RESUMO
We report a case of an 86-year-old woman admitted to the hospital with rhabdomyolysis and acute kidney injury 3 weeks after starting sitagliptin while on long-term atorvastatin therapy. She also had low levels of 25-hydroxyvitamin D and mild chronic kidney disease, which may have contributed to the development of rhabdomyolysis. A review of the literature reveals four previous reports of this drug interaction in elderly patients, some with underlying kidney disease.
Assuntos
Injúria Renal Aguda/sangue , Atorvastatina/efeitos adversos , Inibidores de Hidroximetilglutaril-CoA Redutases/efeitos adversos , Rabdomiólise/sangue , Fosfato de Sitagliptina/efeitos adversos , Vitamina D/análogos & derivados , Injúria Renal Aguda/induzido quimicamente , Idoso de 80 Anos ou mais , Feminino , Humanos , Rabdomiólise/induzido quimicamente , Rabdomiólise/diagnóstico , Vitamina D/sangueRESUMO
Clostridium difficile infections (CDI) are increasing in incidence and severity. Leukemoid reaction is rarely seen with CDI, and indicates severe disease with grave prognosis. We present an elderly female who developed leukemoid reaction in response to CDI. The patient died despite early antibiotic therapy with surgical evaluation.