Assuntos
Dor Abdominal/etiologia , Neoplasias das Glândulas Suprarrenais/diagnóstico , Hipertensão/etiologia , Feocromocitoma/diagnóstico , Neoplasias das Glândulas Suprarrenais/complicações , Neoplasias das Glândulas Suprarrenais/urina , Adrenalectomia , Adulto , Neoplasias Ósseas/secundário , Carcinoma/diagnóstico , Diagnóstico Diferencial , Emergências , Evolução Fatal , Genes Neoplásicos , Cefaleia/etiologia , Humanos , Hiperglicemia/etiologia , Neoplasias Hepáticas/secundário , Neoplasias Hepáticas/cirurgia , Neoplasias Pulmonares/secundário , Metástase Linfática , Masculino , Mediastino , Metanefrina/urina , Nefrectomia , Normetanefrina/urina , Feocromocitoma/complicações , Feocromocitoma/secundário , Feocromocitoma/urinaAssuntos
Neoplasias das Glândulas Suprarrenais/diagnóstico , Hemorragia , Hipertensão/etiologia , Infarto do Miocárdio/etiologia , Feocromocitoma/diagnóstico , Neoplasias das Glândulas Suprarrenais/complicações , Neoplasias das Glândulas Suprarrenais/cirurgia , Adrenalectomia/métodos , Catecolaminas/fisiologia , Humanos , Laparoscopia , Masculino , Metanefrina/urina , Pessoa de Meia-Idade , Feocromocitoma/complicações , Feocromocitoma/cirurgiaAssuntos
Carcinoma Papilar/secundário , Neoplasias Pulmonares/secundário , Neoplasias da Glândula Tireoide/diagnóstico , Antineoplásicos/uso terapêutico , Benzenossulfonatos/uso terapêutico , Biópsia por Agulha , Carcinoma de Células Grandes/diagnóstico , Carcinoma Papilar/diagnóstico , Carcinoma Papilar/diagnóstico por imagem , Carcinoma Papilar/tratamento farmacológico , Carcinoma Papilar/cirurgia , Terapia Combinada , Diagnóstico Tardio , Diagnóstico Diferencial , Erros de Diagnóstico , Humanos , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/cirurgia , Excisão de Linfonodo , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Imagem Multimodal , Niacinamida/análogos & derivados , Cuidados Paliativos , Compostos de Fenilureia , Tomografia por Emissão de Pósitrons , Piridinas/uso terapêutico , Sorafenibe , Neoplasias da Glândula Tireoide/patologia , Neoplasias da Glândula Tireoide/cirurgia , Tireoidectomia , Tomografia Computadorizada por Raios X , Tuberculose Miliar/diagnósticoRESUMO
BACKGROUND AND OBJECTIVES: Our aim was to evaluate the prevalence of parietal cell antibodies (PCA) in patients with autoimmune thyroid disease (ATD). MATERIAL AND METHODS: We performed a descriptive, cross-sectional study of patients with ATD. The presence of PCA was determined. Elevated antithyroid antibodies (ATAs) were defined as those higher than the 75th percentile of distribution. Multivariate logistic regression models were built to assess the independent contribution of the following variables to PCA positivity: age, sex, hemoglobin, medium corpuscular volume (MCV), dose/Kg of levothyroxine (LT4), disease duration and elevated ATA levels. RESULTS: A total of 148 patients were included (137 females). The mean age was 45.7 (SD 15) years and disease duration was 4.5 (SD 4) years. Forty-three patients (29%) with Graves' disease and 105 (71%) with primary hypothyroidism were included. The 75th percentile of distribution was 420U/ml for anti-peroxidase antibodies and 200U/ml for anti-thyroglobulin antibodies. PCA positivity was found in 30 patients, with an overall prevalence of 20.3%. PCA positivity with titers higher than 1/640 was found in 19 patients (12.8%). The only independent predictive factor of PCA positivity was the presence of elevated levels of ATAs (odds ratio (OR)=3; 95% confidence interval (CI): 1.1-8.6; p=0.04). The only independent predictive factor of PCA positivity at titers >/=1/640 was also the presence of elevated levels of ATAS (OR=7.3; 95% CI: 1.6-32.7; p=0.009). CONCLUSIONS: The prevalence of PCA positivity in patients with ATD was 20%. Elevated levels of ATAs increase the risk of PCA positivity.