Research of injury mapping relationship of lumbar spine in reclined occupants between anthropomorphic test devices and human body model.

PURPOSE: To judge the injury mode and injury severity of the real human body through the measured values of anthropomorphic test devices (ATD) injury indices, the mapping relationship of lumbar injury between ATD and human body model (HBM) was explored. METHODS: Through the ATD model and HBM simulation, the mapping relationship of lumbar injury between the 2 subjects was explored. The sled environment consisted of a semi-rigid seat with an adjustable seatback angle and a 3-point seat belt system with a seatback-mounted D-ring. Three seatback recline states of 25°, 45°, and 65° were designed, and the seat pan angle was maintained at 15°. A 23 g, 47 km/h pulse was used. The validity of the finite element model of the sled was verified by the comparison of ATD simulation and test results. ATD model was the test device for human occupant restraint for autonomous vehicles (THOR-AV) dummy model and HBM was the total human model for safety (THUMS) v6.1. The posture of the 2 models was adjusted to adapt to the 3 seat states. The lumbar response of THOR-AV and the mechanical and biomechanical data on L1-L5 vertebrae of THUMS were output, and the response relationship between THOR-AV and THUMS was descriptive statistically analyzed. RESULTS: Both THOR-AV and THUMS were submarined in the 65° seatback angle case. With the change of seatback angle, the lumbar spine axial compression force (Fz) of THOR-AV and THUMS changed in the similar trend. The maximum Fz ratio of THOR-AV to THUMS at 25° and 45° seatback angle cases were 1.6 and 1.7. The flexion moment (My) and the time when the maximum My occurred in the 2 subjects were very different. In particular, the form of moment experienced by the L1 - L5 vertebrae of THUMS also changed. The changing trend of My measured by THOR-AV over time can reflect the changing trend of maximum stress of L1 and L2 of THUMS. CONCLUSION: The Fz of ATD and HBM presents a certain proportional relationship, and there is a mapping relationship between the 2 subjects on Fz. The mapping function can be further clarified by applying more pulses and adopting more seatback angles. It is difficult to map My directly because they are very different in ATD and HBM. The My of ATD and stress of HBM lumbar showed a similar change trend over time, and there may be a hidden mapping relationship.

Optimizing vehicle Front-End structure for e-bike rider Safety: An advanced Multi-Objective approach using injury prediction models.

A multi-objective optimization method based on an injury prediction model is proposed to address the increasingly prominent safety issues for e-bike riders in Chinese road traffic. This method aims to enhance the protective effect of vehicle front-end for e-bike riders by encompassing a broader range of test scenarios. Initially, large-scale rider injury response data were collected using automated Madymo simulations. A machine learning model was then trained to accurately predict the risk of rider injury under varied crash conditions. Subsequently, this model was integrated into a multi-objective optimization framework, combined with multi-criteria decision analysis, to effectively evaluate and rank various design alternatives on the Pareto frontier. This process entailed a comparative analysis of the design in a baseline scenario before and after optimization, focusing on both kinematic and injury responses of riders. Through detailed injury mechanism analysis, key design variables such as the height of the hood front and the width of the bumper were identified. This led to the proposal of specific optimization strategies for these structural parameters. The results from this study demonstrate that the proposed optimization method not only guides the design process accurately and efficiently but also balances the injury risks across different body parts. This approach significantly reduces the injury risk for riders in car-to-e-bike collisions and provides actionable insights for vehicle design enhancements.

Trajectory planning framework for autonomous vehicles based on collision injury prediction for vulnerable road users.

