Robust Orientation Estimation from MEMS Magnetic, Angular Rate, and Gravity (MARG) Modules for Human-Computer Interaction.

While the availability of low-cost micro electro-mechanical systems (MEMS) accelerometers, gyroscopes, and magnetometers initially seemed to promise the possibility of using them to easily track the position and orientation of virtually any object that they could be attached to, this promise has not yet been fulfilled. Navigation-grade accelerometers and gyroscopes have long been the basis for tracking ships and aircraft, but the signals from low-cost MEMS accelerometers and gyroscopes are still orders of magnitude poorer in quality (e.g., bias stability). Therefore, the applications of MEMS inertial measurement units (IMUs), containing tri-axial accelerometers and gyroscopes, are currently not as extensive as they were expected to be. Even the addition of MEMS tri-axial magnetometers, to conform magnetic, angular rate, and gravity (MARG) sensor modules, has not fully overcome the challenges involved in using these modules for long-term orientation estimation, which would be of great benefit for the tracking of human-computer hand-held controllers or tracking of Internet-Of-Things (IoT) devices. Here, we present an algorithm, GMVDµK (or simply GMVDK), that aims at taking full advantage of all the signals available from a MARG module to robustly estimate its orientation, while preventing damaging overcorrections, within the context of a human-computer interaction application. Through experimental comparison, we show that GMVDK is more robust to magnetic disturbances than three other MARG orientation estimation algorithms in representative trials.

Benchmarking Dataset of Signals from a Commercial MEMS Magnetic-Angular Rate-Gravity (MARG) Sensor Manipulated in Regions with and without Geomagnetic Distortion.

In this paper, we present the FIU MARG Dataset (FIUMARGDB) of signals from the tri-axial accelerometer, gyroscope, and magnetometer contained in a low-cost miniature magnetic-angular rate-gravity (MARG) sensor module (also known as magnetic inertial measurement unit, MIMU) for the evaluation of MARG orientation estimation algorithms. The dataset contains 30 files resulting from different volunteer subjects executing manipulations of the MARG in areas with and without magnetic distortion. Each file also contains reference ("ground truth") MARG orientations (as quaternions) determined by an optical motion capture system during the recording of the MARG signals. The creation of FIUMARGDB responds to the increasing need for the objective comparison of the performance of MARG orientation estimation algorithms, using the same inputs (accelerometer, gyroscope, and magnetometer signals) recorded under varied circumstances, as MARG modules hold great promise for human motion tracking applications. This dataset specifically addresses the need to study and manage the degradation of orientation estimates that occur when MARGs operate in regions with known magnetic field distortions. To our knowledge, no other dataset with these characteristics is currently available. FIUMARGDB can be accessed through the URL indicated in the conclusions section. It is our hope that the availability of this dataset will lead to the development of orientation estimation algorithms that are more resilient to magnetic distortions, for the benefit of fields as diverse as human-computer interaction, kinesiology, motor rehabilitation, etc.

S2 Heart Sound Detects Aortic Valve Calcification Independent of Hemodynamic Changes in Mice.

Background: Calcific aortic valve disease (CAVD) is often undiagnosed in asymptomatic patients, especially in underserved populations. Although artificial intelligence has improved murmur detection in auscultation exams, murmur manifestation depends on hemodynamic factors that can be independent of aortic valve (AoV) calcium load and function. The aim of this study was to determine if the presence of AoV calcification directly influences the S2 heart sound. Methods: Adult C57BL/6J mice were assigned to the following 12-week-long diets: (1) Control group (n = 11) fed a normal chow, (2) Adenine group (n = 4) fed an adenine-supplemented diet to induce chronic kidney disease (CKD), and (3) Adenine + HP (n = 9) group fed the CKD diet for 6 weeks, then supplemented with high phosphate (HP) for another 6 weeks to induce AoV calcification. Phonocardiograms, echocardiogram-based valvular function, and AoV calcification were assessed at endpoint. Results: Mice on the Adenine + HP diet had detectable AoV calcification (9.28 ± 0.74% by volume). After segmentation and dimensionality reduction, S2 sounds were labeled based on the presence of disease: Healthy, CKD, or CKD + CAVD. The dataset (2,516 S2 sounds) was split subject-wise, and an ensemble learning-based algorithm was developed to classify S2 sound features. For external validation, the areas under the receiver operating characteristic curve of the algorithm to classify mice were 0.9940 for Healthy, 0.9717 for CKD, and 0.9593 for CKD + CAVD. The algorithm had a low misclassification performance of testing set S2 sounds (1.27% false positive, 1.99% false negative). Conclusion: Our ensemble learning-based algorithm demonstrated the feasibility of using the S2 sound to detect the presence of AoV calcification. The S2 sound can be used as a marker to identify AoV calcification independent of hemodynamic changes observed in echocardiography.

