagem , Desenho de Equipamento , Simulação por Computador , Processamento de Imagem Assistida por Computador/métodos
3.
Magn Reson Med ; 91(3): 1099-1114, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-37997011

RESUMO

PURPOSE: To evaluate the influence of skeletal maturation on sodium (23 Na) MRI relaxation parameters and the accuracy of tissue sodium concentration (TSC) quantification in human knee cartilage. METHODS: Twelve pediatric knee specimens were imaged with whole-body 10.5 T MRI using a density-adapted 3D radial projection sequence to evaluate 23 Na parameters: B1 + , T1 , biexponential T 2 * $$ {\mathrm{T}}_2^{\ast } $$ , and TSC. Water, collagen, and sulfated glycosaminoglycan (sGAG) content were calculated from osteochondral biopsies. The TSC was corrected for B1 + , relaxation, and water content. The literature-based TSC (TSCLB ) used previously published values for corrections, whereas the specimen-specific TSC (TSCSP ) used measurements from individual specimens. 23 Na parameters were evaluated in eight cartilage compartments segmented on proton images. Associations between 23 Na parameters, TSCLB - TSCSP difference, biochemical content, and age were determined. RESULTS: From birth to 12 years, cartilage water content decreased by 18%; collagen increased by 59%; and sGAG decreased by 36% (all R2 ≥ 0.557). The short T 2 * $$ {\mathrm{T}}_2^{\ast } $$ ( T 2 * S $$ {{\mathrm{T}}_2^{\ast}}_{\mathrm{S}} $$ ) decreased by 72%, and the signal fraction relaxing with T 2 * S $$ {{\mathrm{T}}_2^{\ast}}_{\mathrm{S}} $$ ( fT 2 * S $$ {{\mathrm{fT}}_2^{\ast}}_{\mathrm{S}} $$ ) increased by 55% during the first 5 years but remained relatively stable after that. TSCSP was significantly correlated with sGAG content from biopsies (R2 = 0.739). Depending on age, TSCLB showed higher or lower values than TSCSP . The TSCLB - TSCSP difference was significantly correlated with T 2 * S $$ {{\mathrm{T}}_2^{\ast}}_{\mathrm{S}} $$ (R2 = 0.850), fT 2 * S $$ {{\mathrm{fT}}_2^{\ast}}_{\mathrm{S}} $$ (R2 = 0.651), and water content (R2 = 0.738). CONCLUSION: TSC and relaxation parameters measured with 23 Na MRI provide noninvasive information about changes in sGAG content and collagen matrix during cartilage maturation. Cartilage TSC quantification assuming fixed relaxation may be feasible in children older than 5 years.


Assuntos
Cartilagem Articular , Cartilagem , Humanos , Criança , Pré-Escolar , Imageamento por Ressonância Magnética/métodos , Sódio , Colágeno , Água , Cartilagem Articular/diagnóstico por imagem
5.
IEEE Trans Biomed Circuits Syst ; 17(3): 610-620, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-37171925

RESUMO

Demonstrated is a standalone RF self-interference canceller for simultaneous transmit and receive (STAR) magnetic resonance imaging (MRI) at 1.5T. Standalone STAR cancels the leakage signal directly coupled between transmit and receive RF coils. A cancellation signal, introduced by tapping the input of a transmit coil with a power divider, is manipulated with voltage-controlled attenuators and phase shifters to match the leakage signal in amplitude, 180° out of phase, to exhibit high isolation between the transmitter and receiver. The cancellation signal is initially generated by a voltage-controlled oscillator (VCO); therefore, it does not require any external RF or synchronization signals from the MRI console for calibration. The system employs a field programmable gate array (FPGA) with an on-board analog to digital converter (ADC) to calibrate the cancellation signal by tapping the receive signal, which contains the leakage signal. Once calibrated, the VCO is disabled and the transmit signal path switches to the MRI console for STAR MR imaging. To compensate for the changes of parameters in RF sequences after the automatic calibration and to further improve isolation, a wireless user board that uses an ESP32 microcontroller was built to communicate with the FPGA for final fine-tuning of the output state. The standalone STAR system achieved 74.2 dB of isolation with a 94 second calibration time. With such high isolation, in-vivo MR images were obtained with approximately 40 mW of RF peak power.