Due to the escalating occurrence and high casualty rates of accidents involving Electric Two-Wheelers (E2Ws), it has become a major safety concern on the roads. Additionally, with the widespread adoption of current autonomous driving technology, a greater challenge has arisen for the safety of vulnerable road participants. Most existing trajectory planning methods primarily focus on the safety, comfort, and dynamics of autonomous vehicles themselves, often overlooking the protection of vulnerable road users (VRUs), typically E2W riders. This paper aims to investigate the kinematic response of E2Ws in vehicle collisions, including the 15 ms Head Injury Criterion (HIC15). It analyzes the impact of key collision parameters on head injuries, establishes injury prediction models for anticipated scenarios, and proposes a trajectory planning framework for autonomous vehicles based on predicting head injuries of VRUs. Firstly, a multi-rigid-body model of two-wheeler-vehicle collision was established based on a real accident database, incorporating four critical collision parameters (initial collision velocity, initial collision position, and collision angle). The accuracy of the multi-rigid-body model was validated through verifications with real fatal accidents to parameterize the collision scenario. Secondly, a large-scale effective crash dataset has been established by the multi-parameterized crash simulation automation framework combined with Monte Carlo sampling algorithm. The training and testing of the injury prediction model were implemented based on the MLP + XGBoost regression algorithm on this dataset to explore the potential relationship between the head injuries of the E2W riders and the crash variables. Finally, based on the proposed injury prediction model, this paper generated a trajectory planning framework for autonomous vehicles based on head collision injury prediction for VRUs, aiming to achieve a fair distribution of collision risks among road users. The accident reconstruction results show that the maximum error in the final relative positions of the E2W, the car, and the E2W rider compared to the real accident scene is 11 %, demonstrating the reliability of the reconstructed model. The injury prediction results indicate that the MLP + XGBoost regression prediction model used in this article achieved an R2 of 0.92 on the test set. Additionally, the effectiveness and feasibility of the proposed trajectory planning algorithm were validated in a manually designed autonomous driving traffic flow scenario.

Comprehensively characterizing heterogeneous and transversely isotropic properties of femur cortical bones.

Comprehensive characterization of the transversely isotropic mechanical properties of long bones along both the longitudinal and circumferential gradients is crucial for developing accurate mathematical models and studying bone biomechanics. In addition, mechanical testing to derive elastic, plastic, and failure properties of bones is essential for modeling plastic deformation and failure of bones. To achieve these, we machined a total of 336 cortical specimens, including 168 transverse and 168 longitudinal specimens, from four different quadrants of seven different sections of 3 bovine femurs. We conducted three-point bending tests of these specimens at a loading rate of 0.02 mm/s. Young's modulus, yield stress, tangential modulus, and effective plastic strain for each specimen were derived from correction equations based on classical beam theory. Our statistical analysis reveals that the longitudinal gradient has a significant effect on the Young's modulus, yield stress, and tangential modulus of both longitudinal and transverse specimens, whereas the circumferential gradient significantly influences the Young's modulus, yield stress, and tangential modulus of transverse specimens only. The differences in Young's modulus and yield stress between longitudinal specimens from different sections are greater than 40%, whereas those between transverse specimens are approximately 30%. The Young's modulus and yield stress of transverse specimens in the anterior quadrant were 18.81%/15.46% and 18.34%/14.88% higher than those in the posterior and lateral quadrants, respectively. There is no significant interaction between the longitudinal gradient and the circumferential gradient. Considering the transverse isotropy, it is crucial to consider loading direction when investigating the impact of circumferential gradients in the anterior, lateral, medial, and posterior directions. Our findings indicate that the conventional assumption of homogeneity in simulating the cortical bone of long bones may have limitations, and researchers should consider the anatomical position and loading direction of femur specimens for precise prediction of mechanical responses.

A compendium of genetic regulatory effects across pig tissues.

The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biological discovery and exploitation in animal breeding and human biomedicine. Here we show results from the pilot phase of PigGTEx by processing 5,457 RNA-sequencing and 1,602 whole-genome sequencing samples passing quality control from pigs. We build a pig genotype imputation panel and associate millions of genetic variants with five types of transcriptomic phenotypes in 34 tissues. We evaluate tissue specificity of regulatory effects and elucidate molecular mechanisms of their action using multi-omics data. Leveraging this resource, we decipher regulatory mechanisms underlying 207 pig complex phenotypes and demonstrate the similarity of pigs to humans in gene expression and the genetic regulation behind complex phenotypes, supporting the importance of pigs as a human biomedical model.

