Early diagnosis of cardiac implantable electronic device generator pocket infection using ¹8F-FDG-PET/CT.

AIMS: To examine the utility of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in the early diagnosis of cardiac implantable electronic device (CIED) generator pocket infection. METHODS AND RESULTS: A total of 86 patients with CIEDs were evaluated with (18)F-FDG PET/CT imaging: 46 with suspected generator pocket infection and 40 without any history of infection. (18)F-FDG activity in the region of the generator pocket was expressed as a semi-quantitative ratio (SQR)-defined as the maximum count rate around the CIED divided by the mean count rate between normal right and left lung parenchyma. All patients underwent standard clinical management, independent of the PET/CT result. Patients with suspected generator pocket infection that required CIED extraction (n = 32) had significantly higher (18)F-FDG activity compared with those that did not (n = 14), and compared with controls (n = 40) [SQR: 4.80 (3.18-7.05) vs. 1.40 (0.88-1.73) vs. 1.10 (0.98-1.40), respectively; P < 0.001]. On receiver operator characteristic analysis, SQR had a high diagnostic accuracy (area under curve = 0.98) for the early identification of patients with confirmed infection (i.e. those ultimately needing extraction)-with an optimal SQR cut-off value of >2.0 (sensitivity = 97%; specificity = 98%). CONCLUSION: This study highlights the potential benefits of evaluating patients with suspected CIED generator pocket infection using (18)F-FDG PET/CT. In this study, (18)F-FDG PET/CT had a high diagnostic accuracy in the early diagnosis of CIED generator pocket infection, even where initial clinical signs were underwhelming.

Changes in the appearance of attenuation artefacts due to change in posture in myocardial perfusion imaging.

OBJECTIVE: Traditional supine imaging with arms raised for myocardial perfusion imaging (MPI) is uncomfortable for many cardiac patients. Seated imaging with arms resting at shoulder level is an attractive alternative. This study aimed to compare the patient comfort and image appearance of seated MPI with traditional supine MPI. METHOD: Sixty-seven patients (41 male, 26 female; body mass index (BMI) between 20.4 and 45.4) were imaged seated on the Mediso Nucline Cardiodesk gamma camera and supine on the GE Millennium VG gamma camera using our standard departmental MPI protocol. The images from each were compared and a questionnaire was used to determine patients' views of the relative comfort of the procedures. RESULTS: Strong patient preference for seated imaging was demonstrated. Perfusion patterns on seated and supine images were strikingly different with the changes seen being greatest and very striking in obese females with seven out of 12 (58%) showing changes of more than two grades. For a subset of 17 normal weight (BMI <25) male patients a significant reduction (P<0.05) in defect size was found in the inferior segment only, signifying a reduction in diaphragmatic attenuation in the seated position. CONCLUSION: Seated imaging offers considerable advantages in terms of patient acceptability. For non-obese men seated imaging also offers advantages in terms of reduced diaphragmatic attenuation artefacts. However, women and also obese men show significant differences in perfusion pattern from traditional supine imaging. A facility for accurate attenuation correction of seated images could provide useful information to elucidate these effects.