Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis.

Clinical studies have shown that Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is associated with aggressive periodontitis and can potentially trigger or exacerbate rheumatoid arthritis (RA). However, the mechanism is poorly understood. Here, we show that systemic infection with A. actinomycetemcomitans triggers the progression of arthritis in mice anti-collagen antibody-induced arthritis (CAIA) model following IL-1ß secretion and cell infiltration in paws in a manner that is dependent on caspase-11-mediated inflammasome activation in macrophages. The administration of polymyxin B (PMB), chloroquine, and anti-CD11b antibody suppressed inflammasome activation in macrophages and arthritis in mice, suggesting that the recognition of lipopolysaccharide (LPS) in the cytosol after bacterial degradation by lysosomes and invasion via CD11b are needed to trigger arthritis following inflammasome activation in macrophages. These data reveal that the inhibition of caspase-11-mediated inflammasome activation potentiates aggravation of RA induced by infection with A. actinomycetemcomitans. This work highlights how RA can be progressed by inflammasome activation as a result of periodontitis-associated bacterial infection and discusses the mechanism of inflammasome activation in response to infection with A. actinomycetemcomitans.

Influence of scene aspect ratio and depth cues on verticality perception bias.

Perceiving verticality is crucial for accurate spatial orientation. Previous research has revealed that tilted scenes can bias verticality perception. Verticality perception bias can be represented as the sum of multiple periodic functions that play a role in the perception of visual orientation, where the specific factors affecting each periodicity remain uncertain. This study investigated the influence of the width and depth of an indoor scene on each periodic component of the bias. The participants were presented with an indoor scene showing a rectangular checkerboard room (Experiment 1), a rectangular aperture on the wall (Experiment 2), or a rectangular dotted room (Experiment 3), with various aspect ratios. The stimuli were presented with roll orientations ranging from 90° clockwise to 90° counterclockwise. The participants were asked to report their subjective visual vertical (SVV) perceptions. The contributions of 45°, 90°, and 180° periodicities to the SVV error were assessed by the weighted vector sum model. In Experiment 1, the periodic components of the SVV error increased with the aspect ratio. In Experiments 2 and 3, only the 90° component increased with the aspect ratio. These findings suggest that extended transverse surfaces may modulate the periodic components of verticality perception.

Revisiting the Deviation Effects of Irrelevant Sound on Serial and Nonserial Tasks.

Two types of disruptive effects of irrelevant sound on visual tasks have been reported: the changing-state effect and the deviation effect. The idea that the deviation effect, which arises from attentional capture, is independent of task requirements, whereas the changing-state effect is specific to tasks that require serial processing, has been examined by comparing tasks that do or do not require serial-order processing. While many previous studies used the missing-item task as the nonserial task, it is unclear whether other cognitive tasks lead to similar results regarding the different task specificity of both effects. Kattner et al. (Memory and Cognition, 2023) used the mental-arithmetic task as the nonserial task, and failed to demonstrate the deviation effect. However, there were several procedural factors that could account for the lack of deviation effect, such as differences in design and procedures (e.g., conducted online, intermixed conditions). In the present study, we aimed to investigate whether the deviation effect could be observed in both the serial-recall and mental-arithmetic tasks when these procedural factors were modified. We found strong evidence of the deviation effect in both the serial-recall and the mental-arithmetic tasks when stimulus presentation and experimental design were aligned with previous studies that demonstrated the deviation effect (e.g., conducted in-person, blockwise presentation of sound, etc.). The results support the idea that the deviation effect is not task-specific.

Blue-yellow combination enhances perceived motion in Rotating Snakes illusion.

The Rotating Snakes illusion is a visual illusion where a stationary image elicits a compelling sense of anomalous motion. There have been recurring albeit anecdotal claims that the perception of illusory motion is more salient when the image consists of patterns with the combination of blue and yellow; however, there is limited empirical evidence that supports those claims. In the present study, we aimed to assess whether the Rotating Snakes illusion is more salient in its blue-yellow variation, compared to red-green and greyscale variations when the luminance of corresponding elements within the patterns were equated. Using the cancellation method, we found that the velocity required to establish perceptual stationarity was indeed greater for the stimulus composed of patterns with a blue-yellow combination than the other two variants. Our findings provide, for the first time, empirical evidence that the presence of colour affects the magnitude of illusion in the Rotating Snakes illusion.

Safety and outcome of three-dimensional transoral videolaryngoscopic surgery.

BACKGROUND: Transoral videolaryngoscopic surgery (TOVS) is widely used in Japan, and conventional two-dimensional (2D) endoscopic methods have been established. Three-dimensional (3D) endoscopic surgery offers superior distance perception because it provides stereoscopic views. Recently, we have developed 3D endoscopy for TOVS (3D TOVS). METHODS: This study included 46 patients with pharyngeal cancer who underwent 3D TOVS. The perioperative complications and survival curves were retrospectively analyzed. RESULTS: One patient with oropharyngeal cancer who underwent neck dissection and transoral resection simultaneously experienced postoperative hemorrhage of the neck. Another patient with oropharyngeal cancer underwent hemostasis for postoperative pharyngeal hemorrhage. There was one case of aspiration pneumonia. One patient developed cervical lymph node recurrence; however, there was no local recurrence or primary mortality. The 2-year overall survival, disease-specific survival, local control rates, locoregional control rate, and invasive disease-free survival were 90.9%, 100%, 100%, 97.4%, and 79.9%, respectively. CONCLUSIONS: Three-dimensional endoscopy can be safely applied to TOVS.