Learning functional conservation between human and pig to decipher evolutionary mechanisms underlying gene expression and complex traits.

Assessment of genomic conservation between humans and pigs at the functional level can improve the potential of pigs as a human biomedical model. To address this, we developed a deep learning-based approach to learn the genomic conservation at the functional level (DeepGCF) between species by integrating 386 and 374 functional profiles from humans and pigs, respectively. DeepGCF demonstrated better prediction performance compared with the previous method. In addition, the resulting DeepGCF score captures the functional conservation between humans and pigs by examining chromatin states, sequence ontologies, and regulatory variants. We identified a core set of genomic regions as functionally conserved that plays key roles in gene regulation and is enriched for the heritability of complex traits and diseases in humans. Our results highlight the importance of cross-species functional comparison in illustrating the genetic and evolutionary basis of complex phenotypes.

PRDX1 Cys52Ser variant alleviates nonalcoholic steatohepatitis by reducing inflammation in mice.

OBJECTIVE: Peroxiredoxin 1 (PRDX1) is a peroxidase and guards against oxidative stress by scavenging intracellular peroxides, whereas it also has been shown to stimulate inflammatory response by functioning as a chaperone protein. The potential in vivo link between PRDX1's peroxidase activity and its pro-inflammatory activity remains elusive. METHODS: We generated peroxidase-dead PRDX1 variant mice by mutating its peroxidatic cysteine at 52 (Cys52) to serine, here referred to as PRDX1Cys52Ser. Trx-TrxR-NADPH coupled activity assay was applied to evaluate the peroxidase activity of global PRDX in PRDX1Cys52Ser variant mice. PRDX1Cys52Ser mice and their wild-type littermates were subjected to western diet or methionine and choline deficient diet feeding. NASH phenotypes were assessed through different analyses including physiological measurements, immunohistochemical staining, and quantitative PCR (qPCR). RNA sequencing, qPCR and western blotting were used to reveal and validate any changes in the signaling pathways responsible for the altered NASH phenotypes observed between WT and PRDX1Cys52Ser variant mice. RESULTS: PRDX1Cys52Ser variant mice showed impaired global PRDX peroxidase activity and reduced susceptibility to diet-induced NASH and liver fibrosis. Mechanistically, PRDX1 Cys52Ser variant suppressed NF-κB signaling and STAT1 signaling pathways that are known to promote inflammation and NASH. CONCLUSION: The peroxidatic Cys52 of PRDX1 is required for its pro-inflammatory activity in vivo. This study further suggests that PRDX1 may play dual but opposing roles in NASH.

A New Stress-Based Formulation for Modeling Notched Fiber-Reinforced Laminates.

Laminated plates are often modeled with infinite dimensions in terms of the so-called Whitney-Nuismer (WN) stress criteria, which form a theoretical basis for predicting the residual properties of open-hole structures. Based upon the WN stress criteria, this study derived a new formulation involving finite width; the effects of notch shape and size on the applicability of new formulae and the tensile properties of carbon-fiber-reinforced plastic (CFRP) laminates were investigated via experimental and theoretical analyses. The specimens were prepared by using laminates reinforced by plain woven carbon fiber fabrics and machined with or without an open circular hole or a straight notch. Standard tensile tests were performed and measured using the digital image correlation (DIC) technique, aiming to characterize the full-field surface strain. Continuum damage mechanics (CDMs)-based finite element models were developed to predict the stress concentration factors and failure processes of notched specimens. The characteristic distances in the stress criterion models were calibrated using the experimental results of un-notched and notched specimens, such that the failure of carbon fiber laminates with or without straight notches could be analytically predicted. The experimental results demonstrated well the effectiveness of the present formulations. The new formula provides an effective approach to implementing a finite-width stress criterion for evaluating the tensile properties of notched fiber-reinforced laminates. In addition, the notch size has a great effect on strength prediction while the fiber direction has a great influence on the fracture mode.

