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1.
J Prosthet Dent ; 2022 Aug 11.
Artigo em Inglês | MEDLINE | ID: mdl-35965133

RESUMO

Integration between the phases of computer-based guided dental implant surgery can be used to optimize oral rehabilitation. Two new surgical guides prepared by using the 3D metal and polymer printing technology are presented for immediate implant loading and definitive fixed prosthesis construction in flapless dental implant surgery. Nine implants and 2 fixed prostheses were installed in 2 completely edentulous adult patients by using a metallopolymer surgical guide with a metal central bar attached to a polymer seal or a metal guide. Virtual planning was used to design the 3D-printed surgical guides, which were then constructed by using selective laser sintering (SLM) and selective laser melting (SLS). The 3D-printed surgical guides oriented the surgical placement of the implants and were welded to the abutments and attached to the denture framework. The technique allowed implants and prostheses to be installed on the same day.

2.
J Prosthet Dent ; 116(6): 874-879, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27460326

RESUMO

STATEMENT OF PROBLEM: Extensive occlusal adjustments and misfit of the prosthesis to prosthetic components are frequent problems related to fixed interim prosthesis fabrication with immediate dental implant loading. PURPOSE: The purpose of this clinical trial was to evaluate a prosthetic guide made with a rapid prototype model based on virtual surgical planning. This prosthetic guide was used to fabricate fixed interim prostheses that would allow immediate implant loading after computer-guided implant installation. MATERIAL AND METHODS: Nine interim prostheses were made for 9 participants with complete maxillary or mandibular edentulism. The virtual prosthetic guide was planned using computer-assisted design (CAD) software and was fabricated with rapid prototyping equipment (selective laser sintering). The prosthetic guide had 3 portions: the occlusal portion, which had occlusal registration; the connection portion, which had the information of the position and angulation of the abutment/implant projection; and the mucosa portion, which had the registration of the alveolar mucosa architecture. The prosthetic guide was used by a dental technician to fabricate prostheses. A single trained examiner evaluated the passive fit of the interim prostheses, the average time required for installing the interim prosthesis and for occlusal adjustments, the satisfaction of the patient with the prosthesis; and the screws, torque, occlusion, and prosthesis status. RESULTS: Passive fit was achieved between the prosthetic components and prostheses in 7 participants. The average time required for installing the fixed interim prostheses was 64.44 minutes. All participants reported being more pleased with the fixed interim prosthesis than with the prosthesis worn before implant placement. Prosthesis fractures were observed in 3 participants (2 in the maxilla and 1 in the mandible); all fractures occurred 3 months or more after delivery. No further complication was observed during 6 months of follow-up. CONCLUSIONS: The prosthetic guide enabled fabrication of interim immediate prostheses that were easily seated and adjusted to accommodate any shifts in implant position occurring during computer-guided surgery. Immediate implant loading could be achieved in a reasonable operative time.


Assuntos
Planejamento de Prótese Dentária , Carga Imediata em Implante Dentário/instrumentação , Adulto , Idoso , Feminino , Humanos , Carga Imediata em Implante Dentário/métodos , Masculino , Mandíbula/cirurgia , Maxila/cirurgia , Pessoa de Meia-Idade
3.
Biomed Res Int ; 2013: 835385, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24199200

RESUMO

PURPOSE: To assess glutamine/glutamate (Glx) and lactate (Lac) metabolism using proton magnetic resonance spectroscopic imaging (1H-MRS) in order to differentiate between adrenal gland nodules and masses (adenomas, pheochromocytomas, carcinomas, and metastases). MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained. A total of 130 patients (47 men) with 132 adrenal nodules/masses were prospectively assessed (54 ± 14.8 years). A multivoxel system was used with a two-dimensional point-resolved spectroscopy/chemical-shift imaging sequence. Spectroscopic data were interpreted by visual inspection and peak amplitudes of lipids (Lip), choline (Cho), creatine (Cr), Lac, and Glx. Lac/Cr and Glx/Cr were calculated. Glx/Cr was assessed in relation to lesion size. RESULTS: Statistically significant differences were observed in Glx/Cr results between adenomas and pheochromocytomas (P < 0.05), however, with a low positive predictive value (PPV). Glx levels were directly proportional to lesion size in carcinomas. A cutoff point of 1.44 was established for the differentiation between carcinomas larger versus smaller than 4 cm, with 75% sensitivity, 100% specificity, 100% PPV, and 80% accuracy. Lac/Cr results showed no differences across lesions. A cutoff point of -6.5 for Lac/Cr was established for carcinoma diagnosis. CONCLUSION: Glx levels are directly proportional to lesion size in carcinomas. A cutoff point of -6.5 Lac/Cr differentiates carcinomas from noncarcinomas.