A Tensorized Multitask Deep Learning Network for Progression Prediction of Alzheimer's Disease.

With the advances in machine learning for the diagnosis of Alzheimer's disease (AD), most studies have focused on either identifying the subject's status through classification algorithms or on predicting their cognitive scores through regression methods, neglecting the potential association between these two tasks. Motivated by the need to enhance the prospects for early diagnosis along with the ability to predict future disease states, this study proposes a deep neural network based on modality fusion, kernelization, and tensorization that perform multiclass classification and longitudinal regression simultaneously within a unified multitask framework. This relationship between multiclass classification and longitudinal regression is found to boost the efficacy of the final model in dealing with both tasks. Different multimodality scenarios are investigated, and complementary aspects of the multimodal features are exploited to simultaneously delineate the subject's label and predict related cognitive scores at future timepoints using baseline data. The main intent in this multitask framework is to consolidate the highest accuracy possible in terms of precision, sensitivity, F1 score, and area under the curve (AUC) in the multiclass classification task while maintaining the highest similarity in the MMSE score as measured through the correlation coefficient and the RMSE for all time points under the prediction task, with both tasks, run simultaneously under the same set of hyperparameters. The overall accuracy for multiclass classification of the proposed KTMnet method is 66.85 ± 3.77. The prediction results show an average RMSE of 2.32 ± 0.52 and a correlation of 0.71 ± 5.98 for predicting MMSE throughout the time points. These results are compared to state-of-the-art techniques reported in the literature. A discovery from the multitasking of this consolidated machine learning framework is that a set of hyperparameters that optimize the prediction results may not necessarily be the same as those that would optimize the multiclass classification. In other words, there is a breakpoint beyond which enhancing further the results of one process could lead to the downgrading in accuracy for the other.

A study of the longitudinal changes in multiple cerebrospinal fluid and volumetric magnetic resonance imaging biomarkers on converter and non-converter Alzheimer's disease subjects with consideration for their amyloid beta status.

INTRODUCTION: This study aims to determine whether newly introduced biomarkers Visinin-like protein-1 (VILIP-1), chitinase-3-like protein 1 (YKL-40), synaptosomal-associated protein 25 (SNAP-25), and neurogranin (NG) in cerebrospinal fluid are useful in evaluating the asymptomatic and early symptomatic stages of Alzheimer's disease (AD). It further aims to shed new insight into the differences between stable subjects and those who progress to AD by associating cerebrospinal fluid (CSF) biomarkers and specific magnetic resonance imaging (MRI) regions with disease progression, more deeply exploring how such biomarkers relate to AD pathology. METHODS: We examined baseline and longitudinal changes over a 7-year span and the longitudinal interactions between CSF and MRI biomarkers for subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI). We stratified all CSF (140) and MRI (525) cohort participants into five diagnostic groups (including converters) further dichotomized by CSF amyloid beta (Aß) status. Linear mixed models were used to compare within-person rates of change across diagnostic groups and to evaluate the association of CSF biomarkers as predictors of magnetic resonance imaging (MRI) biomarkers. CSF biomarkers and disease-prone MRI regions are assessed for CSF proteins levels and brain structural changes. RESULTS: VILIP-1 and SNAP-25 displayed within-person increments in early symptomatic, amyloid-positive groups. CSF amyloid-positive (Aß+) subjects showed elevated baseline levels of total tau (tTau), phospho-tau181 (pTau), VILIP-1, and NG. YKL-40, SNAP-25, and NG are positively intercorrelated. Aß+ subjects showed negative MRI biomarker changes. YKL-40, tTau, pTau, and VILIP-1 are longitudinally associated with MRI biomarkers atrophy. DISCUSSION: Converters (CNc, MCIc) highlight the evolution of biomarkers during the disease progression. Results show that underlying amyloid pathology is associated with accelerated cognitive impairment. CSF levels of Aß42, pTau, tTau, VILIP-1, and SNAP-25 show utility to discriminate between mild cognitive impairment (MCI) converter and control subjects (CN). Higher levels of YKL-40 in the Aß+ group were longitudinally associated with declines in temporal pole and entorhinal thickness. Increased levels of tTau, pTau, and VILIP-1 in the Aß+ groups were longitudinally associated with declines in hippocampal volume. These CSF biomarkers should be used in assessing the characterization of the AD progression.