A novel approach to investigate effects of front-end structures on injury response of e-bike riders: Combining Monte Carlo sampling, automatic operation, and data mining.

Transportation safety related to e-bikes is becoming more problematic with the growing popularity in recent decade years, however, rare studies focused on the protection for e-bike riders in traffic accidents. This paper aimed to investigate the relationship between vehicle front-end structures and rider's injury based on a novel approach including modeling, sampling, and analyzing. Firstly, a parametrized model for front-end structures of the vehicle was developed with nine parameters to realize the standardization of multi-body models of car to e-bike collision considering three stature riders and different impacting velocities. Secondly, a framework, combining Monte Carlo sampling for twelve initial variables and automatic operation for 1000 impact simulations, was built to obtain valid results automatically and then to construct a big dataset. Finally, according to the sensitive variables to riders' vulnerable regions, the decision tree algorithm was further adopted to develop the decision or prediction model on injuries. The novel approach achieved the stochastical generation of vehicle shapes and the automatic operation of multi-body models. The results showed that the rider's head, pelvis, and thighs were more vulnerable to being injured in the car to e-bike perpendicular accidents. The three decision tree models (HIC15, lateral force of pelvis, bending moment of upper leg) were validated to be accurate and reliable according to the confusion matrix with the precision of more than 80% and the receiver operating characteristic curves (ROC) with the under area more than 85%. Based on decision tree models, not only the effects of front-end structural parameters on the corresponding injury but also the interaction mechanism between various variables can be clearly interpreted. Each route from the same root node to hierarchical middle nodes then to various leaf nodes represented a decision-making process. And the different branches under the same decision node directly illustrated the correlation between variables, which is highly readable and comprehensible. During the safety performance design of front-end structures, the rational value of variables could be decided according to decision routes that resulted in lower injury levels; Even if the accident was inevitable, the collision parameters could be controlled within a certain range for the least injury according to the prediction rules. Based on the novel framework coupling Monte Carlo sampling and automatic operation, it's foreseeable to apply the parametric and standard car-to-e-bike collision models to develop the virtual test system and to optimize front-end shapes for rider's protection.

An intelligent method for accident reconstruction involving car and e-bike coupling automatic simulation and multi-objective optimizations.

Car-electric bicycle (e-bike) accidents have been the subject of strong attention due to the widespread usage of e-bikes and a high casualty rate for their riders. Manually conducted accident reconstruction is based on the trial-and-error method with a limited number of parameter combinations, which makes it time-consuming and subjective. This paper aims to develop an intelligent method for accurate, high-efficient reconstruction of accidents involving cars and e-bikes. First, an automatic operation framework, which can drive the MADYMO program and perform results analysis automatically, was built with four multi-objective optimization algorithms available - NSGA-Ⅱ, NCGA, AMGA, and MOPS; The optimization condition was controlled with 12 design variables, 5 objective functions, and 3 constraints. Then, a real e-bike accident with surveillance video was reconstructed through the proposed framework to verify its validity using comparisons of simulated and actual rest positions, initial variables, kinematic response, and head injury. Lastly, the simulation data were used to study the effects of the initial variables on objectives with a multiple linear regression model. The results showed that it took only about 24 h in total for optimization with 480 automatic operations. Optimal conditions were searched at run numbers of 469, 430, 323, and 474 for NSGA-Ⅱ, NCGA, AMGA, and MOPS, respectively. NSGA-Ⅱ had the best performance for e-bike accident reconstruction with average errors of objectives below 5%; Good consistencies for the rider's kinematic response in three stages after collision were observed between simulations and screenshots from the surveillance video, as well as for velocities between the simulation and those estimated from the surveillance video and for head injury between the simulation and the medical report. In contrast to the subjective trial-and-error method that highly depends on the analyst's intuition and experience, this intelligent method is based on multi-objective optimization theory, with which results can be optimized in terms of the automatic change of initial variables. All the above comparisons demonstrate that the method is valid for effectively improving efficiency without simultaneously compromising accuracy. This intelligent method, coupling automatic simulation and multi-objective optimization, can also be applied to other accident reconstructions, and the significant order of initial variables' effects on objectives can provide recommendations for further reconstructions.