Assuntos
Neoplasias das Glândulas Suprarrenais , Glândulas Suprarrenais , Ácido Glutâmico/metabolismo , Glutamina/metabolismo , Espectroscopia de Ressonância Magnética , Adolescente , Neoplasias das Glândulas Suprarrenais/diagnóstico por imagem , Neoplasias das Glândulas Suprarrenais/metabolismo , Glândulas Suprarrenais/diagnóstico por imagem , Glândulas Suprarrenais/metabolismo , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia
4.
Nutrition ; 29(2): 393-8, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23141118

RESUMO

OBJECTIVES: To evaluate the association between visceral fat and cardiovascular risk factors and to compare the ultrasonographic measurements of abdominal visceral fat with abdominal circumference (AC). METHODS: This observational cross-sectional study categorized pubertal and postpubertal adolescents into a control group (n = 49) and an obese group (n = 46). Weight, height, AC, blood pressure, biochemical tests (lipid profile, triacylglycerols, fasting glucose for insulinemia, and serum uric acid), and ultrasound to measure visceral fat were assessed. RESULTS: We found significant differences in the vascular risk variables between the groups, except for total cholesterol and fasting blood glucose level. We also observed that 31 subjects in the control group presented abnormalities in cardiovascular risk factors. The correlations between abdominal visceral fat (measured by ultrasound or the AC) and cardiovascular risk factors were significant. In the entire sample, AC presented better sensitivity and specificity than the ultrasound-measured abdominal visceral fat for identifying the presence of a cluster of at least three cardiovascular risk factors (areas under the receiver operating characteristics curve 0.87 and 0.73, respectively). CONCLUSION: Ultrasonographic measurements of visceral fat were correlated with cardiovascular risk factors, but this association was also demonstrable with AC measurements. Our results suggest that the measurement of visceral fat by ultrasound is unnecessary for the diagnosis of cardiovascular risk in well-nourished or obese adolescents.


Assuntos
Doenças Cardiovasculares/diagnóstico por imagem , Doenças Cardiovasculares/fisiopatologia , Gordura Intra-Abdominal/diagnóstico por imagem , Circunferência da Cintura , Adolescente , Glicemia/análise , Doenças Cardiovasculares/complicações , Colesterol/sangue , Estudos Transversais , Feminino , Humanos , Insulina/sangue , Masculino , Obesidade/sangue , Obesidade/fisiopatologia , Fatores de Risco , Triglicerídeos/sangue , Ultrassonografia , Adulto Jovem
5.
J Matern Fetal Neonatal Med ; 24(11): 1384-91, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21401311

RESUMO

OBJECTIVES: The aim of this study was to evaluate feasibility of fetal lateral ventricle (LV) volumetry in fetuses with ventriculomegaly and to compare measurements performed by 3D sonographic method virtual organ computer-aided analysis (VOCAL) with those obtained by magnetic resonance imaging (MRI). METHODS: This cross-sectional study evaluated 30 fetuses with atrial width (AW) between 10 and 30 mm, from 20 to 36 gestational weeks. Fifty-nine ventricles were measured by two observers. Sonographic volumetric measurements using VOCAL 30° were performed with an ACCUVIX XQ machine (Medison, Korea) and MRI assessments with a Sonata system using ARGUS software (Siemens, Germany). Agreement between both techniques was assessed by intraclass correlation coefficient (ICC) calculation, and proportionate Bland-Altman plots were constructed. RESULTS: A high degree of reliability was observed between VOCAL and MRI measurements (ICC 0.928, 95%CI [0.876;0.958]). Bland-Altman plots confirmed the high correlation (mean of differences: 1.62 cm(3) and standard deviation: ± 8.41 cm(3)). CONCLUSION: Three-dimensional volumetry of fetal LVs by VOCAL method has good agreement with fetal MRI in fetuses with ventriculomegaly and may be used as an additional tool in patient counseling and prognosis prediction.