Assuntos
Imageamento por Ressonância Magnética , Ondas de Rádio , Imagens de Fantasmas , Imageamento por Ressonância Magnética/métodos , Calibragem , Desenho de Equipamento
6.
IEEE Trans Med Imaging ; 42(9): 2643-2652, 2023 09.
Artigo em Inglês | MEDLINE | ID: mdl-37030782

RESUMO

For human brain magnetic resonance imaging (MRI), high channel count ( ≥ 32 ) radiofrequency receiver coil arrays are utilized to achieve maximum signal-to-noise ratio (SNR) and to accelerate parallel imaging techniques. With ultra-high field (UHF) MRI at 7 tesla (T) and higher, dipole antenna arrays have been shown to generate high SNR in the deep regions of the brain, however the array elements exhibit increased electromagnetic coupling with one another, making array construction more difficult with the increasing number of elements. Compared to a classical dipole antenna array, a sleeve antenna array incorporates the coaxial ground into the feed-point, resulting in a modified asymmetric antenna structure with improved intra-element decoupling. Here, we extended our previous 16-channel sleeve transceiver work and developed a 32-channel azimuthally arranged sleeve antenna receive-only array for 10.5 T human brain imaging. We experimentally compared the achievable SNR of the sleeve antenna array at 10.5 T to a more traditional 32-channel loop array bult onto a human head-shaped former. The results obtained with a head shaped phantom clearly demonstrated that peripheral intrinsic SNR can be significantly improved compared to a loop array with the same number of elements- except for the superior part of the phantom where sleeve antenna elements are not located.


Assuntos
Encéfalo , Imageamento por Ressonância Magnética , Humanos , Imageamento por Ressonância Magnética/métodos , Encéfalo/diagnóstico por imagem , Cabeça/diagnóstico por imagem , Ondas de Rádio , Imagens de Fantasmas , Razão Sinal-Ruído , Desenho de Equipamento
8.
Magn Reson Med ; 88(5): 2131-2138, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-35849739

RESUMO

PURPOSE: The SNR at the center of a spherical phantom of known electrical properties was measured in quasi-identical experimental conditions as a function of magnetic field strength between 3 T and 11.7 T. METHODS: The SNR was measured at the center of a spherical water saline phantom with a gradient-recalled echo sequence. Measurements were performed at NeuroSpin at 3, 7, and 11.7 T. The phantom was then shipped to Maastricht University and then to the University of Minnesota for additional data points at 7, 9.4, and 10.5 T. Experiments were carried out with the exact same type of birdcage volume coil (except at 3 T, where a similar coil was used) to attempt at isolating the evolution of SNR with field strength alone. Phantom electrical properties were characterized over the corresponding frequency range. RESULTS: Electrical properties were found to barely vary over the frequency range. Removing the influence of the flip-angle excitation inhomogeneity was crucial, as expected. After such correction, measurements revealed a gain of SNR growing as B0 1.94 ± 0.16 compared with B0 2.13 according to ultimate intrinsic SNR theory. CONCLUSIONS: By using quasi-identical experimental setups (RF volume coil, phantom, electrical properties, and protocol), this work reports experimental data between 3 T and 11.7 T, enabling the comparison with SNR theories in which conductivity and permittivity can be assumed to be constant with respect to field strength. According to ultimate SNR theory, these results can be reasonably extrapolated to the performance of receive arrays with greater than about 32 elements for central SNR in the same spherical phantom.


Assuntos
Imageamento por Ressonância Magnética , Ondas de Rádio , Humanos , Campos Magnéticos , Imageamento por Ressonância Magnética/métodos , Imagens de Fantasmas , Razão Sinal-Ruído
9.
Neuroimage ; 255: 119200, 2022 07 15.
Artigo em Inglês | MEDLINE | ID: mdl-35427769

RESUMO

Diffu0sion-weighted magnetic resonance imaging (dMRI) is a non-invasive imaging technique that provides information about the barriers to the diffusion of water molecules in tissue. In the brain, this information can be used in several important ways, including to examine tissue abnormalities associated with brain disorders and to infer anatomical connectivity and the organization of white matter bundles through the use of tractography algorithms. However, dMRI also presents certain challenges. For example, historically, the biological validation of tractography models has shown only moderate correlations with anatomical connectivity as determined through invasive tract-tracing studies. Some of the factors contributing to such issues are low spatial resolution, low signal-to-noise ratios, and long scan times required for high-quality data, along with modeling challenges like complex fiber crossing patterns. Leveraging the capabilities provided by an ultra-high field scanner combined with denoising, we have acquired whole-brain, 0.58 mm isotropic resolution dMRI with a 2D-single shot echo planar imaging sequence on a 10.5 Tesla scanner in anesthetized macaques. These data produced high-quality tractograms and maps of scalar diffusion metrics in white matter. This work demonstrates the feasibility and motivation for in-vivo dMRI studies seeking to benefit from ultra-high fields.