Dynamics and Distant Effects of Frontal/Temporal Epileptogenic Focus Using Functional Connectivity Maps.

OBJECTIVE: Connectivity patterns of interictal epileptiform discharges are all subtle indicators of where the three-dimensional (3D) source of a seizure could be located. These specific patterns are explored in the recorded electroencephalogram (EEG) signals of 20 individuals diagnosed with focal epilepsy to assess how their functional brain maps could be affected by the 3D onset of a seizure. METHODS: Functional connectivity maps, estimated by phase synchrony among EEG electrodes, were obtained by applying a data-driven recurrence-based method. This is augmented through a novel approach for selecting optimal parameters that produce connectivity matrices that are deemed significant for assessing epileptiform activity in context to the 3D source localization of seizure onset. These functional connectivity matrices were evaluated in different brain areas to gauge the regional effects of the 3D epileptic source. RESULTS: Empirical evaluations indicate high synchronization in the temporal and frontal areas of the effected epileptic hemisphere, whereas strong links connect the irritated area to frontal and temporal lobes of the opposite hemisphere. CONCLUSION: Epileptic activity originating in the temporal or frontal areas is seen to affect these areas in both hemispheres. SIGNIFICANCE: The results obtained express the dynamics of focal epilepsy in context to both the epileptogenic zone and the affected distant areas of the brain.

A Gaussian-based model for early detection of mild cognitive impairment using multimodal neuroimaging.

BACKGROUND: Diagnosis of early mild cognitive impairment (EMCI) as a prodromal stage of Alzheimer's disease (AD) with its delineation from the cognitively normal (CN) group remains a challenging but essential step for the planning of early treatment. Although several studies have focused on the MCI diagnosis, this study introduces the early stage of MCI to assess more thoroughly the earliest signs of disease manifestation and progression. NEW METHOD: We used random forest feature selection model with a Gaussian-based algorithm to perform method evaluation. This integrated method serves to define multivariate normal distributions in order to classify different stages of AD, with the focus placed on detecting EMCI subjects in the most challenging classification of CN vs. EMCI. RESULTS: Using 896 participants classified into the four categories of CN, EMCI, late mild cognitive impairment (LMCI) and AD, the results show that the EMCI group can be delineated from the CN group with a relatively high accuracy of 78.8% and sensitivity of 81.3%. COMPARISON WITH EXISTING METHOD(S): The feature selection model and classifier are compared with some other prominent algorithms. Although higher accuracy has been achieved using the Gaussian process (GP) model (78.8%) over the SVM classifier (75.6%) for CN vs. EMCI classification, with 0.05 being the cutoff for significance, and based on student's t-test, it was determined that the differences for accuracy, sensitivity, specificity between the GP method and support vector machine (SVM) are not statistically significant. CONCLUSION: Addressing the challenging classification of CN vs. EMCI provides useful information to help clinicians and researchers determine essential measures that can help in the early detection of AD.

A distributed multitask multimodal approach for the prediction of Alzheimer's disease in a longitudinal study.

Predicting the progression of Alzheimer's Disease (AD) has been held back for decades due to the lack of sufficient longitudinal data required for the development of novel machine learning algorithms. This study proposes a novel machine learning algorithm for predicting the progression of Alzheimer's disease using a distributed multimodal, multitask learning method. More specifically, each individual task is defined as a regression model, which predicts cognitive scores at a single time point. Since the prediction tasks for multiple intervals are related to each other in chronological order, multitask regression models have been developed to track the relationship between subsequent tasks. Furthermore, since subjects have various combinations of recording modalities together with other genetic, neuropsychological and demographic risk factors, special attention is given to the fact that each modality may experience a specific sparsity pattern. The model is hence generalized by exploiting multiple individual multitask regression coefficient matrices for each modality. The outcome for each independent modality-specific learner is then integrated with complementary information, known as risk factor parameters, revealing the most prevalent trends of the multimodal data. This new feature space is then used as input to the gradient boosting kernel in search for a more accurate prediction. This proposed model not only captures the complex relationships between the different feature representations, but it also ignores any unrelated information which might skew the regression coefficients. Comparative assessments are made between the performance of the proposed method with several other well-established methods using different multimodal platforms. The results indicate that by capturing the interrelatedness between the different modalities and extracting only relevant information in the data, even in an incomplete longitudinal dataset, will yield minimized prediction errors.