Assuntos
Ventrículos Cerebrais/embriologia , Hidrocefalia/embriologia , Imageamento por Ressonância Magnética , Ultrassonografia Pré-Natal , Adolescente , Adulto , Ventrículos Cerebrais/diagnóstico por imagem , Estudos Transversais , Feminino , Humanos , Hidrocefalia/diagnóstico por imagem , Hidrocefalia/patologia , Masculino , Gravidez , Prognóstico , Ultrassonografia Pré-Natal/métodos
6.
Nephron Clin Pract ; 115(3): c189-94, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20413996

RESUMO

BACKGROUND: Mortality due to cardiovascular causes is high in chronic kidney disease (CKD). Intima-media thickness (IMT) and inflammation are early atherosclerosis markers, although data are lacking about their association in the CKD non-dialysis-dependent (CKD-NDD) population. The aim of the present study was to evaluate the association between IMT, inflammation and other cardiovascular risk factors in such patients. METHODS: CKD-NDD patients (n = 122) were subjected to measurements of carotid IMT and inflammatory marker levels in a cross-sectional study. RESULTS: Mean patient age was 55.2 +/- 11.3 years (61.5% males). Median C-reactive protein (CRP) was 0.28 mg/dl (0.03-14.2). The median interleukin (IL)-6 count was 4.75 pg/ml (0.7-243), the mean adiponectin was 27.8 +/- 7.3 ng/ml and the mean IMT was 0.61 +/- 0.19 mm. Four (3.3%) patients had IMT above the normal range. IMT was higher in males (p < 0.001), patients with estimated glomerular filtration rate <60 ml/min (p = 0.030), inflammation (p = 0.005) and higher IL-6 levels (p = 0.023). IMT was correlated with age (R = 0.538; p < 0.001), waist circumference (R = 0.235; p = 0.016), CRP (R = 0.191; p = 0.035) and systolic blood pressure (R = 0.181; p = 0.048). In a multiple regression analysis, the independent determinants of IMT were age (beta = 0.512; p < 0.001) and CRP levels (beta = 0.159; p = 0.041). CONCLUSION: The present study demonstrated that although the IMT values were within the normal range, there was a clear association of IMT with age, as well as with inflammation in an asymptomatic CKD-NDD population.


Assuntos
Doenças Cardiovasculares/patologia , Falência Renal Crônica/patologia , Diálise Renal , Túnica Íntima/patologia , Túnica Média/patologia , Adulto , Idoso , Doenças Cardiovasculares/etiologia , Estudos Transversais , Feminino , Humanos , Inflamação/etiologia , Inflamação/patologia , Inflamação/fisiopatologia , Falência Renal Crônica/complicações , Falência Renal Crônica/fisiopatologia , Masculino , Pessoa de Meia-Idade , Fatores de Risco
7.
Clin J Am Soc Nephrol ; 4(4): 838-44, 2009 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-19339428

RESUMO

BACKGROUND AND OBJECTIVES: Nephrolithiasis (LIT) is more prevalent in patients with autosomal dominant polycystic kidney disease (ADPKD) than in the general population. Renal ultrasonography may underdetect renal stones because of difficulties imposed by parenchymal and/or cyst wall calcifications. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A total of 125 patients with ADPKD underwent ultrasonography and unenhanced computed tomography (CT) scan, routine blood chemistry, and spot and 24-h urine collections. RESULTS: CT scan detected calculi in 32 patients, including 20 whose previous ultrasonography revealed no calculi. The percentage of hypocitraturia was high but not statistically different between patients with ADPKD+LIT or ADPKD. Hyperuricosuria and distal renal tubular acidosis were less prevalent but also did not differ between groups, whereas hyperoxaluria was significantly higher in the former. Hypercalciuria was not detected. Renal volume was significantly higher in patients with ADPKD+LIT versus ADPKD, and a stepwise multivariate logistic regression analysis showed that a renal volume >or=500 ml was a significant predictor of LIT in patients with ADPKD and normal renal function, after adjustments for age and hypertension. CONCLUSIONS: CT scan was better than ultrasonography to detect LIT in patients with ADPKD. Larger kidneys from patients with ADPKD were more prone to develop stones, irrespective of the presence of metabolic disturbances.