A study on the cyclist head kinematic responses in electric-bicycle-to-car accidents using decision-tree model.

Due to the high frequent traffic accidents involving electric bicycles (E-bike), it urgently needs improved protection of cyclists, especially their heads. In this study, by adjusting the initial impact velocities of E-bike and car, initial impact angle between E-bike and car, initial E-bike impact location, and body size of cyclist, 1512 different accident conditions were constructed and simulated using a verified E-bike-to-car impact multi-body model. The cyclist's head kinematic responses including the head relative impact velocity, WAD (Wrap around distance) of head impact location and HIC15 (15 ms Head Injury Criterion) were collected from simulation results to make up a dataset for data mining. The decision tree models of cyclist's head kinematic responses were then created from this dataset and verified accordingly. Based on simulated results obtained from decision tree models, it can be found as follows. 1. In the E-bike-to-car accidents, the average head impact relative velocity and WAD of head impact location are higher than those in the car-to-pedestrian accidents. 2. Increasing the initial impact velocity of car can increase the cyclist's head relative impact velocity, WAD of head impact location, and HIC15. 3. The WAD of cyclist's head impact location is also significantly affected by the initial impact angle between E-bike and car and body size of cyclist: the WAD of head impact location becomes higher with increasing initial impact angle between E-bike and car and body size of cyclist. 4. The effects of initial E-bike impact location on the WAD of cyclist's head impact location is not significant when initial E-bike impact location is concentrated in the region of 0.25 m around the centerline of the car.

Is the 0.2%-Strain-Offset Approach Appropriate for Calculating the Yield Stress of Cortical Bone?

The 0.2% strain offset approach is mostly used to calculate the yield stress and serves as an efficient method for cross-lab comparisons of measured material properties. However, it is difficult to accurately determine the yield of the bone. Especially when computational models require accurate material parameters, clarification of the yield point is needed. We tested 24 cortical specimens harvested from six bovine femora in three-point bending mode, and 11 bovine femoral cortical specimens in the tensile mode. The Young's modulus and yield stress for each specimen derived from the specimen-specific finite element (FE) optimization method was regarded as the most ideal constitutive parameter. Then, the strain offset optimization method was used to find the strain offset closest to the ideal yield stress for the 24 specimens. The results showed that the 0 strain offsets underestimated (- 25%) the yield stress in bending and tensile tests, while the 0.2% strain offsets overestimated the yield stress (+ 65%) in three-point bending tests. Instead, the yield stress determined by 0.007 and 0.05% strain offset for bending and tensile loading respectively, can effectively characterize the biomechanical responses of the bone, thereby helping to build an accurate FE model.

Study on the Long Bone Failure Behaviors Under the Indenter Rigid-Contact by Experiment Analysis and Subject-Specific Simulation.