Gaussian Discriminant Analysis for Optimal Delineation of Mild Cognitive Impairment in Alzheimer's Disease.

Over the past few years, several approaches have been proposed to assist in the early diagnosis of Alzheimer's disease (AD) and its prodromal stage of mild cognitive impairment (MCI). Using multimodal biomarkers for this high-dimensional classification problem, the widely used algorithms include Support Vector Machines (SVM), Sparse Representation-based classification (SRC), Deep Belief Networks (DBN) and Random Forest (RF). These widely used algorithms continue to yield unsatisfactory performance for delineating the MCI participants from the cognitively normal control (CN) group. A novel Gaussian discriminant analysis-based algorithm is thus introduced to achieve a more effective and accurate classification performance than the aforementioned state-of-the-art algorithms. This study makes use of magnetic resonance imaging (MRI) data uniquely as input to two separate high-dimensional decision spaces that reflect the structural measures of the two brain hemispheres. The data used include 190 CN, 305 MCI and 133 AD subjects as part of the AD Big Data DREAM Challenge #1. Using 80% data for a 10-fold cross-validation, the proposed algorithm achieved an average F1 score of 95.89% and an accuracy of 96.54% for discriminating AD from CN; and more importantly, an average F1 score of 92.08% and an accuracy of 90.26% for discriminating MCI from CN. Then, a true test was implemented on the remaining 20% held-out test data. For discriminating MCI from CN, an accuracy of 80.61%, a sensitivity of 81.97% and a specificity of 78.38% were obtained. These results show significant improvement over existing algorithms for discriminating the subtle differences between MCI participants and the CN group.

Off-line and on-line stress detection through processing of the pupil diameter signal.

The pupil diameter (PD), controlled by the autonomic nervous system, seems to provide a strong indication of affective arousal, as found by previous research, but it has not been investigated fully yet. In this study, new approaches based on monitoring and processing the PD signal for off-line and on-line "relaxation" vs. "stress" differentiation are proposed. For the off-line approach, wavelet denoising, Kalman filtering, data normalization, and feature extraction are sequentially utilized. For the on-line approach, a hard threshold, a moving average window and three stress detection steps are implemented. In order to use only the most reliable data, two types of data selection methods (paired t test based on galvanic skin response (GSR) data and subject self-evaluation) are applied, achieving average classification accuracies up to 86.43 and 87.20% for off-line and 72.30 and 73.55% for on-line algorithms, with each set of selected data, respectively. The GSR was also monitored and processed in our experiments for comparison purposes, with the highest classification rate achieved being only 63.57% (based on the off-line processing algorithm). The overall results show that the PD signal is more effective and robust for differentiating "relaxation" vs. "stress," in comparison with the traditionally used GSR signal.

Contrast improvement in pre-compensation of ocular aberrations for computer users.

Ocular aberrations in the human eye prevent many users from interacting efficiently with Graphic User Interfaces in computers. While traditionally these aberrations are corrected by external means (e.g., spectacles, refractive surgery), there have been approaches to address them by custom pre-compensation of the displayed images, based on the characterization of the eye’s aberrations. However, the limited intensity levels of display devices reduce the contrast perceived by the user when viewing the pre-compensated images. This paper proposes a histogram side-trim correction method for the pre-compensated images that seeks to reduce the contrast loss perceived by the viewer. The proposed histogram trimming process is designed to be automatic, not requiring manual intervention. Experiments are performed using a high-resolution camera as an “artificial eye”, to evaluate the efficiency of the histogram side-trim method in improving the contrast of perceived images. Results show that the side-trim method improved the contrast of images perceived by the “artificial eye”.

Comparison of the use of pupil diameter and galvanic skin response signals for affective assessment of computer users.