Assuntos
Rim/patologia , Nefrolitíase/diagnóstico , Rim Policístico Autossômico Dominante/complicações , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/sangue , Biomarcadores/urina , Análise Química do Sangue , Feminino , Humanos , Rim/diagnóstico por imagem , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Nefrolitíase/sangue , Nefrolitíase/etiologia , Nefrolitíase/patologia , Nefrolitíase/urina , Tamanho do Órgão , Rim Policístico Autossômico Dominante/sangue , Rim Policístico Autossômico Dominante/patologia , Rim Policístico Autossômico Dominante/urina , Valor Preditivo dos Testes , Medição de Risco , Fatores de Risco , Tomografia Computadorizada Espiral , Ultrassonografia , Urinálise , Adulto Jovem
8.
Mol Med ; 14(7-8): 429-35, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18475311

RESUMO

The aim of this study was to investigate the association between urinary 90 kDa N-domain Angiotensin I-converting enzyme (ACE) form with C-reactive protein (CRP) and homocysteine plasma levels (Hcy), urinary nitric oxide (NOu), and endothelial function (EF) in normotensive subjects. Forty healthy subjects were evaluated through brachial Doppler US to test the response to reactive hyperemia and a panel of blood tests to determine CRP and Hcy levels, NOu, and urinary ACE. They were divided into groups according to the presence (ACE90+) or absence (ACE90-) of the 90 kDa ACE, the presence (FH+) or absence (FH-) of family history of hypertension, and the presence or absence of these two variables FH+/ACE90+ and FH-/ACE90-. We found an impaired endothelial dilatation in subjects who presented the 90 kDa N-domain ACE as follows: 11.4% +/- 5.3% in ACE90+ compared with 17.6% +/- 7.1% in ACE90- group and 12.4% +/- 5.6% in FH+/ACE90+ compared with 17.7% +/- 6.2% in FH-/ACE90- group, P < 0.05. Hcy and CRP levels were statistically significantly lower in FH+/ACE90+ than in FH-/ACE90- group, as follows: 10.0 +/- 2.3 microM compared with 12.7 +/- 1.5 microM, and 1.3 +/- 1.8 mg/L compared with 3.6 +/- 2.0 mg/L, respectively. A correlation between flow-mediated dilatation (FMD) and CRP, Hcy, and NOu levels was not found. Our study suggests a reduction in the basal NO production confirmed by NOu analysis in subjects with the 90 kDa N-domain ACE isoform alone or associated with a family history of hypertension. Our data suggest that the presence of the 90 kDa N-domain ACE itself may have a negative impact on flow-mediated dilatation stimulated by reactive hyperemia.


Assuntos
Biomarcadores/sangue , Endotélio Vascular/fisiologia , Inflamação/sangue , Peptidil Dipeptidase A/urina , Adolescente , Adulto , Aterosclerose/sangue , Aterosclerose/fisiopatologia , Aterosclerose/urina , Proteína C-Reativa/análise , Estudos Transversais , Saúde da Família , Homocisteína/sangue , Humanos , Hipertensão/sangue , Hipertensão/fisiopatologia , Hipertensão/urina , Inflamação/fisiopatologia , Masculino , Estrutura Terciária de Proteína , Vasodilatação/fisiologia
9.
Nephrol Dial Transplant ; 22(12): 3527-32, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-17704115

RESUMO

BACKGROUND: Cardiovascular mortality is high among patients with chronic kidney disease. Pulse wave velocity (PWV) is a simple method used for arterial distensibility evaluation. Few data are available concerning PWV in pre-dialysis patients. The aim of this study was to evaluate the association between PWV and cardiovascular disease in pre-dialysis. METHODS: One hundred and four patients were submitted to PWV analysis, coronary artery calcium (CAC) determination with a multi-slice CT scan of the coronary arteries, echocardiogram and a carotid intima-media thickness (IMT) evaluation, with a high resolution ultrasound. The demographic characteristics and laboratory tests results were studied. RESULTS: The mean age of those studied was 54.4 +/- 11.5 years, 60% were males and the mean creatinine clearance was 40 ml/min/1.73 m(2). The mean PWV was 12.2 +/- 3.4 m/s and it was significantly higher in males, diabetics, those with creatinine clearance <60 ml/min and proteinuria > or =1 g/24 h. PWV was correlated with systolic blood pressure, age, triglycerides, total cholesterol and 24 h proteinuria. In the multiple regression analysis, PWV was significantly associated with diabetes, age, systolic blood pressure and cholesterol. Fifty-eight patients (56%) presented coronary calcification and PWV correlated with coronary calcium score (R = 0.48; P < 0.001) and calcium volume (R = 0.50; P < 0.001). Moreover, PWV was higher in patients with coronary calcification (13.4 +/- 3.6 m/s vs 10.7 +/- 2.4 m/s; P < 0.001). The mean left ventricular mass index (LVMI) was 106 +/- 31 g/m(2) and 24% of patients had left ventricular hypertrophy, while 19 (18.3%) patients had left ventricular dysfunction. PVW was correlated with LVMI (R = 0.25; P = 0.01) while no association could be seen between PWV and the ejection fraction or left ventricular dysfunction. A correlation between the IMT and PWV was observed (R = 0.27; P = 0.005). In addition, those with a thicker IMT had a higher PWV (13.2 +/- 3.4 m/s vs 11. 2 +/- 3.2 m/s; P = 0.003). CONCLUSION: PWV is associated with cardiovascular disease in pre-dialysis patients and can be a useful tool to identify patients with increased cardiovascular risk.


