Multimodal CNN-DDI: using multimodal CNN for drug to drug interaction associated events.

Drug-to-drug interaction (DDIs) occurs when a patient consumes multiple drugs. Therefore, it is possible that any medication can influence other drugs' effectiveness. The drug-to-drug interactions are detected based on the interactions of chemical substructures, targets, pathways, and enzymes; therefore, machine learning (ML) and deep learning (DL) techniques are used to find the associated DDI events. The DL model, i.e., Convolutional Neural Network (CNN), is used to analyze the DDI. DDI is based on the 65 different drug-associated events, which is present in the drug bank database. Our model uses the inputs, which are chemical structures (i.e., smiles of drugs), enzymes, pathways, and the target of the drug. Therefore, for the multi-model CNN, we use several layers, activation functions, and features of drugs to achieve better accuracy as compared to traditional prediction algorithms. We perform different experiments on various hyperparameters. We have also carried out experiments on various iterations of drug features in different sets. Our Multi-Modal Convolutional Neural Network - Drug to Drug Interaction (MCNN-DDI) model achieved an accuracy of 90.00% and an AUPR of 94.78%. The results showed that a combination of the drug's features (i.e., chemical substructure, target, and enzyme) performs better in DDIs-associated events prediction than other features.

Energy efficient virtual machines placement in cloud datacenters using genetic algorithm and adaptive thresholds.

Cloud computing platform provides on-demand IT services to users and advanced the technology. The purpose of virtualization is to improve the utilization of resources and reduce power consumption. Energy consumption is a major issue faced by data centers management. Virtual machine placement is an effective technique used for this purpose. Different algorithms have been proposed for virtual machine placement in cloud environments. These algorithms have considered different parameters. It is obvious that improving one parameter affects other parameters. There is still a need to reduce energy consumption in cloud data centers. Data centers need solutions that reduce energy consumption without affecting other parameters. There is a need to device solutions to effectively utilize cloud resources and reduce energy consumption. In this article, we present an algorithm for Virtual Machines (VMs) placement in cloud computing. The algorithm uses adaptive thresholding to identify over utilized and underutilized hosts to reduce energy consumption and Service Level Agreement (SLA) violations. The algorithm is validated with simulations and comparative results are presented.

Deep learning ensemble 2D CNN approach towards the detection of lung cancer.

In recent times, deep learning has emerged as a great resource to help research in medical sciences. A lot of work has been done with the help of computer science to expose and predict different diseases in human beings. This research uses the Deep Learning algorithm Convolutional Neural Network (CNN) to detect a Lung Nodule, which can be cancerous, from different CT Scan images given to the model. For this work, an Ensemble approach has been developed to address the issue of Lung Nodule Detection. Instead of using only one Deep Learning model, we combined the performance of two or more CNNs so they could perform and predict the outcome with more accuracy. The LUNA 16 Grand challenge dataset has been utilized, which is available online on their website. The dataset consists of a CT scan with annotations that better understand the data and information about each CT scan. Deep Learning works the same way our brain neurons work; therefore, deep learning is based on Artificial Neural Networks. An extensive CT scan dataset is collected to train the deep learning model. CNNs are prepared using the data set to classify cancerous and non-cancerous images. A set of training, validation, and testing datasets is developed, which is used by our Deep Ensemble 2D CNN. Deep Ensemble 2D CNN consists of three different CNNs with different layers, kernels, and pooling techniques. Our Deep Ensemble 2D CNN gave us a great result with 95% combined accuracy, which is higher than the baseline method.

A transformer fine-tuning strategy for text dialect identification.

Online medical consultation can significantly improve the efficiency of primary health care. Recently, many online medical question-answer services have been developed that connect the patients with relevant medical consultants based on their questions. Considering the linguistic variety in their question, social background identification of patients can improve the referral system by selecting a medical consultant with a similar social origin for efficient communication. This paper has proposed a novel fine-tuning strategy for the pre-trained transformers to identify the social origin of text authors. When fused with the existing adapter model, the proposed methods achieve an overall accuracy of 53.96% for the Arabic dialect identification task on the Nuanced Arabic Dialect Identification (NADI) dataset. The overall accuracy is 0.54% higher than the previous best for the same dataset, which establishes the utility of custom fine-tuning strategies for pre-trained transformer models.

Integrated Bayesian and association-rules methods for autonomously orienting COVID-19 patients.

