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1.
Orthod Fr ; 87(2): 229-43, 2016 Jun.
Artigo em Francês | MEDLINE | ID: mdl-27358007

RESUMO

Vertical dentoalveolar discrepancies are a common problem in orthodontic patients but are often difficult to treat with traditional mechanics. This case report illustrates the successful treatment of overerupted mandibular incisors via the indirect use of miniscrew anchorage. A woman (age, 22 years 9 months) had chief complaints of maxillary incisor protrusion and crooked teeth. An excessive curve of Spee caused by elongation of the mandibular incisors was also found. The patient was diagnosed with a severe Class II Division 1 malocclusion and a deep overbite. After extraction of the mandibular first premolars and the subsequent leveling phase, the elongated incisors were intruded with a novel method, which involved the combined use of sectional archwires and miniscrews placed in the premolar areas. After the procedure, the mandibular incisors had been intruded by 6.5 mm with no undesirable side effects. The total active treatment period was 42 months. The resultant occlusion and satisfactory facial profile were maintained after 30 months of retention. Our novel intrusion approach shows potential for correcting a deep overbite.


Assuntos
Parafusos Ósseos , Incisivo/patologia , Má Oclusão Classe II de Angle/terapia , Procedimentos de Ancoragem Ortodôntica/instrumentação , Sobremordida/terapia , Técnicas de Movimentação Dentária/instrumentação , Dente Pré-Molar/cirurgia , Cefalometria/métodos , Feminino , Seguimentos , Humanos , Miniaturização , Contenções Ortodônticas , Fios Ortodônticos , Planejamento de Assistência ao Paciente , Radiografia Panorâmica , Extração Dentária/métodos , Resultado do Tratamento , Adulto Jovem
2.
Am J Orthod Dentofacial Orthop ; 143(4 Suppl): S113-24, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23540627

RESUMO

Vertical dentoalveolar discrepancies are a common problem in orthodontic patients but are often difficult to treat with traditional mechanics. This case report illustrates the successful treatment of overerupted mandibular incisors via the indirect use of miniscrew anchorage. A woman (age, 22 years 9 months) had chief complaints of maxillary incisor protrusion and crooked teeth. An excessive curve of Spee caused by elongation of the mandibular incisors was also found. The patient was diagnosed with a severe Class II Division 1 malocclusion and a deep overbite. After extraction of the mandibular first premolars and the subsequent leveling phase, the elongated incisors were intruded with a novel method, which involved the combined use of sectional archwires and miniscrews placed in the premolar areas. After the procedure, the mandibular incisors had been intruded by 6.5 mm with no undesirable side effects. The total active treatment period was 42 months. The resultant occlusion and satisfactory facial profile were maintained after 30 months of retention. Our novel intrusion approach shows potential for correcting a deep overbite.


Assuntos
Incisivo/patologia , Procedimentos de Ancoragem Ortodôntica/instrumentação , Sobremordida/terapia , Técnicas de Movimentação Dentária/métodos , Parafusos Ósseos , Cefalometria , Arco Dental/patologia , Feminino , Humanos , Mandíbula , Fios Ortodônticos , Erupção Dentária , Técnicas de Movimentação Dentária/instrumentação , Adulto Jovem
3.
Bone ; 53(1): 204-15, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23246671

RESUMO

Bone cells respond to mechanical stimuli by producing a variety of biological signals, and one of the earliest events is intracellular calcium ([Ca(2+)](i)) mobilization. Our recently developed ex vivo live [Ca(2+)](i) imaging system revealed that bone cells in intact bone explants showed autonomous [Ca(2+)](i) oscillations, and osteocytes specifically modulated these oscillations through gap junctions. However, the behavior and connectivity of the [Ca(2+)](i) signaling networks in mechanotransduction have not been investigated in intact bone. We herein introduce a novel fluid-flow platform for probing cellular signaling networks in live intact bone, which allows the application of capillary-driven flow just on the bone explant surface while performing real-time fluorogenic monitoring of the [Ca(2+)](i) changes. In response to the flow, the percentage of responsive cells was increased in both osteoblasts and osteocytes, together with upregulation of c-fos expression in the explants. However, enhancement of the peak relative fluorescence intensity was not evident. Treatment with 18 α-GA, a reversible inhibitor of gap junction, significantly blocked the [Ca(2+)](i) responsiveness in osteocytes without exerting any major effect in osteoblasts. On the contrary, such treatment significantly decreased the flow-activated oscillatory response frequency in both osteoblasts and osteocytes. The stretch-activated membrane channel, when blocked by Gd(3+), is less affected in the flow-induced [Ca(2+)](i) response. These findings indicated that flow-induced mechanical stimuli accompanied the activation of the autonomous [Ca(2+)](i) oscillations in both osteoblasts and osteocytes via gap junction-mediated cell-cell communication and hemichannel. Although how the bone sense the mechanical stimuli in vivo still needs to be elucidated, the present study suggests that cell-cell signaling via augmented gap junction and hemichannel-mediated [Ca(2+)](i) mobilization could be involved as an early signaling event in mechanotransduction.