Assuntos
Imagem de Difusão por Ressonância Magnética , Macaca , Animais , Encéfalo/diagnóstico por imagem , Imagem de Difusão por Ressonância Magnética/métodos , Imagem Ecoplanar/métodos , Humanos , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética
10.
IEEE Antennas Wirel Propag Lett ; 21(9): 1857-1861, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37020750

RESUMO

In this letter, we evaluate antenna designs for ultra-high frequency and field (UHF) human brain magnetic resonance imaging (MRI) at 10.5 tesla (T). Although MRI at such UHF is expected to provide major signal-to-noise gains, the frequency of interest, 447 MHz, presents us with challenges regarding improved B1 + efficiency, image homogeneity, specific absorption rate (SAR), and antenna element decoupling for array configurations. To address these challenges, we propose the use of both monopole and dipole antennas in a novel hybrid configuration, which we refer to as a mono-dipole hybrid antenna (MDH) array. Compared to an 8-channel dipole antenna array of the same dimensions, the 8-channel MDH array showed an improvement in decoupling between adjacent array channels, as well as ~18% higher B1 + and SAR efficiency near the central region of the phantom based on simulation and experiment. However, the performances of the MDH and dipole antenna arrays were overall similar when evaluating a human model in terms of peak B1 + efficiency, 10 g SAR, and SAR efficiency. Finally, the concept of an MDH array showed an advantage in improved decoupling, SAR, and B1 + near the superior region of the brain for human brain imaging.

11.
Magn Reson Med ; 87(4): 2074-2088, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-34825735

RESUMO

PURPOSE: The purpose of this study is to introduce a new antenna element with improved transmit performance, named the nonuniform dielectric substrate (NODES) antenna, for building transmit arrays at ultrahigh-field. METHODS: We optimized a dipole antenna at 10.5 Tesla by maximizing the B1+ -SAR efficiency in a phantom for a human spine target. The optimization parameters included permittivity variation in the substrate, substrate thickness, antenna length, and conductor geometry. We conducted electromagnetic simulations as well as phantom experiments to compare the transmit/receive performance of the proposed NODES antenna design with existing coil elements from the literature. RESULTS: Single NODES element showed up to 18% and 30% higher B1+ -SAR efficiency than the fractionated dipole and loop elements, respectively. The new element is substantially shorter than a commonly used dipole, which enables z-stacked array formation; it is additionally capable of providing a relatively uniform current distribution along its conductors. The nine-channel transmit/receive NODES array achieved 7.5% higher B1+ homogeneity than a loop array with the same number of elements. Excitation with the NODES array resulted in 33% lower peak 10g-averaged SAR and required 34% lower input power than the loop array for the target anatomy of the spine. CONCLUSION: In this study, we introduced a new RF coil element: the NODES antenna. NODES antenna outperformed the widely used loop and dipole elements and may provide improved transmit/receive performance for future ultrahigh field MRI applications.


Assuntos
Imageamento por Ressonância Magnética , Ondas de Rádio , Desenho de Equipamento , Humanos , Imagens de Fantasmas , Coluna Vertebral/diagnóstico por imagem
12.
Sensors (Basel) ; 21(21)2021 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-34770558

RESUMO

For ultra-high field and frequency (UHF) magnetic resonance imaging (MRI), the associated short wavelengths in biological tissues leads to penetration and homogeneity issues at 10.5 tesla (T) and require antenna transmit arrays for efficiently generated 447 MHz B1+ fields (defined as the transmit radiofrequency (RF) magnetic field generated by RF coils). Previously, we evaluated a 16-channel combined loop + dipole antenna (LD) 10.5 T head array. While the LD array configuration did not achieve the desired B1+ efficiency, it showed an improvement of the specific absorption rate (SAR) efficiency compared to the separate 8-channel loop and separate 8-channel dipole antenna arrays at 10.5 T. Here we compare a 16-channel dipole antenna array with a 16-channel LD array of the same dimensions to evaluate B1+ efficiency, 10 g SAR, and SAR efficiency. The 16-channel dipole antenna array achieved a 24% increase in B1+ efficiency in the electromagnetic simulation and MR experiment compared to the LD array, as measured in the central region of a phantom. Based on the simulation results with a human model, we estimate that a 16-channel dipole antenna array for human brain imaging can increase B1+ efficiency by 15% with similar SAR efficiency compared to a 16-channel LD head array.