Assuntos
Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/etiologia , Nefropatias/complicações , Velocidade do Fluxo Sanguíneo , Pressão Sanguínea , Doenças Cardiovasculares/fisiopatologia , Doença Crônica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Vigilância da População , Pulso Arterial , Diálise Renal
10.
Hypertension ; 48(1): 45-50, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16682609

RESUMO

Low birth weight has been associated with an increased incidence of adult cardiovascular disease. Endothelial dysfunction and high levels of serum uric acid are associated with hypertension. In this study, we have determined whether uric acid is related to blood pressure and vascular function in children with low birth weight. We evaluated vascular function using high-resolution ultrasound, blood pressure, and uric acid levels in 78 children (35 girls, 43 boys, aged 8 to 13 years). Increasing levels of uric acid and systolic blood pressure were observed in children with low birth weight. Birth weight was inversely associated with both systolic blood pressure and uric acid; on the other hand, uric acid levels were directly correlated with systolic blood pressure in children of the entire cohort. Low birth weight was associated with reduced flow-mediated dilation (r=0.427, P<0.001). Because the children with low birth weight had elevated uric acid as well as higher systolic blood pressure levels, we evaluated the correlation between these variables. In the low birth weight group, multiple regression analysis revealed that uric acid (beta=-2.886; SE=1.393; P=0.040) had a graded inverse relationship with flow-mediated dilation, which was not affected in a model adjusting for race and gender. We conclude that children with a history of low birth weight show impaired endothelial function and increased blood pressure and uric acid levels. These findings may be early expressions of vascular compromise, contributing to susceptibility to disease in adult life.


Assuntos
Endotélio Vascular/fisiologia , Hipertensão/etiologia , Recém-Nascido de Baixo Peso/fisiologia , Ácido Úrico/sangue , Adolescente , Pressão Sanguínea , Tamanho Corporal , Artéria Braquial/diagnóstico por imagem , Artéria Braquial/fisiologia , Criança , Endotélio Vascular/diagnóstico por imagem , Feminino , Seguimentos , Humanos , Hipertensão/diagnóstico , Recém-Nascido , Modelos Lineares , Lipídeos/sangue , Masculino , Fatores de Risco , Ultrassonografia , Vasodilatação
11.
J Pediatr (Rio J) ; 81(5): 395-9, 2005.
Artigo em Português | MEDLINE | ID: mdl-16247542

RESUMO

OBJECTIVE: To define standards for normal endothelial function in adolescents by high-resolution ultrasound measurement of endothelium-dependent vascular dilatation. METHODS: This was a cross-sectional, descriptive, observational study and part of the thematic project "Clinical Study of Growth, Behavior, Arterial Hypertension, Obesity and Oral Health" (ECCCHOS) that was developed by the Discipline of Nutrition at the Universidade Federal de São Paulo. Thirty-one adolescents, eight male and twenty-three female, with no risk factors for systemic arterial hypertension were selected from 1,420 secondary school students. The students were daytime pupils at a school in the southeastern district of the city of São Paulo, the capital of São Paulo state, located in the Southeast region of Brazil. All results are presented in the form of means with standard deviations and percentiles. RESULTS: For male students, endothelium-dependant dilation 90 seconds after the cuff was released was 20.9+/-6.7% [mean +/-1 standard deviation] with a 10th percentile of 12.5 and for females these figures were 18.8+/-12.9% with a 10th percentile of 6.6%. Values for the whole group of subjects were 19.3+/-11.7% and 6.7%, respectively. CONCLUSION: Endothelium-dependant vascular dilation of 6.7%, after 90 seconds, which corresponds to the 10th percentile, can be considered the lower limit of normality for this age group. Knowledge of this limit is important for the diagnosis of endothelium dysfunction that appears before cardiovascular disease.


