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2.
Nature ; 567(7748): S7, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30894731
3.
Nature ; 567(7748): S12-S17, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30894736
4.
Nature ; 564(7735): S57, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30542195
5.
Exp Gerontol ; 113: 199-208, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30316811

RESUMO

BACKGROUND: Periodization is a systematic training calendar designed to provide variations in performance targeting, while maximizing results and reducing the potential for overtraining. When provided across multiple weeks, termed a mesocycle, it may also incorporate active recovery periods using specified drills designed to translate neuromuscular gains into targeted functional abilities. There are a number of models that can be used when applying periodization to resistance training (RT). Among the most common are the linear (LP) and daily fixed non-linear (NLP) models. It is currently unknown whether an optimal periodization strategy exists that will maximize benefits for older adults; therefore, we compared the impact of these two periodization models on neuromuscular and functional measures in a group of older persons living independently in the community. METHODS: Thirty-six older adults, 58-80 years of age, were randomly assigned to either a LP (n = 16; 69.3 ±â€¯4.6 y) or NLP (n = 14; 68.9 ±â€¯6.7 y) group. The LP group performed 12 weeks of training comprised of separate 4-week strength and power training cycles, each followed by a 2-week recovery period incorporating translational exercises. The NLP group performed the strength, power, and translational training on three separate days during the week. Neuromuscular testing included seated chest press and leg press strength and power tests, while physical function testing included the gallon jug shelf test, laundry transfer test, floor stand-up, chair-to-stand test, and 8 foot timed up-and-go. RESULTS: 3 (time) × 2 (sex) × 2 (group) repeated measures ANOVA revealed both periodization strategies were equally effective at inducing neuromuscular and functional improvements and that men generally produced more strength and power than women. CONCLUSIONS: Both LP and NLP can be used to improve strength, power, and functional performance in healthy untrained older adults when strength, power and functional training cycles are involved. Therefore, personal preference and variety should be considered when deciding which approach to use, provided high-speed power and translational recovery components are included.


Assuntos
Atividades Cotidianas , Envelhecimento/fisiologia , Força Muscular , Músculo Esquelético/fisiologia , Treinamento Resistido/métodos , Idoso , Composição Corporal , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Periodicidade
6.
Nature ; 561(7723): S10-S15, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-30232442
7.
Exp Gerontol ; 112: 76-87, 2018 10 02.
Artigo em Inglês | MEDLINE | ID: mdl-30223046

RESUMO

OBJECTIVES: Cognition, along with aerobic and muscular fitness, declines with age. Although research has shown that resistance and aerobic exercise may improve cognition, no consensus exists supporting the use of one approach over the other. The purpose of this study was to compare the effects of steady-state, moderate-intensity treadmill training (TM) and high-velocity circuit resistance training (HVCRT) on cognition, and to examine its relationships to aerobic fitness and neuromuscular power. METHODS: Thirty older adults were randomly assigned to one of three groups: HVCRT, TM, or control. Exercise groups attended training 3 days/wk for 12 weeks, following a 2 week adaptation period. The NIH Cognitive Toolbox was used to assess specific components of cognition and provided an overall fluid composite score (FCS). The walking response and inhibition test (WRIT) was specifically used to assess executive function (EF) and provided an accuracy (ACC), reaction time (RT) and global score (GS). Aerobic power (AP) and maximal neuromuscular power (MP) were measured pre- and post-intervention. Relationships between variables using baseline and mean change scores were assessed. RESULTS: Significant increases were seen from baseline in ACC (MD = 14.0, SE = 4.3, p = .01, d = 1.49), GS (MD = 25.6, SE = 8.0, p = .01, d = 1.16), and AP (MD = 1.4, SE = 0.6, p = .046, d = 0.31) for HVCRT. RT showed a trend toward a significant decrease (MD = -0.03, SE = 0.016, p = .068, d = 0.32) for HVCRT. No significant within-group differences were detected for TM or CONT. Significant correlations were seen at baseline between AP and FCS, as well as other cognitive domains; but none were detected among change scores. Although no significant correlation was evident between MP and FCS or GS, there was a trend toward higher MP values being associated with higher FCS and GS scores. CONCLUSIONS: Our results support the use of HVCRT over TM for improving cognition in older persons, although the precise mechanisms that underlie this association remain unclear.


