RESUMO
Thiazolyl peptide antibiotics, nocathiacin I, II and III, were identified in a culture of Nocardia sp. WW-12651 (ATCC 202099). They exhibit potent in vitro activity (ng/ml) against a wide spectrum of gram-positive bacteria, including multiple-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), multi-drug resistant Enterococcus faecium (MREF) and fully penicillin-resistant Streptococcus pneumoniae (PRSP), and demonstrate excellent in vivo efficacy in a systemic Staphylococcus aureus infection mice model.
Assuntos
Antibacterianos/isolamento & purificação , Bactérias Gram-Positivas/efeitos dos fármacos , Nocardia/química , Peptídeos , Animais , Antibacterianos/química , Antibacterianos/classificação , Antibacterianos/farmacologia , Resistência Microbiana a Medicamentos , Resistência a Múltiplos Medicamentos , Fermentação , Camundongos , Testes de Sensibilidade Microbiana , Estrutura Molecular , Nocardia/classificaçãoRESUMO
A new group of thiazolyl peptide antibiotics, the nocathiacins, was isolated from cultured broth of Nocardia sp. The major analogs nocathiacins I-III (1-3) were purified using silica gel and Sephadex LH-20 chromatography techniques. The structures of nocathiacins I-III were determined by spectroscopic (2D-NMR, MSn) methods, and share structural similarities to glycothiohexide-alpha (4).