RESUMO
Painting with heavy catalytic gas oil was followed by skin tumor development in 97 (84.3%) mice: benign lesions--21 and carcinoma--76 cases. Pathologic changes in the upper part of the digestive tract were found in 55 out of 106 mice (51.9%): precancerous lesions (leukoplakia, dysplasia and papilloma) in 54 cases and cancer in one animal. Frequency of development of papilloma in the cardia was 27 times that in the esophagus. Multicentric growth was typical of precancerous lesions. Papilloma of the cardia was found in one control animal. Resorptive as well as direct action of gas oil seem to have been the causative factors of the development of precancerous and neoplastic lesions of the upper part of the gastrointestinal tract. The agent found its way into the digestive tract as animals licked each other in the course of the experiments.
Assuntos
Neoplasias Esofágicas/induzido quimicamente , Petróleo/toxicidade , Lesões Pré-Cancerosas/induzido quimicamente , Absorção Cutânea/efeitos dos fármacos , Neoplasias Gástricas/induzido quimicamente , Administração Tópica , Animais , Cárdia/efeitos dos fármacos , Cárdia/patologia , Neoplasias Esofágicas/patologia , Esôfago/efeitos dos fármacos , Esôfago/patologia , Feminino , Leucoplasia/induzido quimicamente , Leucoplasia/patologia , Camundongos , Papiloma/induzido quimicamente , Papiloma/patologia , Lesões Pré-Cancerosas/patologia , Neoplasias Gástricas/patologia , Fatores de TempoRESUMO
The carcinogenic effect of treatment with heavy catalytic gasoil on the skin of 120 albino noninbred mice was studied. Skin tumors arose in 97 of 115 animals (84.3%) which survived until the appearance of the first papillomas. In 21 mice, tumors were benign while cancer developed in 76 animals. 116 visceral neoplasms were detected in 99 animals (93.4%). They were found in the upper part of digestive tract of 57, the hematopoietic and lymphatic tissues of 57 and in the lungs of two animals. The study established a high carcinogenicity of heavy catalytic gasoil matched by early appearance and multicentric growth of tumors as well as rapid generalization of the process.