The bending fracture behaviors of long bone have gained great attention due to the high bending fracture risk during sports events, traffic accidents, and falling incidents, etc. For evaluating bone bending behaviors, most of the previous studies used an indenter in three point bending experiments while the effect of its rigidity was never considered. In this work, using the porcine long bones, the three point bending tests were conducted to explore the bone fracture behaviors under a rigid indenter. In addition to collecting the force applied, the bone fracture dynamic process was recorded by high-speed photography, and the fracture surface profile in mesoscale was observed by the scanning electron microscope (SEM). Based on CT scanning of long bones, the cross section properties of test specimens were calculated by a homemade matlab script for correlating with their failure strengths. Also, a subject-specific finite element (FE) model was developed to identify the outcomes induced by a rigid indenter on simulation. Findings led to conclusions as follows: (1) The tension fracture came with fracture path deflection, which was caused by the bone indentation induced mesoscale crack-opening. Due to this damage before the whole bone fracture, a bone fracture moment correction was established to compensate experimental data. (2) The plastic indentation caused the force fluctuation as suggested by correlation analysis. (3) The bone failure moment correlated with the inertial moment of the bone cross section at the fracture location higher than the traditional cross section area. (4) In the subject-specific simulation, the indentation caused compression fracture under a much lower failure force. Removing the element erosion on the indenter-contacted area only during the validation was verified as a good option to solve this issue.

A study on cyclist head injuries based on an electric-bicycle to car accident reconstruction.

OBJECTIVE: In China, the electric-bicycle (E-bike) has become one of the most common modes of travel. However, the safety of E-bike has not received sufficient attentions, especially in the area of protection of the cyclists' head. METHODS: In this study, an E-bike-to-car accident was reconstructed using MADYMO and LS-DYNA software and head injuries of the cyclist were analyzed. A multi-rigid body model in MADYMO and a head to windshield impact finite element (FE) model using LS-DYNA were separately developed to achieve objectives of the work. RESULTS: Kinematic responses of the cyclist were predicted by the multi-rigid body model to obtain the best reconstructed results compared to those given in the accident report, and the instantaneous linear and angular relative velocities at the onset of contact between the head and windshield, which were used as input loading conditions to the FE model, were obtained. The maximum principal strain (MPS) of skull, and intracranial pressure (ICP), von-Mises stress and MPS (Maximum principal strain) of brain tissue were predicted by the FE model for the head injuries analyses. CONCLUSIONS: The results of accident reconstruction in this study case showed that: (1) The head impact region on the windshield in the E-bike-to-car impact accidents is higher than that in the pedestrian-to-car impact accidents. (2) The skull MPS, ICP, von-Mises stress and MPS of strain can accurately predict the head injury risk, location, etc. (3) The directly impact force caused the skull fracture, and the tensile inertial force torn bridge vein resulting in the subdural hematoma on the opposite side of impact in this accident. (4) The models developed in this study were validated against the reconstructed accident and can be used for further study on head injuries of E-bike's cyclist and helmet design.

The Effect of Formalin Preservation Time and Temperature on the Material Properties of Bovine Femoral Cortical Bone Tissue.

Literature has reported controversial findings on whether formalin affected bone properties, or not, especially when different preservation time durations and temperatures were involved. Hence, accurately and systematically quantifying the effect of formalin on the mechanical properties of bone using a large dataset is crucial for assessing biomechanical responses based on fixed specimens. A total of 154 longitudinal and 149 transverse cuboid-shaped (12 mm × 2 mm × 0.5 mm) specimens from the midsection of 12 bovine femora from six bovines were prepared and assigned to ten groups, including fresh-frozen, formalin-preserved at 25 °C for 4 weeks and 8 weeks, and formalin-preserved at 4 °C for 4 weeks and 8 weeks. All specimens underwent quasi-static three-point bending tests with a loading rate of 0.02 mm/s. The Young's modulus, yield stress, yield strain, tangent modulus, effective plastic strain, ultimate stress, and toughness were calculated by optimizing the material parameters to make the force-displacement curve of the finite element prediction consistent with the experimental curve, combined with specimen-specific finite element models. Preservation time and temperature both had significant effects on the Young's modulus, yield stress, effective plastic strain, yield strain and ultimate stress of cortical bone (p < 0.05). The Young's modulus, yield stress, and ultimate stress of longitudinal specimens decreased significantly with the increase of preservation time, and the yield strain increased significantly. As the preservation temperature increases, the Young's modulus of the transverse sample decreased significantly, and the yield strain increased significantly. The preservation time mainly affects the longitudinal specimens, while the preservation temperature mainly affects the transverse specimens. Formalin preservation of bovine femoral cortical bones at a lower temperature and less than 4 weeks is recommended for biomechanical testing.