Assuntos
Endotélio Vascular/fisiologia , Hipertensão/fisiopatologia , Vasodilatação/fisiologia , Adolescente , Peso ao Nascer/fisiologia , Pressão Sanguínea/fisiologia , Índice de Massa Corporal , Estudos Transversais , Endotélio Vascular/diagnóstico por imagem , Feminino , Humanos , Hipertensão/diagnóstico por imagem , Masculino , Fatores de Risco , Ultrassonografia
12.
J. pediatr. (Rio J.) ; 81(5): 395-399, set.-out. 2005. tab
Artigo em Português | LILACS | ID: lil-418524

RESUMO

OBJETIVO: Definir padrões de normalidade da função endotelial de adolescentes através de avaliação ultra-sonográfica da dilatação vascular dependente do endotélio. MÉTODOS: Estudo descritivo observacional de corte transversal, parte do projeto temático "Estudos Clínicos de Crescimento, Comportamento, Hipertensão Arterial, Obesidade e Saúde Bucal", de sigla ECCCHOS, desenvolvido na Disciplina de Nutrologia da Universidade Federal de São Paulo - Escola Paulista de Medicina. Foram selecionados 31 adolescentes, sendo oito do sexo masculino e 23 do feminino, sem fatores de risco conhecidos para hipertensão arterial sistêmica, entre 1.420 alunos de uma escola de ensino médio da cidade de São Paulo, capital do estado de São Paulo, situado no Sudeste do Brasil. Para apresentação de todos os resultados, utilizaram-se as médias, desvios padrão e percentis. RESULTADOS: A dilatação vascular dependente do endotélio 90 segundos pós-liberação do manguito foi de 20,9±6,7 por cento [média mais ou menos 1 desvio padrão (DP)] e o 10° percentil ficou em 12,5 por cento no sexo masculino e de 18,8±12,9 por cento DP e o 10° percentil em 6,6 por cento no sexo feminino. Os valores no grupo todo foram de 19,3±11,7 por cento e 6,7 por cento, respectivamente. CONCLUSÃO: O 10° percentil (6,7 por cento) da curva de distribuição dos valores de dilatação vascular dependente do endotélio, em adolescentes do presente estudo, pode ser considerado como limite inferior da normalidade. O conhecimento desse limite é importante para o diagnóstico de disfunções endoteliais que aparecem antes das doenças cardiovasculares.


Assuntos
Adolescente , Feminino , Humanos , Masculino , Endotélio Vascular/fisiologia , Hipertensão/fisiopatologia , Vasodilatação/fisiologia , Índice de Massa Corporal , Peso ao Nascer/fisiologia , Pressão Sanguínea/fisiologia , Estudos Transversais , Endotélio Vascular , Hipertensão , Fatores de Risco
13.
J Thorac Imaging ; 20(2): 74-80, 2005 May.
Artigo em Inglês | MEDLINE | ID: mdl-15818205

RESUMO

OBJECTIVES: The purpose of this study was to evaluate high-resolution CT findings in 7 patients with Churg-Strauss syndrome and to compare the CT with the histopathologic findings. MATERIALS AND METHODS: High-resolution CT scans of 7 asthmatic patients (4 women, 3 men, age range, 34-62 years, mean 49 years) with Churg-Strauss syndrome were reviewed by 2 observers. Histologic specimens of lung obtained at surgical (n = 3) or transbronchial (n = 3) biopsy or autopsy (n = 1) were reviewed by an expert lung pathologist. The diagnosis of Churg-Strauss was based on clinical, laboratory, and histologic findings. RESULTS: Parenchymal and airway abnormalities included ground-glass opacities (n = 5), areas of air-space consolidation (n = 4), centrilobular nodules (n = 5), nodules 1-3 cm in diameter (n = 3), interlobular septal thickening (n = 4), bronchial wall thickening (n = 4), and areas of atelectasis (n = 1). Surgical biopsy (n = 3) and autopsy (n = 1) specimens demonstrated airspace disease in 3 patients, interlobular septal thickening in 3 patients, and airway abnormalities in 2 patients. Histologically, the airspace disease included eosinophilic pneumonia (n = 2) and small foci of organizing pneumonia (n = 1). The septal thickening was due to edema combined with numerous (n = 2) or few (n = 1) eosinophils. The airway abnormalities (n = 2) included muscle hypertrophy and large airway wall necrosis (n = 1) and eosinophilic infiltration of the airway walls (n = 1). Transbronchial biopsy (n = 3) demonstrated increased eosinophils. CONCLUSION: The main high-resolution CT findings of Churg-Strauss syndrome consist of airspace consolidation or ground-glass opacities, septal lines, and bronchial wall thickening. These reflect the presence of eosinophilic infiltration of the airspaces, interstitium, and airways, and interstitial edema.


