Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade Obesity.

Objective: Obesity is one of the modifiable risk factors for dementia. Insulin resistance, the abundance of advanced glycated end-products, and inflammation are some of the mechanisms associated with the lower cognitive performance observed in obesity. This study aims to evaluate the cognitive function of subjects with distinct degrees of obesity, comparing class I and II obesity (OBI/II) to class III obesity (OBIII), and to investigate metabolic markers that can distinguish OBIII from OBI/II. Study Design. This is a cross-sectional study, in which 45 females with BMI varying from 32.8 to 51.9 kg/m2 completed a set of 4 cognitive tests (verbal paired-associate test, stroop color, digit span, and Toulouse-Pieron cancellation test) and their plasma metabolites, enzymes, and hormones related to glycemia, dyslipidemia, and liver function, as well as the biomarkers of iron status, were concomitantly analyzed. Results: OBIII showed lower scores in the verbal paired-associate test compared to OBI/II. In other cognitive tests, both groups showed similar performance. OBIII presented a lower iron status compared to OBI/II based on total iron binding capacity, degree of transferrin saturation, hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin. The levels of indicators for glycemia, liver function, and lipid metabolism were similar in both groups. Analysis of plasma metabolites showed that OBIII had lower levels of pyroglutamic acid, myoinositol, and aspartic acid and higher levels of D-ribose than OBI/II. Conclusion: Iron is an essential micronutrient for several metabolic pathways. Thus, iron dyshomeostasis observed in severe obesity may aggravate the cognitive impairment by altering metabolic homeostasis and enhancing oxidative stress. These findings can contribute to searching for biomarkers that indicate cognitive performance in the population with obesity.

Aerobic physical exercise improved the cognitive function of elderly males but did not modify their blood homocysteine levels.

BACKGROUND: Physical exercise influences homocysteine (Hcy) concentrations, cognitive function and the metabolic profile. The purpose of this study was to investigate the influence of regular physical exercise on Hcy levels, the metabolic profile and cognitive function in healthy elderly males before and after an endurance exercise program. METHODS: Forty-five healthy and sedentary volunteers were randomized into 2 groups: (1) a control group asked not to change their normal everyday activities and not to start any regular physical exercise program and (2) an experimental group trained at a heart rate intensity corresponding to ventilatory threshold 1 (VT-1) for 60 min/day 3 times weekly on alternate days for 6 months using a cycle ergometer. All volunteers underwent cognitive evaluations, blood sample analyses and ergospirometric assessments. RESULTS: A significant improvement in cognitive function was observed in the experimental group compared with the control group (p < 0.05). No significant changes in Hcy levels were observed in the experimental group (p > 0.05), but there was a significant increase in peak oxygen consumption and workload at VT-1 as well as a significant improvement in cholesterol, triglycerides, HDL, glucose, alkaline phosphatase, urea, T3, T4 and prostate-specific antigen compared with the control group (p < 0.05). CONCLUSION: The data suggest that a physical exercise program does not reduce Hcy levels in healthy elderly males, although it improves the cardiovascular and metabolic profile as well as cognitive function.

Negative addiction to exercise: are there differences between genders?

INTRODUCTION: Regular physical exercise has numerous benefits. However, there is a subset of the exercising population who may develop a compulsion to exercise excessively and who may, as a consequence, display physiological and psychological changes that have a direct influence on their quality of life. OBJECTIVE: Our objective was to determine if there are differences between male and female athletes' scores on measures of negative addiction symptoms, quality of life, mood and sleep. METHODS: 144 female and 156 male athletes participated in this study by answering the following questionnaires: Negative Addiction Scale, Beck Depression Inventory, Trait Anxiety Inventory, Profile of Mood States, SF-36 Quality of Life, Pittsburgh Sleep Quality and Epworth Sleepiness Scale. RESULTS: Higher dedication to training sessions in the male group, and members of the female group with symptoms of negative addiction to exercise showed a lower score on vigor observed by the Profile of Mood States compared to the males in both situations. We also observed depression symptoms in both members of groups who had negative addiction symptoms when compared with their peers without symptoms, and these figures were even higher in females compared with the male group in the same situation. CONCLUSION: No differences were seen in the development of negative addiction exercise symptoms in males and females and there were no changes in the quality of life and mood of these athletes. Further studies of eating disorders associated with changes in body image perception could contribute to a better understanding of negative addiction to exercise.

