RESUMO
An unprecedented zeolite supramolecular framework featuring truncated cuboctahedral and truncated octahedral cavities was self-assembled from tetrahedral metal-organic cationic cages and tetrahedral anions. This crystalline porous material could trap iodine and organic dye molecules, and its solid state spin-crossover behavior was affected by guest encapsulation.
RESUMO
Four pairs of chiral supramolecular coordination cages were facilely synthesized, and they could efficiently inhibit amyloid-ß (Aß) aggregation with a high inhibition rate of 0.64-0.86. This research provides a new perspective on the design of chiral Aß inhibitors using supramolecular metal-organic cages.
Assuntos
Peptídeos beta-Amiloides/antagonistas & inibidores , Substâncias Macromoleculares/farmacologia , Estruturas Metalorgânicas/farmacologia , Agregados Proteicos/efeitos dos fármacos , Peptídeos beta-Amiloides/metabolismo , Cristalografia por Raios X , Humanos , Substâncias Macromoleculares/química , Estruturas Metalorgânicas/química , Modelos Moleculares , Conformação Molecular/efeitos dos fármacosRESUMO
Four pairs of enantiomers of water-stable tetrahedral metal-organic cages [Ni4L6](8+) were facilely synthesized. They efficiently stabilized antiparallel G-quadruplex DNA with moderate enantioselectivity, and displayed promising cytotoxicity against the human cancer cell lines HCT116, HepG2 and MCF-7. These results provide a new insight into the rational design of chiral G-quadruplex-based anticancer agents.