1.
ACS Omega
; 6(40): 25972-25981, 2021 Oct 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34660959
RESUMO
A CuO-promoted direct hydrocarboxylation of ethenesulfonyl fluoride (ESF) was developed using carboxylic acid as a nucleophile under mild conditions. A variety of molecules containing both ester group and aliphatic sulfonyl fluoride moiety exhibit great potential in medicinal chemistry and chemical biology. Furthermore, the modification of the known drugs Ibuprofen and Aspirin was also demonstrated.