Negative addiction to exercise: are there differences between genders?

INTRODUCTION: Regular physical exercise has numerous benefits. However, there is a subset of the exercising population who may develop a compulsion to exercise excessively and who may, as a consequence, display physiological and psychological changes that have a direct influence on their quality of life. OBJECTIVE: Our objective was to determine if there are differences between male and female athletes' scores on measures of negative addiction symptoms, quality of life, mood and sleep. METHODS: 144 female and 156 male athletes participated in this study by answering the following questionnaires: Negative Addiction Scale, Beck Depression Inventory, Trait Anxiety Inventory, Profile of Mood States, SF-36 Quality of Life, Pittsburgh Sleep Quality and Epworth Sleepiness Scale. RESULTS: Higher dedication to training sessions in the male group, and members of the female group with symptoms of negative addiction to exercise showed a lower score on vigor observed by the Profile of Mood States compared to the males in both situations. We also observed depression symptoms in both members of groups who had negative addiction symptoms when compared with their peers without symptoms, and these figures were even higher in females compared with the male group in the same situation. CONCLUSION: No differences were seen in the development of negative addiction exercise symptoms in males and females and there were no changes in the quality of life and mood of these athletes. Further studies of eating disorders associated with changes in body image perception could contribute to a better understanding of negative addiction to exercise.

Mood, anxiety, and serum IGF-1 in elderly men given 24 weeks of high resistance exercise.

As aging advances, changes in mood and anxiety may imply greater risk of mood disorders, particularly anxiety and depression. Resistance exercise reduces anxiety and lessens risk of depression in the elderly, but little is known of the mechanisms involved. It was hypothesized that the human growth factor (IGF-1) may improve mood and anxiety in elderly participants given resistance training. 43 elderly men ages 65 to 75 years were randomly assigned to two groups, Control (n = 23) and high resistance Exercise (n = 20). After 24 wk., the Exercise group showed improved muscular strength and higher IGF-1 serum levels than the Con-trol group, as indicated by mean scores on a visual analogue mood scale and the State-Trait Anxiety Inventory. Intensive resistance training was efficacious in improving mood, anxiety, and IGF-1 serum concentration in elderly individuals free of clinical mood disorders.

Dependência de exercício físico: humor, qualidade de vida em atletas amadores e profissionais / Physical exercise dependence: mood, quality of life in amateur and professional athletes

O objetivo do presente estudo foi verificar se existem diferenças nos escores de Dependência de Exercício (DE), escores de humor e qualidade de vida em atletas profissionais e amadores de modalidade esportivas coletivas e individuais. MÉTODOS: Participaram deste estudo 116 atletas praticantes de modalidades esportivas coletivas (n = 60, sendo 20 profissionais e 40 amadores) e individuais (n = 56, sendo 16 profissionais e 40 amadores) do gênero masculino. As médias (± desvio-padrão) da idade, estatura, massa corporal e índice de massa corpórea (IMC) foram: 22,13 ± 6,16 anos; 1,77 ± 0,10cm; 72,76 ± 10,04kg; e 23,10 ± 2,04kg/m², respectivamente. Os atletas responderam aos seguintes questionários: Escala de Dependência de Exercício (EDE), Inventário Beck de Depressão, Idate Traço e Estado de Ansiedade, Questionário POMS de perfil de humor, Questionário SF-36 de Qualidade de Vida, em um dia de folga dentro da periodização normal de treinamento, caracterizando o estudo como transversal. O trabalho foi aprovado pelo Comitê de Ética em Pesquisa da Unifesp (# 0616/06). RESULTADOS: Atletas amadores e profissionais apresentaram escores similares de DE, mas quando considerados os tipos de modalidade, os amadores praticantes de modalidades coletivas apresentam maiores escores, o que se inverte quando considerados atletas profissionais. Em relação aos resultados de humor, atletas profissionais apresentaram mais qualidade de vida e menores escores de humor. CONCLUSÃO: Atletas amadores e profissionais praticantes de modalidades esportivas coletivas e individuais respondem diferentemente à DE; o tipo de modalidade e seu envolvimento social e competitivo parecem ser o grande determinante. Além disso, pode-se concluir que atletas profissionais de modalidades coletivas apresentam melhor perfil de humor e qualidade de vida, tanto quando comparados com profissionais de modalidades individuais, quando com atletas amadores praticantes de modalidades coletivas...