Assuntos
Imageamento por Ressonância Magnética , Ondas de Rádio , Encéfalo/diagnóstico por imagem , Desenho de Equipamento , Humanos , Imagens de Fantasmas
13.
Sci Rep ; 11(1): 23034, 2021 11 29.
Artigo em Inglês | MEDLINE | ID: mdl-34845314

RESUMO

In recent years, new human magnetic resonance imaging systems operating at static magnetic fields strengths of 7 Tesla or higher have become available, providing better signal sensitivity compared with lower field strengths. However, imaging human-sized objects at such high field strength and associated precession frequencies is limited due to the technical challenges associated with the wavelength effect, which substantially disturb the transmit field uniformity over the human body when conventional coils are used. Here we report a novel passive inductively-coupled radiofrequency resonator array design with a simple structure that works in conjunction with conventional coils and requires only to be tuned to the scanner's operating frequency. We show that inductive-coupling between the resonator array and the coil improves the transmit efficiency and signal sensitivity in the targeted region. The simple structure, flexibility, and cost-efficiency make the proposed array design an attractive approach for altering the transmit field distribution specially at high field systems, where the wavelength is comparable with the tissue size.


Assuntos
Encéfalo/diagnóstico por imagem , Imageamento por Ressonância Magnética/instrumentação , Imageamento por Ressonância Magnética/métodos , Ondas de Rádio , Adulto , Engenharia Biomédica , Simulação por Computador , Meios de Contraste , Eletricidade , Radiação Eletromagnética , Desenho de Equipamento , Feminino , Temperatura Alta , Humanos , Campos Magnéticos , Magnetismo , Masculino , Pessoa de Meia-Idade , Nanotecnologia , Imagens de Fantasmas , Processamento de Sinais Assistido por Computador
14.
Sensors (Basel) ; 21(18)2021 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-34577210

RESUMO

For human head magnetic resonance imaging at 10.5 tesla (T), we built an 8-channel transceiver dipole antenna array and evaluated the influence of coaxial feed cables. The influence of coaxial feed cables was evaluated in simulation and compared against a physically constructed array in terms of transmit magnetic field (B1+) and specific absorption rate (SAR) efficiency. A substantial drop (23.1% in simulation and 20.7% in experiment) in B1+ efficiency was observed with a tight coaxial feed cable setup. For the investigation of the feed location, the center-fed dipole antenna array was compared to two 8-channel end-fed arrays: monopole and sleeve antenna arrays. The simulation results with a phantom indicate that these arrays achieved ~24% higher SAR efficiency compared to the dipole antenna array. For a human head model, we observed 30.8% lower SAR efficiency with the 8-channel monopole antenna array compared to the phantom. Importantly, our simulation with the human model indicates that the sleeve antenna arrays can achieve 23.8% and 21% higher SAR efficiency compared to the dipole and monopole antenna arrays, respectively. Finally, we obtained high-resolution human cadaver images at 10.5 T with the 8-channel sleeve antenna array.


Assuntos
Cabeça , Imageamento por Ressonância Magnética , Simulação por Computador , Desenho de Equipamento , Cabeça/diagnóstico por imagem , Humanos , Imagens de Fantasmas
15.
Magn Reson Med ; 86(6): 3292-3303, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34272898

RESUMO

PURPOSE: Investigating the designs and effects of high dielectric constant (HDC) materials in the shape of a conformal helmet on the enhancement of RF field and reduction of specific absorption rate at 10.5 T for human brain studies. METHODS: A continuous and a segmented four-piece HDC helmet fit to a human head inside an eight-channel fractionated-dipole array were constructed and studied with a phantom and a human head model using computer electromagnetic simulations. The simulated transmit efficiency and receive sensitivity were experimentally validated using a phantom with identical electric properties and helmet-coil configurations of the computer model. The temporal and spatial distributions of displacement currents on the HDC helmets were analyzed. RESULTS: Using the continuous HDC helmet, simulation results in the human head model demonstrated an average transmit efficiency enhancement of 66%. A propagating displacement current was induced on the continuous helmet, leading to an inhomogeneous RF field enhancement in the brain. Using the segmented four-piece helmet design to reduce this effect, an average 55% and 57% enhancement in the transmit efficiency and SNR was achieved in human head, respectively, along with 8% and 28% reductions in average and maximum local specific absorption rate. CONCLUSION: The HDC helmets enhanced the transmit efficiency and SNR of the dipole array coil in the human head at 10.5 T. The segmentation of the helmet to disrupt the continuity of circumscribing displacement currents in the helmet produced a more uniform distribution of the transmit field and lower specific absorption rate in the human head compared with the continuous helmet design.