The implementation of Affective Computing concepts requires the assessment of the affective states in the computer user, e.g., “relaxation” or “stress”. Traditionally, the Galvanic Skin Response (GSR) signal has been analyzed as the leading indicator of the sympathetic activation that accompanies “stress”, when it is experienced by a computer user. However, recent research has found that the Pupil Diameter (PD), which is also controlled by the Autonomic Nervous System (ANS), can be an important indicator of sympathetic activation. This paper describes techniques for the processing of the Pupil Diameter (PD) signal to detect episodes of mental stress induced in experimental subjects, differentiating them from “relaxation” intervals. Our experiments also recorded and analyzed the GSR signal from the subjects, for comparison purposes. The PD signal is first pre-processed applying wavelet denoising and Kalman filtering to remove the high-frequency variations of the raw PD signal that are not representative of the subject’s affective state. Then 3 features are extracted from the normalized, pre-processed PD signal and five different classification algorithms are applied on these features to differentiate the states of “relaxation” vs. “stress” in the computer user. Similarly, 3 GSR features were obtained and used for classification. PD-based classification achieved an average accuracy of 85.86%. GSR-based classification achieved an average accuracy of 60.66%. Therefore, the results indicate that the pupil diameter may be one of the most significant physiological signals to monitor for affective assessment and differentiation of “relaxation” vs. “stress” states of a computer user.

A 3-D liver segmentation method with parallel computing for selective internal radiation therapy.

This study describes a new 3-D liver segmentation method in support of the selective internal radiation treatment as a treatment for liver tumors. This 3-D segmentation is based on coupling a modified k-means segmentation method with a special localized contouring algorithm. In the segmentation process, five separate regions are identified on the computerized tomography image frames. The merit of the proposed method lays in its potential to provide fast and accurate liver segmentation and 3-D rendering as well as in delineating tumor region(s), all with minimal user interaction. Leveraging of multicore platforms is shown to speed up the processing of medical images considerably, making this method more suitable in clinical settings. Experiments were performed to assess the effect of parallelization using up to 442 slices. Empirical results, using a single workstation, show a reduction in processing time from 4.5 h to almost 1 h for a 78% gain. Most important is the accuracy achieved in estimating the volumes of the liver and tumor region(s), yielding an average error of less than 2% in volume estimation over volumes generated on the basis of the current manually guided segmentation processes. Results were assessed using the analysis of variance statistical analysis.

Dynamic image pre-compensation for computer access by individuals with ocular aberrations.

Several image enhancement methods have been successfully used to improve the visual perception of patients with eye diseases, such as Age-related Macular Degeneration and Cataracts, on images displayed on TV and computers. However, few developments aim to enhance the visual performance of computer users with general ocular aberrations. This paper proposes an image enhancement approach based on dynamic pre-compensation for improving the visual performance of subjects with ocular aberrations, while interacting with computers. The degradation caused by ocular aberrations is counteracted through the pre-compensation performed on images displayed on the computer screen. As the ocular aberration initially measured as a priori information is related with a specific pupil size, real-time pupil size data are collected to recalculate and update the pre-compensation to match the corresponding aberrations. An icon recognition experiment, involving human subjects, was designed and implemented to evaluate the performance of the proposed method. The experimental results show that the proposed method significantly increased the number of icons correctly recognized, which confirmed that the dynamic pre-compensation is effective in improving the visual performance of computer users with ocular aberrations.

Sub-patterns of language network reorganization in pediatric localization related epilepsy: a multisite study.

To study the neural networks reorganization in pediatric epilepsy, a consortium of imaging centers was established to collect functional imaging data. Common paradigms and similar acquisition parameters were used. We studied 122 children (64 control and 58 LRE patients) across five sites using EPI BOLD fMRI and an auditory description decision task. After normalization to the MNI atlas, activation maps generated by FSL were separated into three sub-groups using a distance method in the principal component analysis (PCA)-based decisional space. Three activation patterns were identified: (1) the typical distributed network expected for task in left inferior frontal gyrus (Broca's) and along left superior temporal gyrus (Wernicke's) (60 controls, 35 patients); (2) a variant left dominant pattern with greater activation in IFG, mesial left frontal lobe, and right cerebellum (three controls, 15 patients); and (3) activation in the right counterparts of the first pattern in Broca's area (one control, eight patients). Patients were over represented in Groups 2 and 3 (P < 0.0004). There were no scanner (P = 0.4) or site effects (P = 0.6). Our data-driven method for fMRI activation pattern separation is independent of a priori notions and bias inherent in region of interest and visual analyses. In addition to the anticipated atypical right dominant activation pattern, a sub-pattern was identified that involved intensity and extent differences of activation within the distributed left hemisphere language processing network. These findings suggest a different, perhaps less efficient, cognitive strategy for LRE group to perform the task.

Affective assessment of computer users based on processing the pupil diameter signal.