The purpose of this study was to verify if there are differences between exercise dependence (ED), mood and quality of life scores in professional and amateur athletes of individual and collective sport modalities. METHODS: 116 male athletes of collective sport modalities (n=60, 20 professionals and 40 amateurs) and individual sport modalities (n=56, 16 professionals and 40 amateurs) participated in this study. Age, height, weight, BMI mean (± standard-deviation) were: 22.13 ± 6.16 years; 1.77 ± 0.10 cm; 72.76 ± 10.04 kg and 23.10 ± 2.04 kg/m², respectively. The athletes answered the following questionnaires: Exercise Dependence scale (EDE), Beck Depression Inventory, Trait and State of Anxiety - IDATE, POMS - profile of mood states, SF-36 Questionnaire of Quality of Life. The study was approved by the Ethics in Research Committee of UNIFESP (#0616/06). RESULTS: Amateur and professional athletes presented similar scores of ED, but when the kind of modality was considered, the amateurs of collective modalities presented higher scores than professional athletes. CONCLUSION: Amateur and professional athletes of collective and individual sport modalities answered differently to ED, and the sports modality and competitive and social involvement could be determinant. Moreover, it is possible to conclude that professional athletes of collective sports present better profile of mood and quality of life when compared with professional athletes of individual sports when compared with amateur athletes from collective or individual sport modalities.

Privação de sono e exercício físico / Sleep deprivation and exercise

A privação do sono é a remoção ou supressão parcial do sono, e esta condição pode causar diversas alterações: endócrinas, metabólicas, físicas, cognitivas, neurais e modificações na arquitetura do sono, que em conjunto comprometem a saúde e a qualidade de vida do sujeito nestas condições. Já o exercício físico praticado regularmente promove benefícios como melhora do aparato cardiovascular, respiratório, endócrino, muscular e humoral, além disso, pode melhorar a qualidade do sono. Entretanto, a associação desses dois parâmetros não tem sido bem explorada, em parte pela dificuldade conseguir voluntários que se submetam a essa condição principalmente sem nenhum tipo de compensação financeira. A maioria dos estudos que investigaram o binômio exercício físico e privação de sono focou os efeitos no desempenho aeróbio. Embora ainda haja controvérsias, os estudos apontam para pequena ou nenhuma alteração desse parâmetro quando as duas situações se fazem presentes. Em relação à potência anaeróbia e força não tem sido encontrados alterações significativas, mas para eventos prolongados, parece haver uma interação entre a privação de sono e o exercício físico, o que sugere um mecanismo de proteção. Entretanto, é importante considerar que uma das alterações mais importantes causadas pela privação do sono é o aumento na percepção subjetiva, que por si só já representa um fator para diminuição e comprometimento do desempenho físico e pode representar um elemento de "mascaramento" dos efeitos deletérios da privação. Assim, o objetivo da presente revisão é o de discutir os diferentes aspectos da relação entre o exercício físico e a privação de sono, evidenciando seus efeitos e reflexos no desempenho físico.

Sleep deprivation can be defined as total or partial suppress of sleep and is associated with alterations in endocrine, metabolic, physical, cognitive functions and modifications of the sleep patterns that compromise health and quality of life. Physical exercise is associated with improvement of cardiovascular, respiratory, muscular, endocrine and nervous system, and a better sleep quality. However, the association of these two conditions is unclear, partly due to the difficulty to obtain volunteers to participate in this type of protocol with no financial compensation. The majority of the studies which investigate the association between physical exercises and sleep deprivation focus on aerobic performance and verify little or no effect of this parameter. Concerning anaerobic power and strength, significant alterations have not been found; however, for prolonged events there may be an interaction between these two factors, which suggests a protection mechanism. Nevertheless, it is important to consider that one of the main alterations caused by sleep deprivation the increase of the subjective perception, which presents a factor to decrease and compromise the physical performance per se, and may represent a masking element of the deleterious effects of sleep deprivation. Thus, the aim of present review is to discuss the different aspects of relationship between physical exercise and sleep deprivation, showing their effects and consequences in physical performance.

