[Folliculotropic mycosis fungoides]. / Follikulotrope Mycosis fungoides.

BACKGROUND: Folliculotropic mycosis fungoides represents a rare variant of the CD4-positive cutaneous T-cell lymphoma mycosis fungoides. It is characterized by tropism of the lymphocytic infiltrate for hair follicle and other adnexal structures. CASE PRESENTATION: Our patient presented with a 20-year history of pruritic skin lesions, which had been diagnosed as atopic dermatitis. The diagnosis of folliculotropic mycosis fungoides was confirmed by skin biopsy. Since topical therapy was ineffective, systemic therapy was initiated promptly. Treatment with pegylated interferon alpha-2b 25 µg/week led to significant improvement of the skin condition. CONCLUSION: Due to its polymorphic clinical presentation, folliculotropic mycosis fungoides is diagnosed with delay and in a later stage than classical mycosis fungoides. Thus we recommend an early skin biopsy in patients with therapy-resistant pruritic skin lesions.

[Pyogenic granuloma of the oral mucosa]. / Granuloma pyogenicum der Mundschleimhaut.

Pyogenic granuloma is regarded as a vascular proliferation that may result from trauma or local irritation. The most common intraoral site is the gingiva, affected in 75 % of cases. Therapy of pyogenic granuloma consists of surgical excision. Recurrence after excision may occur. In our patient, there were no post-operative complications.

[Lupoid perioral dermatitis as a special form of perioral dermatitis: review of pathogenesis and new therapeutic options]. / Lupoide periorale Dermatitis: Einblick in die Pathogenese und neue Therapieoptionen.

Lupoid perioral dermatitis is classified as a special form of perioral dermatitis with dense aggregations of red-brown papules which display a lupoid infiltrate on diascopy. There are various treatment options ranging from total avoidance of all topical substances to different topical treatment. Cases resistant to therapy require systemic treatment, which, however, is off-label use. In our case we were able to achieve a significant improvement with systemic therapy with isotretinoin over a period of 6 months.

[Spiny hyperkeratosis of the palms and soles]. / Spiny Hyperkeratosis palmaris et plantaris.

Spiny hyperkeratosis of the palms and soles is a rare dermatosis presenting as multiple tiny keratotic plugs on the palms and soles. There are two different forms of spiny keratoderma of the palms and soles - the hereditary form and the acquired form. The latter is usually associated with internal malignancies or systemic disease. Since spiny hyperkeratosis of the palms and soles has been under-reported and under-diagnosed, it is important for dermatologists not to forget this disease in daily practice. We report this rare disease for the first time in the German literature.

[Modern light protection from the view of occupational dermatology]. / Moderner Lichtschutz aus berufsdermatologischer Sicht.

UV-light induced skin cancer is being more and more accepted in Germany as an occupational disease for several jobs with increased UV-light exposure. Over the past 100 years sunscreens with filters against UVB- and UVA-light have been developed. Another development is the use of antioxidants such as vitamin E, vitamin C and herbal agents for additional photoprotection. The evidence supporting these products in their topical and systemic formulation is very variable. The recent changes in the recognition of UV-induced skin cancers as occupational diseases increases the need for preventive strategies which are supported by appropriate clinical studies.