Vancomycin flushing syndrome in orthopaedic practice: A case report.

BACKGROUND: Vancomycin flushing syndrome (VFS), also known as red man syndrome, is an allergic reaction to vancomycin. It typically presents as a rash on the face, neck, and upper torso after intravenous administration of vancomycin. VFS is blamed on rapid intravenous infusion of vancomycin during management and rarely happens after local use. A review of the literature showed that in the last 23 years, 4 such cases have been reported. Here, we add another case of VFS developed after slow local absorption of vancomycin in cement beads. CASE SUMMARY: A 44-year-old male with a known case of hypertension, no history of allergies to medications, and a history of chronic osteomyelitis of the right tibia with discharging sinus over the anterolateral aspect of the leg. The pus culture grew Staphylococcus aureus, which was sensitive to clindamycin and vancomycin. The patient underwent irrigation and debridement with the placement of vancomycin cement beads made from 4 g of vancomycin powder and 40 g of polymethyl methacrylate. Three hours postoperatively, the patient developed a pruritic, erythematous, macular rash predominantly on his face, neck, chest, and lower extremities and to a lesser extent his upper extremities. A diagnosis of VFS was made and was successfully treated with cetirizine (10 mg, oral) and methylprednisolone sodium succinate (125 mg, intravenous). The patient continued to have itching with a facial rash for 12 h with gradual improvement. A decision was made to not remove the beads as the patient continued to improve. Gradually, the rash disappeared after 96 h with no further sequela. CONCLUSION: VFS can occur not only after rapid intravenous injection of vancomycin but also with local release, as in our case. As orthopaedic surgeons routinely use vancomycin with polymethyl methacrylate in chronic osteomyelitis and revision arthroplasty, they should be aware of such a complication occurring.

Severe Traumatic Brain Injury Presenting with Wide Complex Tachycardia: a Case Report.

Background: Ventricular tachycardia (VT) is an abnormal heart rhythm that can lead to pump failure and hypoperfusion. Its causes, presentation, and treatment are well established in the literature. However, the VT treatment algorithm is based on non-traumatic patients. Due to different pathophysiology and presentation, treating VT in trauma patients should be different. Objective: The main purpose is to emphasize the approach to treating VT in severe head trauma patients. Case presentation: This case is a unique presentation of severe head trauma with a paucity of treatment approaches in the literature. In this article, we present a case of a middle-aged male patient presented to a level one trauma center with a history of falls from 2 stories height with a Glasgow Coma Scale (GCS) of 3/15. ATLS approach was followed in treating this patient, his rhythm strip showed a wide complex regular rhythm, likely representing a VT with a pulse. The patient was treated as unstable because of a decreased level of consciousness. A 100 J synchronized cardioversion was given without restoration of normal sinus rhythm, followed by Mannitol 1g/kg, treating the possibility of high intracranial pressure (ICP), after which his rhythm was restored to sinus. Conclusion: The restoration of sinus rhythm after treating the possibility of high ICP suggests that the cause of VT in this severe TBI patient was the high ICP.

Completely Displaced Femoral Neck Stress Fracture in a Young Male Soldier With Almost No Functional Impact: A Case Report.

Stress fracture in general is a well-known condition that can be found commonly in healthy athletes and military personnel. These fractures occur due to bone fatigue in response to the repetitive stress of exercise. Although few reports on stress fractures among military personnel and active young athletes can be found in previous literature, we present this case report of a young military soldier that had a completely displaced neck of femur fracture with no functional limitation for seven days prior to seeking medical advice; the patient was operated on and followed for three years after and did not develop complications associated with this kind of fracture. A reduction of neck of femur fracture and fixation in valgus position to maintain good reduction with weight-bearing as done in our case have assisted in reducing avascular necrosis (AVN) risk despite the high displacement and delayed operative intervention due to the patient's late presentation.

A Retrospective Analysis from A Single Center Perspective On Complications After Fixing Distal Radius Fracture In Pediatric Population.