Assuntos
Exercícios em Circuitos/métodos , Envelhecimento Cognitivo , Função Executiva , Aptidão Física , Treinamento Resistido/métodos , Idoso , Cognição , Teste de Esforço , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos
8.
Nature ; 558(7711): S18, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29950642
9.
Nature ; 558(7711): S1, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29950645
10.
Appl Physiol Nutr Metab ; 43(8): 822-832, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29539268

RESUMO

The presence of cardiometabolic syndrome (CMS) confers an increased risk for cardiovascular disease (CVD) and mortality and is associated with reduced health-related quality of life (HRQoL). Although the effects of exercise on biomarkers, HRQoL, and future risk have been studied, no study has measured the effects on all three components. The present study compared the effects of steady-state, moderate-intensity treadmill training (TM) and high-velocity circuit resistance training (HVCRT) on biological markers, HRQoL, and overall CVD risk in adults with CMS and CVD risk factors. Thirty participants (22 females, 8 males) were randomly assigned to 1 of 3 groups: HVCRT, TM, or control. Participants in the exercise groups attended training 3 days/week for a total of 12 weeks. Of the 30 participants who began the study, 24 (19 females, 5 males) were included in the final analysis. Primary outcome measures included CMS criteria, hemodynamic measures, Framingham Risk Score (FRS), and HRQoL. All variables were measured pre- and post-intervention. CMS z score significantly decreased for HVCRT (p = 0.03), while there were no significant changes for TM or control. FRS significantly decreased for HVCRT compared with TM (p = 0.03) and control (p = 0.03). Significant decreases in systolic (p < 0.01) and diastolic blood pressures (p < 0.01) for HVCRT accompanied significant increases from baseline in stroke volume (p = 0.03) and end-diastolic volume (p < 0.01). Systemic vascular resistance significantly decreased (p = 0.05) for HVCRT compared with control. Emotional well-being significantly improved following HVCRT and TM compared with control (p = 0.04; p = 0.03). HVCRT represents a novel training modality that improved factors in each of the 3 components assessed.


Assuntos
Envelhecimento , Hemodinâmica , Síndrome Metabólica/prevenção & controle , Qualidade de Vida , Treinamento Resistido/métodos , Caminhada , Fatores Etários , Idoso , Envelhecimento/sangue , Envelhecimento/psicologia , Biomarcadores/sangue , Pressão Sanguínea , Emoções , Tolerância ao Exercício , Feminino , Florida , Humanos , Masculino , Síndrome Metabólica/sangue , Síndrome Metabólica/fisiopatologia , Síndrome Metabólica/psicologia , Pessoa de Meia-Idade , Volume Sistólico , Fatores de Tempo , Resultado do Tratamento , Resistência Vascular
11.
Nature ; 555(7697): S49, 2018 03 22.
Artigo em Inglês | MEDLINE | ID: mdl-29565376
12.
Nature ; 555(7697): S49, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32034354
13.
J Fam Plann Reprod Health Care ; 39(3): 186-9, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23243152

RESUMO

OBJECTIVE: To follow a series of 100 women attending for fitting of the levonorgestrel-releasing intrauterine system (LNG IUS) registered at a single urban general practice serving the students of the local universities and higher education colleges. METHODS: This was a prospective observational study. A questionnaire was completed by the fitter in discussion with the patient at the time of attendance for IUS fitting. Follow up was by telephone at 6 weeks, 6 months and 9-12 months after fitting. RESULTS: The age range of women within the series was 18-38 years. 97 women were nulliparous. 37 women selected the IUS as their preferred method of contraception. 12 women chose the IUS primarily for non-contraceptive reasons. 75 women still had the IUS at 12 months' follow up with 11 lost to follow up at this point. No pregnancies or perforations were reported. CONCLUSIONS: The IUS is an acceptable form of contraception in young women, including nulliparous women, and should be offered alongside other methods as first line without restriction when offering contraceptive options to this age group.


Assuntos
Anticoncepcionais Femininos , Dispositivos Intrauterinos Medicados/estatística & dados numéricos , Levanogestrel , Estudantes/estatística & dados numéricos , Adolescente , Adulto , Feminino , Medicina Geral/estatística & dados numéricos , Humanos , Estudos Prospectivos , Reino Unido , Universidades , Adulto Jovem
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