Assuntos
Síndrome de Churg-Strauss/diagnóstico , Síndrome de Churg-Strauss/patologia , Tomografia Computadorizada por Raios X/métodos , Adulto , Asma/complicações , Biópsia/métodos , Síndrome de Churg-Strauss/complicações , Eletrocardiografia/métodos , Eosinófilos/diagnóstico por imagem , Feminino , Insuficiência Cardíaca/complicações , Insuficiência Cardíaca/diagnóstico , Humanos , Pulmão/diagnóstico por imagem , Pulmão/patologia , Pulmão/cirurgia , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Derrame Pleural/complicações , Derrame Pleural/diagnóstico , Estudos Retrospectivos
14.
AJR Am J Roentgenol ; 182(5): 1251-4, 2004 May.
Artigo em Inglês | MEDLINE | ID: mdl-15100127

RESUMO

OBJECTIVE: The objective of this study was to assess the diagnostic value of attenuation measurements of the kidney on unenhanced helical CT in patients with obstructive ureterolithiasis. MATERIALS AND METHODS: Consecutive unenhanced helical CT scans of patients referred for acute unilateral renal colic were retrospectively reviewed. Patients with CT evidence of other urinary system diseases were excluded. Included scans (n = 145) were assessed for ureteral stone and secondary signs of obstruction such as unilateral collecting system or ureteral dilatation, perinephric stranding, and periureteral edema. Renal attenuation in Hounsfield units was measured in the upper, middle, and lower portions of the parenchyma, and a mean value was determined for each kidney. RESULTS: Ureteral stones were present in 76 patients. Renal attenuation on the side with lithiasis was lower than on the opposite kidney: 27.2 +/- 3.9 H vs 32.6 +/- 3.4 H (p < 0.001). Attenuation differences between kidneys were higher for patients with ureterolithiasis: 5.4 +/- 3.2 H (range, -3.3 to 13.0 H) versus 1.2 +/- 1.0 H (range, 0-4.7 H) (p < 0.001). An attenuation difference between kidneys greater than or equal to 5.0 H had 61% sensitivity, 100% specificity, 100% positive predictive value, 69% negative predictive value, and 79% accuracy for diagnosis of ureteral lithiasis. CONCLUSION: Attenuation difference between kidneys greater than or equal to 5.0 H was a valuable sign and had diagnostic performance similar to other secondary signs of obstructive ureterolithiasis. Furthermore, attenuation difference had the advantage of being an objective, measurement-based indicator.


Assuntos
Tomografia Computadorizada por Raios X , Cálculos Ureterais/diagnóstico por imagem , Obstrução Ureteral/diagnóstico por imagem , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Retrospectivos , Cálculos Ureterais/complicações , Obstrução Ureteral/etiologia
15.
Radiol. bras ; 34(6): 323-326, nov.-dez. 2001. ilus, tab
Artigo em Português | LILACS | ID: lil-322617

RESUMO

OBJETIVO: Determinar a freqüência de identificação das estruturas músculo-ligamentares do assoalho pélvico por meio de exames de ressonância magnética e avaliar o índice de concordância entre os observadores. MÉTODO: Estudo prospectivo em 20 voluntárias assintomáticas, idade de 20 a 80 anos (média de 50 anos). Realizados exames de ressonância magnética pélvica (1,5 T) nas seqüências turbo spin-eco ponderadas em T1 e T2 nos planos axial e sagital. Os exames foram avaliados por dois observadores independentes, que procuraram identificar os músculos levantador do ânus (músculos coccígeo, pubococcígeo, iliococcígeo e puborretal), obturador interno e compressor da uretra e os ligamentos pubovesical e pubouretral. Os resultados foram comparados com base na freqüência de identificação das estruturas anatômicas e na concordância entre os observadores (índice kappa - k). RESULTADOS: A freqüência de identificação das estruturas variou de 50 por cento a 100 por cento, sendo pouco inferior para os ligamentos. A concordância interobservador na identificação das estruturas foi a seguinte: músculos levantador do ânus e obturador interno (k=1), pubococcígeo (k=0,62), iliococcígeo (k=0,86), puborretal (k=0,27), coccígeo (k=0) e compressor da uretra (k=1), e ligamentos pubovesical (k=0,50) e pubouretral (k=0,58). CONCLUSÃO: A ressonância magnética de pelve permite identificar as principais estruturas músculo-ligamentares do assoalho pélvico na grande maioria dos indivíduos, com boa concordância interobservador.


Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Imageamento por Ressonância Magnética , Diafragma da Pelve/anatomia & histologia , Reprodutibilidade dos Testes
16.
Rev. imagem ; 21(1): 7-13, jan.-mar. 1999. tab
Artigo em Português | LILACS | ID: lil-259932

RESUMO

Objetivo - Avaliar as decisöes tomadas por radiologistas em relaçäo à escolha do tipo de meio de contraste intravenoso (agente näo-iônico versus agente iônico convencional) e a freqüência do uso de esquemas profiláticos. Material e métodos - Um questionário, baseado em estudo publicado na literatura internacional, foi aplicado durante a 27ª Jornada Paulista de Radiologia, 1997. Foram coletados 432 questionários, sendo aproveitados para o estudo 187 (43 por cento). Resultados - A maioria dos radiologistas utiliza meio de contraste näo-iônico de forma seletiva. A profilaxia com corticosteróides e anti-histamínicos em pacientes com risco de reaçöes adversas é usada com freqüência similar, tanto nos casos de uso seletivo ou universal de meio de contraste näo-iônico. Há grande diversidade dos esquemas de pré-medicaçäo (tipo de droga usada e posologia), sendo que os anti-histamínicos, apesar de bastante usados em associaçäo com corticosteróides, säo raramente utilizados de forma isolada. Conclusäo - O meio de contraste näo-iônico é usado seletivamente pela maioria dos radiologistas que escolhem este tipo de contraste em pacientes que consideram com risco de reaçöes adversas. Os esquemas de pré-medicaçäo säo amplamente utilizados, havendo grande heterogeneidade quanto ao tipo de esquema utilizado para cada situaçäo clínica proposta


Assuntos
Humanos , Meios de Contraste/efeitos adversos , Pré-Medicação/normas , Inquéritos e Questionários , Radiografia/normas , Corticosteroides/uso terapêutico , Brasil , Cimetidina/uso terapêutico , Meios de Contraste/administração & dosagem , Meios de Contraste/classificação , Antagonistas dos Receptores Histamínicos H1/uso terapêutico , Antagonistas dos Receptores H2 da Histamina/uso terapêutico , Compostos de Iodo , Compostos de Iodo/efeitos adversos
17.
Rev. imagem ; 13(3/4): 149-51, jul.-dez. 1991. ilus
Artigo em Português | LILACS | ID: lil-126562

RESUMO

O aneurisma da artéria hepática é uma lesäo rara que apresenta grande tendência à ruptura espontânea, quando entäo produz sintomas mais evidentes e maior índice de mortalidade. A etiologia mais comum é a arteriosclerose, seguida pelos traumas (inclusive cirúrgicos). Neste artigo relatamos um caso de aneurisma da artéria hepática associado a aneurisma dissecante da aorta abdominal em um paciente idoso, hipertenso, referindo queixas vagas de epigastralgia. O estudo ultra-sonográfico mostrou massa heterogênea sólida, com áreas hipoecóicas em seu interior, localizada junto ao hilo hepático. A tomografia computadorizada revelou formaçäo arredondada sólida com halo calcificado e áreas centrais com realce vascular após a administraçäo do contraste. Também observou-se dilataçäo com dissecçäo da aorta abdominal. A importância da realizaçäo dos métodos näo invasivos, como o ultra-som e tomografia computadorizada, está no diagnóstico precoce e na avaliaçäo de possíveis complicaçöes do aneurisma da artéria hepática


Assuntos
Humanos , Masculino , Idoso , Aneurisma/diagnóstico , Aneurisma da Aorta Abdominal/diagnóstico , Artéria Hepática , Dissecção Aórtica/complicações , Dissecção Aórtica/diagnóstico , Aneurisma , Aneurisma/complicações , Aneurisma da Aorta Abdominal , Aneurisma da Aorta Abdominal/complicações , Artéria Hepática , Tomografia Computadorizada por Raios X
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