Effect of Preparation Based on Trametes Pubescens Xylotroph Fungi on Lipid Peroxidation in the Blood of Experimental Animals under Conditions of Dark Stress.

Using the model of dark stress caused by animal maintenance at dimmed light we showed that Trametin (product obtained during liquid-phase culturing of Trametes pubescens xylotroph fungi) effectively prevented oxidative stress under conditions of light deprivation. The preparation increased the level of unsaturation of lipids, reduced the concentration of primary and end-products of LPO, and increases both the integral parameter of the antioxidant defense system (total antioxidant activity) and its components (activity of superoxide dismutase and reduced glutathione).

[Functional state of the lower urinary tract in children with enuresis]. / Funktsional'noe sostoianie nizhnikh mochevykh putei u detei s énurezom.

Basing on rich statistical materials, the authors studied functional state of the lower urinary tracts in children and adolescents with enuresis. A noticeable reservoir dysfunction of the bladder was found in the probands while evacuatory function did not differ much from healthy controls.

[The entry portals and routes of Yersinia pseudotuberculosis penetration into the warm-blooded organism]. / O vkhodnykh vorotakh i putiakh proniknoveniia Yersinia pseudotuberculosis v teplokrovnyi organizm.

This work presents data indicating that Y. pseudotuberculosis population, cultivated at lower temperature (6-8 degrees C), has a high potential of cellular and tissue invasiveness. Pseudotuberculosis has been experimentally shown to start as generalized infection due to the rapid (during 10-15 minutes) penetration of the infective agent through the epithelium of the mouth cavity, the small intestine, the urinary bladder, conjunctiva, pulmonary alveoli and vascular walls into the blood and then into internal organs. The data, obtained in this study, on the penetration of Y. pseudotuberculosis through any mucous surfaces in different species of warm-blooded animals are indicative, to a considerable extent, of the fact that this process occurs due to the action of nonspecific mechanisms.

[Chemotaxis of Yersinia pseudotuberculosis as a mechanism in its search for target tissues of the host organism]. / Khemotaksis Yersinia pseudotuberculosis kak mekhanizm poiska tkanevykh mishenei organizma khoziaina.

Y. pseudotuberculosis cells grown at biologically low temperature have been shown capable of chemotaxis with respect to carbohydrates and amino acids. During cultivation at 36-37 degrees C Y. pseudotuberculosis cells retain this property for 10-15 hours and then lose it. The mechanism of chemotaxis makes it possible for Y. pseudotuberculosis to "find" human and animal tissues and can facilitate the realization of the pathogenicity potential of these bacteria. When administered orally to mice motile bacteria, i. e. those grown at 6-8 degrees C, have been more virulent for the animals than nonmotile ones cultivated at 36-37 degrees C.

[Pathomorphology of the intestine and regional lymphatic system in pseudotuberculosis]. / Patomorfologiia kishechnika i regionarnogo limfaticheskogo apparata pri psevdotuberkuleze.

Available are data obtained at light and electron microscopy of operative specimens from patients with abdominal pseudotuberculosis and animals challenged orally with Yersinia pseudotuberculosis. The authors are the first to outline detailed characteristics of the intestinal and regional lymph node lesion arising in response to the infection and reflecting growing resistance to it. These features of pathological process involve marked tissue eosinophilia, necrosis due to phagocytes rexis, and granulomatosis suggesting a pronounced role in the pathogenesis of the body allergization in the course of infection. It is proposed to consider pseudotuberculosis-related changes in lymph nodes as lymphoblastic (early affection) and granulomatous-necrotic (advanced infection) lymphadenitis. The evidence obtained can promote differential diagnosis of pseudotuberculosis.