Assuntos
Fármacos Dermatológicos/uso terapêutico , Linfoma Cutâneo de Células T , Terapia PUVA/métodos , Radioterapia/métodos , Neoplasias Cutâneas , Pele/patologia , Idoso , Antígenos de Diferenciação de Linfócitos T/análise , Atrofia , Diagnóstico Diferencial , Gerenciamento Clínico , Humanos , Linfoma Cutâneo de Células T/diagnóstico , Linfoma Cutâneo de Células T/imunologia , Linfoma Cutâneo de Células T/patologia , Linfoma Cutâneo de Células T/terapia , Masculino , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/imunologia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/terapiaRESUMO
Shiitake mushroom-induced toxicoderma, or shiitake dermatitis, is a widely recognized phenomenon in Japan, China, and Korea but only recently has been reported outside of Asia. Affected individuals develop a characteristic pattern of whiplike, linear, erythematous wheals within 1 to 2 days after consumption of raw or cooked shiitake mushrooms. Lentinan, a polysaccharide component of shiitake mushrooms with antitumor properties, is thought to instigate a toxic reaction, resulting in the appearance of a rash. Shiitake dermatitis is self-limited and typically resolves within days to weeks of its appearance.
Assuntos
Dermatite/etiologia , Intoxicação Alimentar por Cogumelos/complicações , Cogumelos Shiitake , Dermatite/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Intoxicação Alimentar por Cogumelos/patologia , Remissão EspontâneaAssuntos
Líquen Escleroso e Atrófico/diagnóstico , Esclerodermia Localizada/diagnóstico , Adulto , Antialérgicos/uso terapêutico , Dorso , Biópsia , Cetirizina/uso terapêutico , Humanos , Líquen Escleroso e Atrófico/patologia , Masculino , Esclerodermia Localizada/patologia , Urticária/tratamento farmacológicoAssuntos
Vesícula/diagnóstico , Líquen Plano/diagnóstico , Membrana Basal/patologia , Vesícula/tratamento farmacológico , Vesícula/patologia , Complemento C3/metabolismo , Dermatite/diagnóstico , Dermatite/patologia , Fármacos Dermatológicos/uso terapêutico , Eosinofilia/diagnóstico , Feminino , Humanos , Imunoglobulina G/metabolismo , Líquen Plano/tratamento farmacológico , Líquen Plano/patologia , Pessoa de Meia-Idade , Transtornos da Pigmentação/diagnóstico , Transtornos da Pigmentação/patologia , Prurido/diagnóstico , Prurido/patologia , Pele/patologia , Resultado do TratamentoRESUMO
Cutaneous T-cell lymphomas most commonly have a CD4(+) memory T-cell phenotype with relatively indolent course, but may in rare cases present with a CD8(+) cytotoxic phenotype exhibiting strikingly more aggressive clinical behavior. We present two cases of the clinically aggressive subtype of primary cutaneous epidermotropic CD8(+) cutaneous T-cell lymphoma and review the current literature, clinical behavior, and recommendations for treatment distinct from that of more common CD4(+) variants of cutaneous T-cell lymphoma.
Assuntos
Linfócitos T CD8-Positivos/imunologia , Linfoma Cutâneo de Células T/imunologia , Neoplasias Cutâneas/imunologia , Idoso , Idoso de 80 Anos ou mais , Bexaroteno , Terapia Combinada , Humanos , Linfoma Cutâneo de Células T/patologia , Linfoma Cutâneo de Células T/terapia , Masculino , Pele/imunologia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/terapia , Tetra-Hidronaftalenos/uso terapêuticoRESUMO
BACKGROUND: Endoscopic ultrasound guided fine needle aspiration biopsy (EUS-FNA) has proven to be an effective diagnostic modality for the detection and staging of pancreatic malignancies. In recent years EUS-FNA has also been used to diagnose lesions of non-pancreatic sites such as structures in close proximity to the gut wall within the mediastinum, abdomen, pelvis and retro-peritoneum. AIMS: To evaluate experience with EUS-FNA of non-pancreatic sites at a large university medical centre. METHODS: The study cohort included 234 patients who underwent EUS-FNA of 246 lesions in non-pancreatic sites (122 peri-pancreatic and coeliac lymph nodes; 9 peri-pancreatic masses; other sites: mediastinum 12, gastric 25, liver 27, oesophagus 17, duodenum/colon/rectum 15, retro-peritoneum 8, lung 7, miscellaneous 4). RESULTS: The cytology diagnoses were classified as non-neoplastic/reactive in 82 (33%), atypical/suspicious for malignancy in 25 (10%), malignant in 86 (35%) and non-diagnostic in 53 (22%) cases. Surgical pathology follow-up was available in 75 (31%) cases. Excluding the non-diagnostic cases there were 7 false negative and 3 false positive cases. The sensitivity, specificity and positive predictive value of EUS-FNA in the diagnosis of lesions of non-pancreatic sites was 92%, 98% and 97%, respectively. CONCLUSIONS: EUS-FNA can be effectively used as a diagnostic modality in the diagnosis of lesions from non-pancreatic sites.