Background: The Distal radius fractures in the pediatric age group have similar complications to any other fracture. One interpretation of the high fracture incidence in the distal third of the radius is the relative weakness of the metaphyseal part. Objective: The aim of this study is to provide an evaluation of Surgical complications of distal radius through satisfactory reduction and proper fixation by K-wires through bone growth plates. Methods: A retrospective single-center study in a tertiary hospital in Eastern Saudi Arabia from 2000 to 2021, using the hospital's electronic records system. The Inclusion criteria of this study involve all distal radius fracture cases who underwent surgical fixation by k-wire or plating system and are up to 14 years old. The exclusion criteria include loss of follow-up, incomplete data, and age of more than 14 years. Results: the study included 103 patients. The side of injury was almost equally distributed between the left and right sides. The odds of having at least one complication increase by 2.5 folds if the site of fracture is at the diaphysis. Further, if the distance of the fracture line to the epiphysis is more than 20 mm, the odds of reporting at least one complication post-procedure is 4.4 times higher than if it was at the level of the epiphysis. The majority of diaphyseal fractures required less than 6 weeks for radiological healing, which is significantly different from other sites which were evaluated. Conclusion: Complications of distal radius fracture due to Surgical intervention could be confounded by the complexity of the fracture itself. In our study, we found the distance of the fracture from the physis was inversely proportional to the likelihood of complications. For a comprehensive appreciation of physeal plate, we recommend extended follow-up for those who present with signs of severe distal radius fracture, especially in case of associated ulnar fracture.

Epidemiology, Etiology, Timing and Severity of Open Fracture - a Five Years Review From a Tertiary Trauma Center, Eastern Province, Saudi Arabia.

Background: Open fractures are severe injuries resulting from the bone breaking through the skin, and they have a negative impact on patients' physical, mental, and financial well-being as well as that of the healthcare system. The incidence of open fractures varies globally. These injuries can lead to prolonged disability, increased healthcare costs, and psychological distress. The Gustilo-Anderson classification system is used to classify open fractures into three categories which surgeons use as an index for the severity of an injury and as a prognostic tool. Management involves a multidisciplinary approach, focusing on preventing infection, promoting wound healing, and restoring function. Objective: The objective of this study is to provide statistics on the epidemiology of open fractures presented to the emergency department to be used later to create management protocols. Methods: This 5-year retrospective observational analysis of open fracture patients at King Fahad Hospital, a tertiary trauma care institute in Alkhobar from 2018-2023, aimed to understand socio-demographics, injury mechanisms, fracture patterns, and timing. Data were collected electronically, and found 373 cases which were reviewed, and only 138 open fractures fit our inclusion and exclusion criteria and were added to the study. Results: The study analyzed 138 openly fractured bones in 132 patients aged 2 to 68. Most bones affected were in the lower extremities, the most common being the forefoot bones. The most common mode of injury was a motorbike, followed by MVA. The most common Gustilo type was type 2, with no significant correlation between gender and severity. Musculoskeletal system injury was the highest associated system. Furthermore, we observe a slight increase in cases in Winter/Fall weather seasons. Conclusion: Total amount of 84.8% of patients with open fractures are men, compared to 15.2% of women. The average age of patients is 25.6 ± 15.6 years. Motorbike accidents, then MVA, are the two leading causes of open fractures. Weather seasons, especially in fall and winter, may also contribute to an increase in open fractures. We found that type 2 is the most common Gustilo type among the injured bones (59.1%).

Morbidity and mortality after fragility hip fracture in a Saudi Arabian population: Report from a single center.

Objective To determine the functional morbidity and mortality after fragility hip fracture and compare the mortality with three other common diseases. Methods Data were collected from patients admitted to King Fahd Hospital of the University, AlKhobar from January 2010 to December 2014. Demographic data included the preoperative American Society of Anesthesiologists (ASA) score as assessed by the anesthetist and the type of surgery. Personal and telephone interviews were performed, and data were entered into a database and analyzed. Results We identified 203 patients with fragility proximal femoral fractures, and the data of 189 patients (109 male, 80 female; average age, 66.90 ± 13.43 years) were available for analysis. The overall mortality rate was 26.98% (51 patients). The mortality rate was significantly higher among patients with an ASA score of 4 (36.36%) than 1 (20.45%). With respect to morbidity, only 48.23% of patients were able to return to their pre-fracture status; 32.35% of those who required assisted walking and 83.4% of those who required a wheelchair became bedridden. Conclusions Our data demonstrate that patients with fragility hip fractures have high morbidity and a mortality rate approaching 30%. Age and the ASA score significantly influence this high mortality rate.