Avaliação da composição corporal em adolescentes obesos: o uso de dois diferentes métodos / Body composition evaluation in obese adolescents: the use of two different methods

A pletismografia é um método rápido e fácil para determinação da composição corporal que utiliza a relação inversa entre pressão e volume. O objetivo do presente estudo foi o de comparar os valores obtidos com o método pletismografia com os valores observados com o DEXA em uma população de adolescentes obesos. Participaram da amostra 88 adolescentes pós-púberes de ambos os sexos, com idades entre 15 e 19 anos (17,01 ± 1,6) ingressantes de um programa de atividade física multidisciplinar. Os voluntários foram submetidos a uma avaliação da composição corporal em dias distintos dentro da mesma semana, pelo método de pletismografia e outra avaliação pelo método DEXA. Quando os métodos foram comparados, não se observaram diferenças significativas entre eles; além disso, foram observadas correlações significativas entre os parâmetros comuns dos dois métodos (massa magra, massa gorda (kg) e massa gorda ( por cento), r = 0,88 p < 0,05; r = 0,92 p < 0,05; r = 0,75 p < 0,05, respectivamente). Nossos dados sugerem que, para esta população específica, a pletismografia pode ser utilizada como um método de avaliação da composição corporal.

Efeitos do exercício físico e da atividade física na depressão e ansiedade em indivíduos idosos / Effects of the physical exercise and physial activity on the depression and anxiety in elderly

O presente estudo teve como objetivo verificar a influência do exercício físico e da atividade física nos aspectos psicológicos (índices indicativos para depressão e ansiedade) em idosos. Para tanto, foram selecionados 54 idosos saudáveis (66,85 ± 4,42 anos), de ambos os sexos, que foram subdivididos em 3 grupos: Grupo A – controle (indivíduos sedentários), n=18; Grupo B – grupo de desportistas (indivíduos sedentários que passaram a praticar exercícios físicos regularmente), n=18; Grupo C – grupo de lazer (indivíduos que participam de programas de atividade física não sistematizada) n=18. Os voluntários foram submetidos a uma avaliação inicial, na qual foram aplicados questionários que medem escores indicativos de depressão (Inventário Beck) e ansiedade (Idate Traço e Estado), também foram realizados um teste ergométrico com eletrocardiograma para estimativa do VO2 e exames laboratoriais. Após esta fase, os voluntários do Grupo B iniciaram um programa de exercício físico por um período de quatro meses sendo então reavaliados seguindo o mesmo protocolo inicial. Os resultados revelaram que o Grupo de desportistas obteve um índice satisfatório significativo de redução dos escores de depressão (Inventário Beck), passando de leve para normal, e em relação aos índices indicativos para ansiedade (Idate Traço e Estado) e os dados se demonstraram baixos em todos os grupos analisados. Os resultados sugerem que a prática regular de exercício físico orientado com parâmetros fisiológicos, pode contribuir na redução dos escores para depressão e ansiedade em indivíduos com mais de 60 anos.

The purpose of the present study was to verify the influence of physical exercise and physical activity over psychological aspects (indexes for depression and anxiety) in elders. For this study, 54 healthy elders (66,85 ± 4,42 age) of both sexes were randomly allocated in three groups: Group A – Control group (sedentary individuals) n=18, Group B – Sportsmanlike group (sedentary individuals who started to practice physical exercises regularly) n=18, and Group C – Leisure-time group (individuals who participate in programs of unsystematized physical activity) n=18. The volunteers were submitted to an initial evaluation, in which questionnaires that measure indicative scores of depression (Beck Depression Inventory) and anxiety (Idate Trait and State) were applied; an ergometric test with an electrocardiogram for the estimate of max VO2 and of laboratorial exams was also made. After this phase, Group B volunteers began a physical exercise program for 4 months, being reevaluated through the same initial protocol. The results revealed that the Sportsmanlike group obtained a significantly satisfactory index of decrease in depression scores (Beck Depression Inventory), going from light to normal, as well as in scores indicating anxiety (Idate Trait and State); also, data proved to be low in all analized groups. The results suggest that regular practice of physical exercise, oriented through physiological parameters, can help to decrease depression and anxiety scores in individuals above the age of 60.