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1.
Vet Comp Oncol ; 16(1): E1-E15, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29027350

RESUMO

Cytotoxic drugs encapsulated into liposomes were originally designed to increase the anticancer response, while minimizing off-target adverse effects. The first liposomal chemotherapeutic drug was approved for use in humans more than 20 years ago, and the first publication regarding its use in a canine cancer patient was published shortly thereafter. Regardless, no general application for liposomal cytotoxic drugs has been established in veterinary oncology till now. Due to the popularity of canines as experimental models for pharmacokinetic analyses and toxicity studies, multiple publications exist describing various liposomal drugs in healthy dogs. Also, some evidence for its use in veterinary cancer patients exists, especially in canine lymphoma, canine splenic hemangiosarcoma and feline soft tissue sarcoma, however, the results have not been overwhelming. Reasons for this may be related to inherent issues with the enhanced permeability and retention effect, the tumour phenomenon which liposomal drugs exploit. This effect seems very heterogeneously distributed in the tumour. Also, it is potentially not as ubiquitously occurring as once thought, and it may prove important to select patients for liposomal therapy on an individual, non-histology-oriented, basis. Concurrently, new developments with active-release modified liposomes in experimental models and humans will likely be relevant for veterinary patients as well, and holds the potential to improve the therapeutic response. It, however, does not resolve the other challenges that liposomal chemotherapy faces, and more work still needs to be done to determine which veterinary patients may benefit the most from liposomal chemotherapy.


Assuntos
Antineoplásicos/administração & dosagem , Lipossomos/uso terapêutico , Neoplasias/veterinária , Animais , Antineoplásicos/uso terapêutico , Doenças do Gato/tratamento farmacológico , Gatos , Doenças do Cão/tratamento farmacológico , Cães , Humanos , Neoplasias/tratamento farmacológico
2.
Vet Comp Oncol ; 15(2): 525-533, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26792388

RESUMO

Cancer is a prevalent cause of mortality in Bernese mountain dogs (BMDs). Circulating microRNAs (miRNAs) are found in blood and have been identified as promising biomarkers in various neoplastic diseases in humans. In the current study, the expression profile of different types of miRNAs was investigated in healthy BMDs and BMDs with cancer. Seven healthy and six non-treated BMDs with cancer [four with disseminated histiocytic sarcomas (DHS)] were enrolled in this study. Clinical evaluations including physical examination, blood analysis, urinalysis and diagnostic imaging were performed on all dogs. Twenty-four different miRNAs were profiled from RNA isolated from whole blood preserved in PAXgene® tubes using quantitative real-time PCR (qPCR). The miRNA let-7g was significantly down-regulated in dogs with cancer (P = 0.002) and dogs with DHS (P = 0.011) compared with healthy controls. This miRNA is a known tumour suppressor and further analyses are warranted to assess its value as a non-invasive biomarker for early detection of different types of cancer in BMDs.


Assuntos
Carcinoma/veterinária , Doenças do Cão/metabolismo , Sarcoma Histiocítico/veterinária , MicroRNAs/metabolismo , Animais , Carcinoma/sangue , Carcinoma/metabolismo , Estudos de Casos e Controles , Doenças do Cão/sangue , Cães , Regulação para Baixo , Feminino , Sarcoma Histiocítico/sangue , Sarcoma Histiocítico/metabolismo , Masculino , MicroRNAs/sangue , MicroRNAs/genética , Estudos Prospectivos , Reação em Cadeia da Polimerase em Tempo Real/veterinária
3.
Acta Otolaryngol Suppl ; 543: 183-5, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10909015

RESUMO

Accumulation and re-breathing of CO2 in expired air has been suggested as one possible explanation for the strong association between prone sleeping position and sudden infant death syndrome (SIDS). This preliminary study applying a modern computational fluid dynamics (CFD) program to simulate the aerodynamics in an infant cot supports the idea that accumulation of expired air may occur in the prone position. The literature dealing with the potential association between re-breathing of accumulated CO2 and SIDS is briefly reviewed.


Assuntos
Ar , Leitos , Simulação por Computador/estatística & dados numéricos , Morte Súbita do Lactente/etiologia , Dióxido de Carbono/metabolismo , Humanos , Recém-Nascido , Decúbito Ventral , Respiração
7.
Scand J Rheumatol ; 15(1): 37-40, 1986.
Artigo em Inglês | MEDLINE | ID: mdl-3515526

RESUMO

Twenty-nine adult rheumatic patients who were taking 500 mg naproxen at bedtime and had a certain degree of morning stiffness despite this medication took part in a randomized double-blind cross-over study in which the duration of morning stiffness after evening doses of 500 mg enteric-coated naproxen tablets was compared with that after identical doses of plain naproxen tablets. The duration of morning stiffness was significantly shorter after taking enteric-coated tablets (p less than 0.01), and the mean plasma naproxen morning concentration was 34% higher (p = 0.01). Since the results were unambiguous in such a small group of patients, they are judged to be of considerable clinical value.


