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1.
Vaccine ; 38(43): 6849-6857, 2020 10 07.
Artigo em Inglês | MEDLINE | ID: mdl-32553492

RESUMO

OBJECTIVE: Intussusception has been linked with rotavirus vaccine (RVV) as a rare adverse reaction. In view of limited background data on intussusception in India and in preparation for RVV introduction, a surveillance network was established to document the epidemiology of intussusception cases in Indian children. METHODS: Intussusception in children 2-23 months were documented at 19 nationally representative sentinel hospitals through a retrospective surveillance for 69 months (July 2010 to March 2016). For each case clinical, hospital course, treatment and outcome data were collected. RESULTS: Among the 1588 intussusception cases, 54.5% were from South India and 66.3% were boys. The median age was 8 months (IQR 6, 12) with 34.6% aged 2-6 months. Seasonal variation with higher cases were documented during March-June period. The most common symptoms and signs were vomiting (63.4%), bloody stool (49.1%), abdominal pain (46.9%) and excessive crying (42.8%). The classical triad (vomiting, abdominal pain, and blood in stools) was observed in 25.6% cases. 96.4% cases were diagnosed by ultrasound with ileocolic location as the commonest (85.3%). Management was done by reduction (50.8%) and surgery (41.1%) and only 1% of the patients' died. 91.1% cases met Brighton criteria level 1 and 3.3% Level 2. Between 2010 and 2015, the case load and case ratio increased across all regions. CONCLUSION: Intussusception cases have occurred in children across all parts of the country, with low case fatality in the settings studied. The progressive rise cases could indicate an increasing awareness and availability of diagnostic facilities.


Assuntos
Intussuscepção , Vacinas contra Rotavirus , Criança , Pré-Escolar , Humanos , Índia/epidemiologia , Lactente , Intussuscepção/epidemiologia , Masculino , Estudos Retrospectivos , Vacinas contra Rotavirus/efeitos adversos , Centros de Atenção Terciária
2.
Paediatr Int Child Health ; 39(2): 139-141, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-29493439

RESUMO

Tuberculous adenitis presenting as an isolated cold abscess in the parapharyngeal space is very uncommon and has not been reported in the paediatric age group; presentation as a retropharyngeal abscess, however, is well known. Nine-year-old boy with a progressively increasing swelling on the right side of the neck for 2 months was referred with a clinical diagnosis of neuroblastoma. Surgical exploration of the parapharyngeal space by needle aspiration yielded a cheesy material and Mycobacterium tuberculosis was detected by DNA TB PCR. Tuberculosis should always be considered in the differential diagnosis of a cervical swelling in a child.


Assuntos
Abscesso/etiologia , Abscesso/patologia , Mycobacterium tuberculosis/isolamento & purificação , Espaço Parafaríngeo/patologia , Tuberculose dos Linfonodos/complicações , Tuberculose dos Linfonodos/diagnóstico , Biópsia por Agulha Fina , Criança , DNA Bacteriano/genética , DNA Bacteriano/isolamento & purificação , Humanos , Masculino , Mycobacterium tuberculosis/genética , Pescoço/diagnóstico por imagem , Reação em Cadeia da Polimerase , Tomografia Computadorizada por Raios X , Tuberculose dos Linfonodos/patologia
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