The effect of storage time in saline solution on the material properties of cortical bone tissue.

BACKGROUND: The use of saline in preserving bone specimens may affect the mechanical properties of specimens. Yet, the reported effects varied and contradicted to each other, with a lack of investigating constitutive material parameters. Therefore, we quantified the effects of preservation time on the constitutive properties of cortical bone. METHODS: We collected 120 specimens from the mid-diaphysis of six male bovine femora, which were assigned to five groups, including fresh-frozen for 60 days (-20 °C), storage in saline for 3, 10, 36 and 60 days (25 °C). All specimens underwent quasi-static three-point bending tests with a loading rate of 0.02 mm/s. Using the optimization method combined with specimen-specific finite element models, the Young's modulus, tangent modulus, yield stress, effective plastic strain, yield strain, ultimate stress, and toughness were calculated. FINDINGS: Saline preservation resulted in a significant decrease of Young's modulus, yield stress, ultimate stress and pre-yield toughness (P < 0.001), and a significant increase of effective plastic strain (P = 0.034). After 10 days of preservation, yield stress and pre-yield toughness decreased -14.9% and -21.4%, respectively, and they continued to decrease with longer preservation time. After 36 days of preservation, Young's modulus and ultimate stress decreased -19.2% and -17.3%, respectively, and continued to decrease with longer preservation time. Our data also showed changes of material properties collected after 3-day saline preservation, while the low statistical power must be considered for this group. INTERPRETATION: Saline preservation impacts on mechanical properties of cortical bone tissue and the effect is already observable after 3 days.

A Study of the Effect of the Front-End Styling of Sport Utility Vehicles on Pedestrian Head Injuries.

BACKGROUND: The number of sport utility vehicles (SUVs) on China market is continuously increasing. It is necessary to investigate the relationships between the front-end styling features of SUVs and head injuries at the styling design stage for improving the pedestrian protection performance and product development efficiency. METHODS: Styling feature parameters were extracted from the SUV side contour line. And simplified finite element models were established based on the 78 SUV side contour lines. Pedestrian headform impact simulations were performed and validated. The head injury criterion of 15 ms (HIC15) at four wrap-around distances was obtained. A multiple linear regression analysis method was employed to describe the relationships between the styling feature parameters and the HIC15 at each impact point. RESULTS: The relationship between the selected styling features and the HIC15 showed reasonable correlations, and the regression models and the selected independent variables showed statistical significance. CONCLUSIONS: The regression equations obtained by multiple linear regression can be used to assess the performance of SUV styling in protecting pedestrians' heads and provide styling designers with technical guidance regarding their artistic creations.

A parametric ribcage geometry model accounting for variations among the adult population.

The objective of this study is to develop a parametric ribcage model that can account for morphological variations among the adult population. Ribcage geometries, including 12 pair of ribs, sternum, and thoracic spine, were collected from CT scans of 101 adult subjects through image segmentation, landmark identification (1016 for each subject), symmetry adjustment, and template mesh mapping (26,180 elements for each subject). Generalized procrustes analysis (GPA), principal component analysis (PCA), and regression analysis were used to develop a parametric ribcage model, which can predict nodal locations of the template mesh according to age, sex, height, and body mass index (BMI). Two regression models, a quadratic model for estimating the ribcage size and a linear model for estimating the ribcage shape, were developed. The results showed that the ribcage size was dominated by the height (p=0.000) and age-sex-interaction (p=0.007) and the ribcage shape was significantly affected by the age (p=0.0005), sex (p=0.0002), height (p=0.0064) and BMI (p=0.0000). Along with proper assignment of cortical bone thickness, material properties and failure properties, this parametric ribcage model can directly serve as the mesh of finite element ribcage models for quantifying effects of human characteristics on thoracic injury risks.

