RESUMO
Acute generalized exanthematous pustulosis is a severe adverse skin reaction, usually caused by drugs, but in rare cases it can be associated with infections. Several cases related to COVID-19 have been reported, however, almost all were drug-related. Here we report a case of acute generalized exanthematous pustulosis associated with COVID-19 in a previously healthy 64-year-old woman, with no culprit drugs.
Assuntos
Pustulose Exantematosa Aguda Generalizada , COVID-19 , Humanos , Pustulose Exantematosa Aguda Generalizada/etiologia , Pustulose Exantematosa Aguda Generalizada/patologia , Pustulose Exantematosa Aguda Generalizada/diagnóstico , Feminino , Pessoa de Meia-Idade , COVID-19/complicações , SARS-CoV-2Assuntos
Anticorpos Monoclonais Humanizados , Dermatite Atópica , Falha de Tratamento , Humanos , Dermatite Atópica/tratamento farmacológico , Anticorpos Monoclonais Humanizados/uso terapêutico , Feminino , Masculino , Adulto , Pessoa de Meia-Idade , Fármacos Dermatológicos/uso terapêutico , Anticorpos Monoclonais/uso terapêuticoAssuntos
Fármacos Dermatológicos , Pitiríase Rubra Pilar , Ustekinumab , Humanos , Pitiríase Rubra Pilar/tratamento farmacológico , Pitiríase Rubra Pilar/patologia , Ustekinumab/uso terapêutico , Fármacos Dermatológicos/uso terapêutico , Resultado do Tratamento , Vacinas contra COVID-19/efeitos adversos , Masculino , Feminino , COVID-19/prevenção & controle , Pessoa de Meia-IdadeRESUMO
BACKGROUND: Hidradenocarcinoma is a rare malignant sweat gland tumour, characterized by a slow but aggressive course, with high rates of local recurrence and metastasis. Due to its rarity, histological criteria and therapeutic guidelines are poorly defined, posing a major challenge for clinicians and pathologists. OBJECTIVES: To present two new cases of metastatic hidradenocarcinoma as well as a review of the literature. MATERIALS & METHODS: We describe two case studies and a review of the literature based on a search using the MEDLINE (PubMed) electronic database. RESULTS: The first patient was a 61-year-old woman with a perimamillary hidradenocarcinoma that arose from the malignant transformation of a benign childhood lesion and developed regional lymph node metastases after wide excision and adjuvant radiotherapy. The second patient was a 63-year-old man who developed cutaneous and renal metastases several years after the complete excision of a lumbar hidradenocarcinoma. As far as we can ascertain, kidney metastasis from hidradenocarcinoma has not previously been described. CONCLUSION: Most authors recommend wide excision as the treatment of choice for hidradenocarcinoma, however, optimal adjuvant therapy remains to be determined. Our cases add to the limited knowledge available, but high-quality studies to find new effective treatments are needed.
Assuntos
Carcinoma de Apêndice Cutâneo , Neoplasias Renais , Neoplasias Cutâneas , Neoplasias das Glândulas Sudoríparas , Masculino , Feminino , Humanos , Criança , Pessoa de Meia-Idade , Neoplasias das Glândulas Sudoríparas/cirurgia , Terapia Combinada , Bases de Dados FactuaisRESUMO
An otherwise healthy 47-year-old woman presented with confluent pustular lesions on the scalp for 5 months and asymptomatic pustular lesions on the trunk and extremities for 2 weeks. She did not have systemic clinical manifestations and was treated with oral antifungals and antibiotics (amoxicillin, and clavulanic acid and flucloxacillin), with no effect. The lesions were unrelated to her menstrual cycle, and she had no history of dermatosis, including acne, psoriasis, or folliculitis. (SKINmed. 2022;20:466-468).
Assuntos
Acne Vulgar , Foliculite , Feminino , Humanos , Pessoa de Meia-Idade , Metotrexato , Couro Cabeludo/patologia , Foliculite/patologia , Antibacterianos , Acne Vulgar/patologiaAssuntos
Neoplasias dos Genitais Masculinos , Anormalidades da Pele , Pré-Escolar , Humanos , Masculino , EscrotoRESUMO
Cutaneous metastasis are uncommon and account for only 2% of all skin cancers, but are extremely rare in hypopharyngeal carcinomas. Although often associated with advanced cancer, cutaneous metastasis can be the first indication of relapse or treatment failure. Additionally, the clinical presentation is widely variable, which can make an early diagnosis difficult. New skin lesions should be evaluated in cancer patients to rule out metastases. Herein, we present a patient with an unusual cutaneous metastasis as the first sign of recurrence of a hypopharyngeal carcinoma.