Drug carrier wonders: Synthetic strategies of zeolitic imidazolates frameworks (ZIFs) and their applications in drug delivery and anti-cancer activity.

With the rapid advancement of nanotechnology, stimuli-responsive nanomaterials have emerged as a feasible choice for the designing of controlled drug delivery systems. Zeolitic imidazolates frameworks are a subclass of Metal-organic frameworks (MOFs) that are recognized by their excellent porosity, structural tunability and chemical modifications make them promising materials for loading targeted molecules and therapeutics agents. The biomedical industry uses these porous materials extensively as nano-carriers in drug delivery systems. These MOFs not only possess excellent targeted imaging ability but also cause the death of tumor cells drawing considerable attention in the current framework of anticancer drug delivery systems. In this review, the outline of stability, porosity, mechanism of encapsulation and release of anticancer drug have been reported extensively. In the end, we also discuss a brief outline of current challenges and future perspectives of ZIFs in the biomedical world.

Mo-based MXenes: Synthesis, properties, and applications.

Ti-MXene allows a range of possibilities to tune their compositional stoichiometry due to their electronic and electrochemical properties. Other than conventionally explored Ti-MXene, there have been ample opportunities for the non-Ti-based MXenes, especially the emerging Mo-based MXenes. Mo-MXenes are established to be remarkable with optoelectronic and electrochemical properties, tuned energy, catalysis, and sensing applications. In this timely review, we systematically discuss the various organized synthesis procedures, associated experimental tunning parameters, physiochemical properties, structural evaluation, stability challenges, key findings, and a wide range of applications of emerging Mo-MXene over Ti-MXenes. We also critically examined the precise control of Mo-MXenes to cater to advanced applications by comprehensively evaluating the summary of recent studies using artificial intelligence and machine learning tools. The critical future perspectives, significant challenges, and possible outlooks for successfully developing and using Mo-MXenes for various practical applications are highlighted.

Titanium doped cobalt ferrite fabricated graphene oxide nanocomposite for efficient photocatalytic and antibacterial activities.

Dyes and microbes are the main sources of water pollution and their treatment with titanium doped cobalt ferrite nanoparticles (CoTixFe2-xO4 NPs) is highly challenging due to the recombination ability of their electron-hole pairs which could be mitigated by making their composite with graphene oxide (GO). In the present study, titanium doped cobalt ferrite was fabricated on GO (CoTi0.2Fe1.8O4/GO NC) via the facile ultrasonication method and its confirmation was done by various analytical studies. Homogeneous dispersion of spherical CoTi0.2Fe1.8O4 NPs on the GO surface was realized by SEM analysis. Excellent crystallinity was corroborated by XRD while a Zeta Potential value -21.52 mV depicted exceptional stability. The photocatalytic power of CoTi0.2Fe1.8O/GO NC against Congo Red (CR) dye showed 91% degradation efficiency after 120 min visible light irradiation under optimum conditions of pH 9 and dye concentration 1 mg L-1 which was reasonably higher as compared to bare CoTi0.2Fe1.8O NPs (78% degradation efficiency). The improved photocatalytic performance is accredited to its narrow bandgap value (1.07 eV) and enhanced charge separation as indicated by the Tauc plot and Photoluminescence analysis, respectively. Additionally, CoTi0.2Fe1.8O/GO NC could be readily regenerated and reused five times with only ∼2% performance loss. Meanwhile, MICs of CoTi0.2Fe1.8O4/GO NC against P. aeruginosa and S. aureus were 0.046 and 0.093 mg mL-1 while MBCs were 0.093 and 0.187 mg mL-1, respectively. Thereby, optimized NC can open new avenues for the degradation of dyes from polluted water besides acting as a promising antimicrobial agent by rupturing the cell walls of pathogens.

2D MXene-Based Biosensing: A Review.

MXene emerged as decent 2D material and has been exploited for numerous applications in the last decade. The remunerations of the ideal metallic conductivity, optical absorbance, mechanical stability, higher heterogeneous electron transfer rate, and good redox capability have made MXene a potential candidate for biosensing applications. The hydrophilic nature, biocompatibility, antifouling, and anti-toxicity properties have opened avenues for MXene to perform in vitro and in vivo analysis. In this review, the concept, operating principle, detailed mechanism, and characteristic properties are comprehensively assessed and compiled along with breakthroughs in MXene fabrication and conjugation strategies for the development of unique electrochemical and optical biosensors. Further, the current challenges are summarized and suggested future aspects. This review article is believed to shed some light on the development of MXene for biosensing and will open new opportunities for the future advanced translational application of MXene bioassays.