A simulation study on the efficacy of advanced belt restraints to mitigate the effects of obesity for rear-seat occupant protection in frontal crashes.

OBJECTIVE: Recent field data analyses have shown that the safety advantages of rear seats relative to the front seats have decreased in newer vehicles. Separately, the risks of certain injuries have been found to be higher for obese occupants. The objective of this study is to investigate the effects of advanced belt features on the protection of rear-seat occupants with a range of body mass index (BMI) in frontal crashes. METHODS: Whole-body finite element human models with 4 BMI levels (25, 30, 35, and 40 kg/m2) developed previously were used in this study. A total of 52 frontal crash simulations were conducted, including 4 simulations with a standard rear-seat, 3-point belt and 48 simulations with advanced belt features. The parameters varied in the simulations included BMI, load limit, anchor pretensioner, and lap belt routing relative to the pelvis. The injury measurements analyzed in this study included head and hip excursions, normalized chest deflection, and torso angle (defined as the angle between the hip-shoulder line and the vertical direction). Analyses of covariance were used to test the significance (P <.05) of the results. RESULTS: Higher BMI was associated with greater head and hip excursions and larger normalized chest deflection. Higher belt routing increased the hip excursion and torso angle, which indicates a higher submarining risk, whereas the anchor pretensioner reduced hip excursion and torso angle. Lower load limits decreased the normalized chest deflection but increased the head excursion. Normalized chest deflection had a positive correlation with maximum torso angle. Occupants with higher BMI have to use higher load limits to reach head excursions similar to those in lower BMI occupants. DISCUSSION AND CONCLUSION: The simulation results suggest that optimizing load limiter and adding pretensioner(s) can reduce injury risks associated with obesity, but conflicting effects on head and chest injuries were observed. This study demonstrated the feasibility and importance of using human models to investigate protection for occupants with various BMI levels. A seat belt system capable of adapting to occupant size and body shape will improve protection for obese occupants in rear seats.

Optimizing the passenger air bag of an adaptive restraint system for multiple size occupants.

OBJECTIVE: The development of the adaptive occupant restraint system (AORS) has led to an innovative way to optimize such systems for multiple size occupants. An AORS consists of multiple units such as adaptive air bags, seat belts, etc. During a collision, as a supplemental protective device, air bags can provide constraint force and play a role in dissipating the crash energy of the occupants' head and thorax. This article presents an investigation into an adaptive passenger air bag (PAB). METHODS: The purpose of this study is to develop a base shape of a PAB for different size occupants using an optimization method. Four typical base shapes of a PAB were designed based on geometric data on the passenger side. Then 4 PAB finite element (FE) models and a validated sled with different size dummy models were developed in MADYMO (TNO, Rijswijk, The Netherlands) to conduct the optimization to obtain the best baseline PAB that would be used in the AORS. The objective functions-that is, the minimum total probability of injuries (∑Pcomb) of the 5th percentile female and 50th and 95th percentile male dummies-were adopted to evaluate the optimal configurations. The injury probability (Pcomb) for each dummy was adopted from the U.S. New Car Assessment Program (US-NCAP). RESULTS: The parameters of the AORS were first optimized for different types of PAB base shapes in a frontal impact. Then, contact time duration and force between the PAB and dummy head/chest were optimized by adjusting the parameters of the PAB, such as the number and position of tethers, lower the Pcomb of the 95th percentile male dummy. CONCLUSIONS: According to the optimization results, 4 typical PABs could provide effective protection to 5th and 50th percentile dummies. However, due to the heavy and large torsos of the 95th percentile occupants, the current occupant restraint system does not demonstrate satisfactory protective function, particularly for the thorax.