The coronavirus infection continues to spread rapidly worldwide, having a devastating impact on the health of the global population. To fight against COVID-19, we propose a novel autonomous decision-making process which combines two modules in order to support the decision-maker: (1) Bayesian Networks method-based data-analysis module, which is used to specify the severity of coronavirus symptoms and classify cases as mild, moderate, and severe, and (2) autonomous decision-making module-based association rules mining method. This method allows the autonomous generation of the adequate decision based on the FP-growth algorithm and the distance between objects. To build the Bayesian Network model, we propose a novel data-based method that enables to effectively learn the network's structure, namely, MIGT-SL algorithm. The experimentations are performed over pre-processed discrete dataset. The proposed algorithm allows to correctly generate 74%, 87.5%, and 100% of the original structure of ALARM, ASIA, and CANCER networks. The proposed Bayesian model performs well in terms of accuracy with 96.15% and 94.77%, respectively, for binary and multi-class classification. The developed decision-making model is evaluated according to its utility in solving the decisional problem, and its accuracy of proposing the adequate decision is about 97.80%.

Machine learning techniques for identification of carcinogenic mutations, which cause breast adenocarcinoma.

Breast adenocarcinoma is the most common of all cancers that occur in women. According to the United States of America survey, more than 282,000 breast cancer patients are registered each year; most of them are women. Detection of cancer at its early stage saves many lives. Each cell contains the genetic code in the form of gene sequences. Changes in the gene sequences may lead to cancer. Replication and/or recombination in the gene base sometimes lead to a permanent change in the nucleotide sequence of the genome, called a mutation. Cancer driver mutations can lead to cancer. The proposed study develops a framework for the early detection of breast adenocarcinoma using machine learning techniques. Every gene has a specific sequence of nucleotides. A total of 99 genes are identified in various studies whose mutations can lead to breast adenocarcinoma. This study uses the dataset taken from 4127 human samples, including men and women from more than 12 cohorts. A total of 6170 mutations in gene sequences are used in this study. Decision Tree, Random Forest, and Gaussian Naïve Bayes are applied to these gene sequences using three evaluation methods: independent set testing, self-consistency testing, and tenfold cross-validation testing. Evaluation metrics such as accuracy, specificity, sensitivity, and Mathew's correlation coefficient are calculated. The decision tree algorithm obtains the best accuracy of 99% for each evaluation method.

Addressing Challenges of Distance Learning in the Pandemic with Edge Intelligence Enabled Multicast and Caching Solution.

The COVID-19 pandemic has affected the world socially and economically changing behaviors towards medical facilities, public gatherings, workplaces, and education. Educational institutes have been shutdown sporadically across the globe forcing teachers and students to adopt distance learning techniques. Due to the closure of educational institutes, work and learn from home methods have burdened the network resources and considerably decreased a viewer's Quality of Experience (QoE). The situation calls for innovative techniques to handle the surging load of video traffic on cellular networks. In the scenario of distance learning, there is ample opportunity to realize multi-cast delivery instead of a conventional unicast. However, the existing 5G architecture does not support service-less multi-cast. In this article, we advance the case of Virtual Network Function (VNF) based service-less architecture for video multicast. Multicasting a video session for distance learning significantly lowers the burden on core and Radio Access Networks (RAN) as demonstrated by evaluation over a real-world dataset. We debate the role of Edge Intelligence (EI) for enabling multicast and edge caching for distance learning to complement the performance of the proposed VNF architecture. EI offers the determination of users that are part of a multicast session based on location, session, and cell information. Moreover, user preferences and network's contextual information can differentiate between live and cached access patterns optimizing edge caching decisions. While exploring the opportunities of EI-enabled distance learning, we demonstrate a significant reduction in network operator resource utilization and an increase in user QoE for VNF based multicast transmission.

Equity distribution of quality evaluation reports to doctors in health care organizations.

There are volumes of patient reports generated in any healthcare organization daily. The reports can be very lengthy or of few pages. Maintaining records of patients is essential for ensuring quality medical care. Doctors, apart from their routine activities, are also responsible to sort, examine and archive the generated reports. However, this process consumes doctors' time, who are already hard-pressed for time. The objective of this study is to search for a method that can assign reports to doctors to ensure equitable and fair distribution of the overall workload. As a part of the solution, a mathematical model will be proposed to perform different developed heuristics. An experimental evaluation using different classes with a total of 2,450 different instances will be tested to measure the performance of the developed heuristics in terms of, elapsed time and gap value calculations. The clustering heuristics which is based on two groups is the best heuristic with 96.1% for the small instances and 98% for the big scale instances. The contribution of this work is based on employing dispatching rules with several variants; randomization approach, clustering methods; probabilistic method, and iterative methods approach to assign all given reports to doctors while ensuring the equitable distribution of the paper workload.