Functionalized thiazolidone-decorated lanthanum-doped copper oxide: novel heterocyclic sea sponge morphology for the efficient detection of dopamine.

Herein, we synthesized lanthanum (La)-doped sea sponge-shaped copper oxide (CuO) nanoparticles and wrapped them with novel O-, N- and S-rich (2Z,5Z)-3-acetyl-2-((3,4-dimethylphenyl)imino)-5-(2-oxoindolin-3-ylidene)thiazolidin-4-one (La@CuO-DMT). The shape and composition of the designed materials were confirmed by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and Raman spectroscopy. The graphitic pencil electrode (GPE) fabricated using La@CuO-DMT showed excellent sensing efficacy against dopamine (DA) with good selectivity, reproducibility and ideal stability. The unique morphology and massive surface defects by La@CuO offer good accessibility to DA and enhance smooth and robust channeling of electrons at the electrode-electrolyte interface. Consequently, these properties resulted in improved reaction kinetics and robust DA oxidation with an amplified faradaic response. Meanwhile, O-, N-, and S-enriched carbon support, i.e. DMT, inhibited the leaching of electrode matrixes, resulting in a superior detection limit of 423 nm and an improved sensitivity of 13.9 µA µM-1 cm-2 in the linear range of 10 µM to 1500 µM. Additionally, the developed sensing interface was successfully employed to analyze DA from tear samples with excellent percentage recoveries. We expect that such engineered morphology-based nanoparticles with a O-, N-, and S-rich C support will facilitate the development of DA sensors for in vitro screening of rarely studied tear samples with good sensitivity and selectivity.

Insight into prognostics, diagnostics, and management strategies for SARS CoV-2.

The foremost challenge in countering infectious diseases is the shortage of effective therapeutics. The emergence of coronavirus disease (COVID-19) outbreak has posed a great menace to the public health system globally, prompting unprecedented endeavors to contain the virus. Many countries have organized research programs for therapeutics and management development. However, the longstanding process has forced authorities to implement widespread infrastructures for detailed prognostic and diagnostics study of severe acute respiratory syndrome (SARS CoV-2). This review discussed nearly all the globally developed diagnostic methodologies reported for SARS CoV-2 detection. We have highlighted in detail the approaches for evaluating COVID-19 biomarkers along with the most employed nucleic acid- and protein-based detection methodologies and the causes of their severe downfall and rejection. As the variable variants of SARS CoV-2 came into the picture, we captured the breadth of newly integrated digital sensing prototypes comprised of plasmonic and field-effect transistor-based sensors along with commercially available food and drug administration (FDA) approved detection kits. However, more efforts are required to exploit the available resources to manufacture cheap and robust diagnostic methodologies. Likewise, the visualization and characterization tools along with the current challenges associated with waste-water surveillance, food security, contact tracing, and their role during this intense period of the pandemic have also been discussed. We expect that the integrated data will be supportive and aid in the evaluation of sensing technologies not only in current but also future pandemics.

Nickel -doped iron oxide nanoparticle-conjugated porphyrin interface (porphyrin/Fe2O3@Ni) for the non-enzymatic detection of dopamine from lacrimal fluid.

Herein, we synthesized nickel (Ni)-doped iron oxide nanoparticles (Fe2O3). The presence of the dopant afforded anchoring sites for the porphyrinic hetero cavity of 5,10,15,20-(tetra-4-carboxyphenyl)porphyrin to produce the porphyrin/Fe2O3@Ni composite. The crystalline structure and morphology of porphyrin/Fe2O3@Ni were assessed using various tools including Fourier transform spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction (XRD) and Raman spectroscopy. Porphyrin/Fe2O3@Ni has proven to be an excellent dopamine (DA) probe material with good selectivity, reproducibility, stability and reliability owing to its clever morphology, which induces numerous active sites along with good active surface area. It consequently provides good accessibility to DA and allows for the smooth tunneling of electrons between the analyte and sensing interface. Meanwhile, the porphyrin molecules provide good carbon-based resilient support, inhibit the leaching of the electrode matrix and enhance electron shuttling, resulting in the robust oxidation of DA with amplified transduction signals. The designed porphyrin/Fe2O3@Ni interface showed a low detection limit (1.2 nm) with good sensitivity (1.2 nM) in the linear bounds of 10 µM to 3500 µM. Additionally, the interface was employed successfully to analyze DA from lacrimal fluid with good percentage recoveries (99.8% to 100.1%). We anticipate that such a design will simplify the in vitro screening of DA in rarely studied tear samples with sensitivity and selectivity.