Assuntos
Artrite Reumatoide/fisiopatologia , Naproxeno/administração & dosagem , Adulto , Idoso , Artrite Reativa/fisiopatologia , Ritmo Circadiano , Ensaios Clínicos como Assunto , Método Duplo-Cego , Elasticidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Naproxeno/sangue , Cooperação do Paciente , Distribuição Aleatória , Comprimidos , Comprimidos com Revestimento Entérico , Tempo , Fatores de Tempo
8.
Nord Vet Med ; 36(1-2): 1-12, 1984.
Artigo em Inglês | MEDLINE | ID: mdl-6728668

RESUMO

Arterial pH, oxygen and carbon dioxide tensions, and standard bicarbonate, as well as serum electrolytes (Na, Cl, K, inorganic P, Ca and anion gap) have been investigated in bitches with pyometra. A respiratory alkalosis was a common finding in the patients, and a smaller group showed a metabolic acidosis of mixed origin superimposed on the respiratory alkalosis. In this group 4 out of 9 patients died. In addition, the patients showed moderate electrolyte disturbances indicating a "sick cell syndrome" and a mild to severe renal dysfunction.


Assuntos
Doenças do Cão/sangue , Doenças Uterinas/veterinária , Equilíbrio Ácido-Base , Animais , Cães , Eletrólitos/sangue , Feminino , Masculino , Supuração , Doenças Uterinas/sangue
9.
Nord Vet Med ; 32(9): 378-86, 1980 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-7433016

RESUMO

An investigation on the pathophysiological mechanisms underlying the hypoalbuminaemia and the hypercholesterolaemia of the pyometra syndrome in dogs was performed on 15 patients. The control material consisted of blood from 15 and urine from 6 healthy dogs. The presence of intrahepatic cholestasis in most of the dogs was indicated by an increase of serum alkaline phosphatases and phosphodiesterase I, and by the morphological demonstration of bile pigment retention in liver biopsy material. Serum cholesterol (total- and free-) was positively correlated with serum phospholipids, alkaline phosphatases and phosphodiesterase I, as regularly seen in cholestatic syndromes. Fibrinogen and alpha 2-globulins were increased in most patients. Albumin was inversely related to these parameters, and the main cause of the hypoalbuminaemia was probably the presence of an "acute phase reaction". The levels of coagulation factors in plasma were not lowered. Enzyme markers of hepatocellular injury (ALAT, OCT) were not increased, but on the contrary significantly lowered. The possible presence of enzyme inhibitors as the cause of the decrease of ALAT and OCT is discussed.


Assuntos
Colestase/veterinária , Doenças do Cão/fisiopatologia , Doenças Uterinas/veterinária , Animais , Proteínas Sanguíneas/análise , Colestase/etiologia , Colestase/fisiopatologia , Creatina/sangue , Cães , Enzimas/sangue , Feminino , Lipídeos/sangue , Fígado/patologia , Proteinúria/etiologia , Supuração , Doenças Uterinas/complicações , Doenças Uterinas/fisiopatologia
10.
Nord Vet Med ; 32(6): 255-68, 1980 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-7433012

RESUMO

Results on haemoglobin, PCV, serum proteins, blood urea nitrogen, creatinine, cholesterol, bilirubin and some serum enzymes in bitches with clinical pyometra were compared with the degree of polydipsia, anorexia and dehydration in the same patients, and with their plasma progesterone levels. The findings indicate that the pyometra syndrome includes a liver derangement--i.e. cholestasis--in addition to changes in bone marrow activity and renal function as shown previously. Autopsic results also indicate the presence of an endotoxic influence upon the lung function.


Assuntos
Doenças do Cão/sangue , Doenças Uterinas/veterinária , Fosfatase Alcalina/sangue , Animais , Aspartato Aminotransferases/sangue , Bilirrubina/sangue , Nitrogênio da Ureia Sanguínea , Colesterol/sangue , Creatinina/sangue , Cães , Feminino , Hematócrito , Hemoglobinas/análise , L-Lactato Desidrogenase/sangue , Supuração , Doenças Uterinas/sangue
11.
Nord Vet Med ; 31(6): 251-7, 1979 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-573469

RESUMO

The article deals with the anamnesis and clinical status of pyometra patients at the time of admission for treatment. The average age of 119 pyometra bitches was 7.8 years. About 80 patients were examined for clinical signs of dehydration and hypoperfusion. Such signs were present in up to 80% of the patients, although only about 1/3 seemed weak and in a poor condition. Previous treatment with oral gestagens did not seem to influence the pyometra incidence. However, 14% of the bitches had been given oestrogens (stillbestrol) during the pyometra-associated season.


Assuntos
Doenças do Cão , Endometrite/veterinária , Fatores Etários , Animais , Doenças do Cão/diagnóstico , Cães , Endometrite/diagnóstico , Estro , Feminino , Fertilidade , Gravidez
12.
Nord Vet Med ; 31(6): 258-62, 1979 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-482094

RESUMO

The peripheral plasma progesterone levels in bitches with spontaneously developed pyometra did not differ significantly from those in normally cycling or pregnant bitches. The macroscopic ovarian morphology gave no indication of an increased corpus luteum activity. Ovarian follicular cysts were found in 4 out of 31 cases. There was no detectable difference of results between 14 bitches that had received hormonal medication 10 years to 1 week previous to the pyometra diagnosis, and the other patients.


Assuntos
Doenças do Cão/patologia , Endometrite/veterinária , Ovário/patologia , Progesterona/sangue , Animais , Cães , Endometrite/patologia , Feminino
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