Assuntos
Dispositivos de Proteção da Cabeça , Imageamento por Ressonância Magnética , Encéfalo/diagnóstico por imagem , Desenho de Equipamento , Humanos , Imagens de Fantasmas , Ondas de Rádio
16.
Magn Reson Med ; 86(3): 1759-1772, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-33780032

RESUMO

PURPOSE: Receive array layout, noise mitigation, and B0 field strength are crucial contributors to SNR and parallel-imaging performance. Here, we investigate SNR and parallel-imaging gains at 10.5 T compared with 7 T using 32-channel receive arrays at both fields. METHODS: A self-decoupled 32-channel receive array for human brain imaging at 10.5 T (10.5T-32Rx), consisting of 31 loops and one cloverleaf element, was co-designed and built in tandem with a 16-channel dual-row loop transmitter. Novel receive array design and self-decoupling techniques were implemented. Parallel imaging performance, in terms of SNR and noise amplification (g-factor), of the 10.5T-32Rx was compared with the performance of an industry-standard 32-channel receiver at 7 T (7T-32Rx) through experimental phantom measurements. RESULTS: Compared with the 7T-32Rx, the 10.5T-32Rx provided 1.46 times the central SNR and 2.08 times the peripheral SNR. Minimum inverse g-factor value of the 10.5T-32Rx (min[1/g] = 0.56) was 51% higher than that of the 7T-32Rx (min[1/g] = 0.37) with R = 4 × 4 2D acceleration, resulting in significantly enhanced parallel-imaging performance at 10.5 T compared with 7 T. The g-factor values of 10.5 T-32 Rx were on par with those of a 64-channel receiver at 7 T (eg, 1.8 vs 1.9, respectively, with R = 4 × 4 axial acceleration). CONCLUSION: Experimental measurements demonstrated effective self-decoupling of the receive array as well as substantial gains in SNR and parallel-imaging performance at 10.5 T compared with 7 T.


Assuntos
Encéfalo , Imageamento por Ressonância Magnética , Aceleração , Encéfalo/diagnóstico por imagem , Desenho de Equipamento , Humanos , Imagens de Fantasmas , Razão Sinal-Ruído
17.
Magn Reson Med ; 85(6): 3522-3530, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33464649

RESUMO

PURPOSE: In this work, we investigated how the position of the radiofrequency (RF) shield can affect the signal-to-noise ratio (SNR) of a receive RF coil. Our aim was to obtain physical insight for the design of a 10.5T 32-channel head coil, subject to the constraints on the diameter of the RF shield imposed by the head gradient coil geometry. METHOD: We used full-wave numerical simulations to investigate how the SNR of an RF receive coil depends on the diameter of the RF shield at ultra-high magnetic field (UHF) strengths (≥7T). RESULTS: Our simulations showed that there is an SNR-optimal RF shield size at UHF strength, whereas at low field the SNR monotonically increases with the shield diameter. For a 32-channel head coil at 10.5T, an optimally sized RF shield could act as a cylindrical waveguide and increase the SNR in the brain by 27% compared to moving the shield as far as possible from the coil. Our results also showed that a separate transmit array between the RF shield and the receive array could considerably reduce SNR even if they are decoupled. CONCLUSION: At sufficiently high magnetic field strength, the design of local RF coils should be optimized together with the design of the RF shield to benefit from both near field and resonant modes.


Assuntos
Imageamento por Ressonância Magnética , Ondas de Rádio , Encéfalo/diagnóstico por imagem , Desenho de Equipamento , Cabeça , Imagens de Fantasmas , Razão Sinal-Ruído
18.
NMR Biomed ; 34(4): e4472, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33511726