Detecting affective changes of computer users is a current challenge in human-computer interaction which is being addressed with the help of biomedical engineering concepts. This article presents a new approach to recognize the affective state ("relaxation" vs. "stress") of a computer user from analysis of his/her pupil diameter variations caused by sympathetic activation. Wavelet denoising and Kalman filtering methods are first used to remove abrupt changes in the raw Pupil Diameter (PD) signal. Then three features are extracted from the preprocessed PD signal for the affective state classification. Finally, a random tree classifier is implemented, achieving an accuracy of 86.78%. In these experiments the Eye Blink Frequency (EBF), is also recorded and used for affective state classification, but the results show that the PD is a more promising physiological signal for affective assessment.

Vision correction for computer users based on image pre-compensation with changing pupil size.

Many computer users suffer varying degrees of visual impairment, which hinder their interaction with computers. In contrast with available methods of vision correction (spectacles, contact lenses, LASIK, etc.), this paper proposes a vision correction method for computer users based on image pre-compensation. The blurring caused by visual aberration is counteracted through the pre-compensation performed on images displayed on the computer screen. The pre-compensation model used is based on the visual aberration of the user's eye, which can be measured by a wavefront analyzer. However, the aberration measured is associated with one specific pupil size. If the pupil has a different size during viewing of the pre-compensated images, the pre-compensation model should also be modified to sustain appropriate performance. In order to solve this problem, an adjustment of the wavefront function used for pre-compensation is implemented to match the viewing pupil size. The efficiency of these adjustments is evaluated with an "artificial eye" (high resolution camera). Results indicate that the adjustment used is successful and significantly improves the images perceived and recorded by the artificial eye.

A spreadsheet application for processing long-term EEG recordings.

This study develops a Windows application for processing huge tabular text files. The tool has been especially designed for handling EEG files. As a consequence, tables with more than 65,536 rows and 256 columns, which is a limitation found in Microsoft's Excel, can be loaded, visualized and processed with no more restrictions than the ones imposed by the memory of the operating system. Beyond tabular visualization, additional tools are available for chart customization and spreadsheet like cell processing commands. Additionally, commands are included for signal processing, cluster analysis and computationally taxing matrix algebra operations.

Classification of electroencephalographic seizure recordings into ictal and interictal files using correlation sum.

This study provides a performance evaluation of the correlation sum in terms of accuracy, sensitivity, and specificity in its ability to classify seizure files from non-seizure files. The main thrust of the study is whether computable properties ("metrics") of EEG tracings over time allow a seizure to be detected. This study evaluates raw intracranial EEG (iEEG) recordings with the intent to detect a seizure and classify different EEG epoch files. One hundred twenty-six iEEG files from eleven sequential patients are processed and the correlation sum is extracted from non-overlapping scrolling windows of 1-s duration. The novelty of this research is in defining a generalized nonlinear approach to classify EEG seizure segments by introducing nonlinear decision functions with the flexibility in choosing any degree of complexity and with any number of dimensions, lending resiliency to data overlap and opportunity for multidimensional data analysis. A singular contribution of this work is in determining a 2-D decision plane, in this case, where duration is one dimension and window-based minima of the correlation sum is the second dimension. Also, experimental observations clearly indicate that a significant drop in the magnitude of the correlation sum signal actually coincides with the clinical seizure onset more so than the electrographic seizure onset as provided by the medical experts. The method with k-fold cross validation performed with an accuracy of 91.84%, sensitivity of 92.31%, and specificity of 91.67%, which makes this classification method most suitable for offline seizure detection applications.

H-infinity time-varying adaptive filtering of pupil diameter for affective sensing - biomed 2009.

Recently, it has been confirmed that the diameter of the human pupil, which is controlled by the Autonomic Nervous System (ANS), responds to cognitive and emotional processes. However, it is also well known that the dominant factor in determining pupil diameter (PD) is the pupillary light reflex (PLR), which decreases the pupil size as larger amounts of light are sensed by the retina. In this study, we attempt to minimize the PLR-driven PD changes in the PD signal measured during human-computer interaction, through an Adaptive Interference Canceller (AIC), with the H8 time-varying (HITV) adaptive algorithm, so that the output of the AIC, the Modified Pupil Diameter (MPD), can be used to estimate the affective changes of a computer user. The results of this study confirm that the AIC with the HITV adaptive algorithm is able to minimize the PD changes caused by PLR to an acceptable level, which will allow the monitoring of affective changes in a computer user through the resulting MPD signal.