Fabrication of ionic liquid stabilized MXene interface for electrochemical dopamine detection.

Development of MXene (Ti3C2Cl2)-based sensing platforms by exploiting their inherent active electrochemistry is highly challenging due to their characteristic poor stability in air and water. Herein, we report a cost-effective methodology to deposit MXene on a conductive graphitic pencil electrode (GPE). MXenes can provide active surface area due to their clever morphology of accordion-like sheets; however, the disposition to stack together limits their potential applications. A task-specific ionic liquid (1-methyl imidazolium acetate) is utilized as a multiplex host material to engineer MXene interface via π-π interactions as well as to act as a selective binding site for biomolecules. The resulting IL-MXene/GPE interface proved to be a highly stable interface owing to good interactions between MXene and IL that inhibited electrode leaching and boosted electron transfer at the electrode-electrolyte interface. It resulted in robust dopamine (DA) oxidation with amplified faradaic response and enhanced sensitivity (9.61 µA µM-1 cm-2) for DA detection. This fabricated sensor demonstrated large linear range (10 µM - 2000 µM), low detection limit (702 nM), high reproducibility, and good selectivity. We anticipate that such platform will pave the way for the development of stable and economically viable MXene-based sensors without sacrificing their inherent properties. Scheme 1 Schematic illustration of the IL-MXene/GPE fabrication and oxidative process towards non-enzymatic dopamine sensor.

Perylene diimide/MXene-modified graphitic pencil electrode-based electrochemical sensor for dopamine detection.

The synthesis of novel architecture comprising perylene diimide (PDI)-MXene (Ti3C2TX)-integrated graphitic pencil electrode for electrochemical detection of dopamine (DA) is reported. The good electron passage between PDI-MXene resulted in an unprecedented nano-adduct bearing enhanced electrocatalytic activity with low-energy electronic transitions. The anionic groups of PDI corroborated enhanced active surface area for selective binding and robust oxidation of DA, thereby decreasing the applied potential. Meanwhile, the MXene layers acted as functional conducive support for PDI absorption via strong H-bonding. The considerable conductivity of MXene enhanced electron transportation thus increasing the sensitivity of sensing interface. The inclusively engineered nano-adduct resulted in robust DA oxidation with ultra-sensitivity (38.1 µAµM-1cm-2), and low detection limit (240 nM) at very low oxidation potential (-0.135 V). Moreover, it selectively signaled DA in the presence of physiological interferents with wide linearity (100-1000 µM). The developed transducing interface performed well in human serum samples with RSD (0.1 to 0.4%) and recovery (98.6 to 100.2%) corroborating the viability of the practical implementation of this integrated system. Graphical abstract Schematic illustration of the oxidative process involved on constructed sensing interface for the development of a non-enzymatic dopamine sensor.

Copper oxide integrated perylene diimide self-assembled graphitic pencil for robust non-enzymatic dopamine detection.

Exploring a robust, extremely sensitive, cost-effective and reliable assay platform for the precise analysis of dopamine (DA) has become a big challenge predominantly at the clinical level. To participate in this quest, herein, we fabricated a perylene diimide (PDI) self-assembled graphitic surface of the graphitic pencil electrode (GPE) anchored copper oxide (CuO). The self-assembled N-rich PDI led to the fast movement of ions by decreasing the bandgap and improved the electron transport kinetics with more exposed catalytic active sites, thus resulting in the robust electrochemical sensing of DA. The designed sensor exhibited good sensitivity (4 µM-1 cm-2), high structural stability, repeatability and excellent reproducibility with an RSD value of 2.9%. Moreover, the developed system showed a wide linear range (5 µM to 500 µM) and reliable selectivity even in the presence of co-existing interferants, such as ascorbic acid and uric acid. The fabricated nanohybrid was eventually employed to analyze DA in spiked physiological fluids and provided satisfactory recoveries. The designed PDI-CuO based interface also showed a very low detection limit of 6 nM (S/N = 3), consequently confirming its suitability for clinical and biological applications.