RESUMO

A 32-channel RF coil was developed for brain imaging of anesthetized non-human primates (rhesus macaque) at 10.5 T. The coil is composed of an 8-channel dipole transmit/receive array, close-fitting 16-channel loop receive array headcap, and 8-channel loop receive array lower insert. The transceiver dipole array is composed of eight end-loaded dipole elements self-resonant at the 10.5 T proton Larmor frequency. These dipole elements were arranged on a plastic cylindrical former, which was split into two to allow for convenient animal positioning. Nested into the bottom of the dipole array former is located an 8-channel loop receive array, which contains 5 × 10 cm2 square loops arranged in two rows of four loops. Arranged in a close-fitting plastic headcap is located a high-density 16-channel loop receive array. This array is composed of 14 round loops 37 mm in diameter and 2 partially detachable, irregularly shaped loops that encircle the ears. Imaging experiments were performed on anesthetized non-human primates on a 10.5 T MRI system equipped with body gradients with a 60 cm open bore. The coil enabled submillimeter (0.58 mm isotropic) high-resolution anatomical and functional imaging as well as tractography of fasciculated axonal bundles. The combination of a close-fitting loop receive array and dipole transceiver array allowed for a higher-channel-count receiver and consequent higher signal-to-noise ratio and parallel imaging gains. Parallel imaging performance supports high-resolution functional MRI and diffusion MRI with a factor of three reduction in sampling. The transceive array elements during reception contributed approximately one-quarter of the signal-to-noise ratio in the lower half of the brain, which was farthest from the close-fitting headcap receive array.


Assuntos
Cabeça/diagnóstico por imagem , Imageamento por Ressonância Magnética/métodos , Animais , Feminino , Macaca mulatta , Razão Sinal-Ruído
19.
IEEE Trans Biomed Eng ; 68(8): 2563-2573, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-33513097

RESUMO

OBJECTIVE: In dental MRI, intraoral coils provide higher signal-to-noise ratio (SNR) than coils placed outside the mouth. This study aims to design an intraoral dipole antenna and demonstrates the feasibility of combining it with an extraoral coil. METHODS: Dipole antenna design was chosen over loop design, as it is open toward the distal; therefore, it does not restrain tongue movement. The dipole design offers also an increased depth-of-sensitivity that allows for MRI of dental roots. Different dipole antenna designs were simulated using a finite-difference-time-domain approach. Ribbon, wire, and multi-wire arms were compared. The best design was improved further by covering the ends of the dipole arms with a high-permittivity material. Phantom and in vivo measurements were conducted on a 3T clinical MRI system. RESULTS: The best transmit efficiency and homogeneity was achieved with a multi-wire curved dipole antenna with 7 wires for each arm. With an additional high-permittivity cap the transmit field inhomogeneity was further reduced from 20% to 5% along the dipole arm. When combined with extraoral flexible surface-coil, the coupling between the coils was less than -32dB and SNR was increased. CONCLUSION: Using intraoral dipole design instead of loop improves patient comfort. We demonstrated feasibility of the intraoral dipole combined with an extraoral flexible coil-array for dental MRI. Dipole antenna enabled decreasing imaging field-of-view, and reduced the prevalent signal from tongue. SIGNIFICANCE: This study highlights the advantages and the main challenges of the intraoral RF coils and describes a novel RF coil that addresses those challenges.


Assuntos
Imageamento por Ressonância Magnética , Ondas de Rádio , Desenho de Equipamento , Humanos , Imagens de Fantasmas , Razão Sinal-Ruído
20.
IEEE Trans Med Imaging ; 40(4): 1147-1156, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33360987

RESUMO

Multi-element transmit arrays with low peak 10 g specific absorption rate (SAR) and high SAR efficiency (defined as ( [Formula: see text]SAR [Formula: see text] are essential for ultra-high field (UHF) magnetic resonance imaging (MRI) applications. Recently, the adaptation of dipole antennas used as MRI coil elements in multi-channel arrays has provided the community with a technological solution capable of producing uniform images and low SAR efficiency at these high field strengths. However, human head-sized arrays consisting of dipole elements have a practical limitation to the number of channels that can be used due to radiofrequency (RF) coupling between the antenna elements, as well as, the coaxial cables necessary to connect them. Here we suggest an asymmetric sleeve antenna as an alternative to the dipole antenna. When used in an array as MRI coil elements, the asymmetric sleeve antenna can generate reduced peak 10 g SAR and improved SAR efficiency. To demonstrate the advantages of an array consisting of our suggested design, we compared various performance metrics produced by 16-channel arrays of asymmetric sleeve antennas and dipole antennas with the same dimensions. Comparison data were produced on a phantom in electromagnetic (EM) simulations and verified with experiments at 10.5 Tesla (T). The results produced by the 16-channel asymmetric sleeve antenna array demonstrated 28 % lower peak 10 g SAR and 18.6 % higher SAR efficiency when compared to the 16-channel dipole antenna array.


Assuntos
Imageamento por Ressonância Magnética , Ondas de Rádio , Benchmarking , Desenho de Equipamento , Humanos , Imagens de Fantasmas
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