Assuntos
Osso e Ossos/metabolismo , Sinalização do Cálcio , Estresse Psicológico , Animais , Sequência de Bases , Embrião de Galinha , Primers do DNA , Genes fos , RNA Mensageiro/genética , Reação em Cadeia da Polimerase em Tempo Real , Reação em Cadeia da Polimerase Via Transcriptase Reversa
4.
Eur J Oral Sci ; 113(4): 318-25, 2005 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16048524

RESUMO

Mandibular condylar cartilage differs from primary cartilage in morphological organization of the chondrocytes and in responses to biomechanical stress and humoral factors. For the first time, we describe the expression of Bmp3 mRNA in relation to types I, II and X collagen mRNA (as determined by in situ hybridization) in chondrocytes of the rat mandibular condylar cartilage, femoral articular cartilage, femoral growth plate cartilage, and temporal cartilage, which transiently appeared in the reparative response stage of mandibular ramus fracture healing. In all cartilages evaluated, Bmp3 was expressed in proliferating chondrocytes that expressed type I collagen in condylar cartilage, articular cartilage, and temporal cartilage appearing during fracture healing. Bmp3 was also found in hypertrophic chondrocytes that expressed type X collagen mRNA in all cartilages evaluated. Furthermore, in remodeling bone, Bmp3 mRNA was strongly expressed in active osteoblast cells in periosteal reaction layers formed after fracture. These findings suggest that Bmp3 expression in a special layer of typical articular cartilage may be regulated by mechanical stress stimulation. We also found that Bmp3 was expressed in the periosteal layers of the bone segments near the fracture site during fracture healing.


Assuntos
Proteínas Morfogenéticas Ósseas/metabolismo , Cartilagem Articular/metabolismo , Condrócitos/metabolismo , Lâmina de Crescimento/metabolismo , Côndilo Mandibular/metabolismo , Fraturas Mandibulares/metabolismo , Animais , Proteína Morfogenética Óssea 3 , Proteínas Morfogenéticas Ósseas/genética , Calo Ósseo/citologia , Calo Ósseo/metabolismo , Cartilagem/citologia , Cartilagem/metabolismo , Cartilagem Articular/citologia , Colágeno/genética , Colágeno/metabolismo , Fêmur/citologia , Fêmur/metabolismo , Consolidação da Fratura/fisiologia , Regulação da Expressão Gênica , Lâmina de Crescimento/citologia , Masculino , Côndilo Mandibular/citologia , Periósteo/metabolismo , RNA Mensageiro/análise , Ratos , Ratos Wistar , Estresse Mecânico
6.
Brain Res ; 1036(1-2): 196-201, 2005 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-15725418

RESUMO

Levels of preproenkephalin mRNA expression in trigeminal subnucleus complex by noxious tooth movement stimuli were examined using in situ hybridization. At 24 h, preproenkephalin mRNA expression was significantly upregulated in the ipsilateral trigeminal subnucleus caudalis (P<0.05), and in the subnucleus oralis (P<0.05). These findings suggested that enkephalinergic inhibitory systems could be activated during tooth movement, and that subnucleus oralis may be involved in modulation of the nociception, as well as the subnucleus caudalis.


Assuntos
Vias Aferentes/metabolismo , Encefalinas/genética , Nociceptores/fisiologia , Dor/metabolismo , Precursores de Proteínas/genética , Dente/inervação , Núcleo Inferior Caudal do Nervo Trigêmeo/metabolismo , Animais , Modelos Animais de Doenças , Encefalinas/metabolismo , Lateralidade Funcional/fisiologia , Masculino , Inibição Neural/fisiologia , Aparelhos Ortodônticos/efeitos adversos , Dor/fisiopatologia , RNA Mensageiro/metabolismo , Ratos , Ratos Sprague-Dawley , Dente/fisiologia , Regulação para Cima/fisiologia
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