Using Real-Time fMRI Neurofeedback to Modulate M1-Cerebellum Connectivity.

Objective: The potential of neurofeedback to alter the M1-cerebellum connectivity was explored using motor imagery-based rt-fMRI. These regions were chosen due to their importance in motor performance and motor rehabilitation. Methods: Four right-handed individuals were recruited to examine the potential to change the M1-cerebellum neurofeedback link. The University of Glasgow Cognitive Neuroimaging Centre used a 3T MRI scanner from January 2019 to January 2020 to conduct this prospective study. Everyone participated in each fMRI session, which included six NF training runs. Participants were instructed to imagine complicated hand motions during the NF training to raise a thermometer bar's height. To contrast the correlation coefficients between the initial and last NF runs, a t-test was performed post hoc. Results: The neurofeedback connection between M1 and the cerebellum was strengthened in each participant. Motor imagery strategy was a significant task in training M1-cerebellum connectivity as participants used it successfully to enhance the activation level between these regions during M1-cerebellum modulation using real-time fMRI. The t-test and linear regression, on the other hand, showed this increase to be insignificant. Conclusion: A novel technique to manipulate M1-cerebellum connectivity was discovered using real-time fMRI NF. This study showed that each participant's neurofeedback connectivity between M1 and cerebellum was enhanced. This increase, on the other hand, was insignificant statistically. The results showed that the connectivity between both areas increased positively. Through the integration of fMRI and neurofeedback, M1-cerebellum connectivity can be positively affected.

Functional Localizers for Motor Areas of the Brain Using fMRI.

Neuroimaging researchers increasingly take advantage of the known functional properties of brain regions to localize motor regions in the brain and investigate changes in their activity under various conditions. Using this noninvasive functional MRI (fMRI) method makes it possible to identify and localize brain activation. There are many localizers that can be used to identify brain areas, namely, motor areas such as functional localizer, anatomical localizer, or Atlas mask. Eighteen right-handed participants were recruited for this research to test the reliability of five localizers for primary motor cortex (M1), supplementary motor area (SMA), premotor cortex (PMC), motor cerebellum, and motor thalamus. Motor execution task, namely, hand clenching was used to activate M1, SMA, and motor cerebellum. A combined action observation and motor imagery (AOMI) task was used to functionally activate PMC. Finally, a mask based on Talairach coordinates Atlas was created and used to identify the motor thalamus. Our results show that all localizers were successfully activated in the desired regions of interest. Motor execution successfully activated M1, SMA, and motor cerebellum. A novel localizer based on AOMI was successfully activated in PMC, and the motor thalamus mask obtained from the thalamus mask was successfully implemented on each participant. In conclusion, all five localizers tested in this research were reliable and can be used for rt-fMRI neurofeedback research to define the regions of interest.