Long-lasting negativity in the left motoric brain structures during word memory inhibition in the Think/No-Think paradigm.

In this study, we investigated the electrical brain responses in a high-density EEG array (64 electrodes) elicited specifically by the word memory cue in the Think/No-Think paradigm in 46 participants. In a first step, we corroborated previous findings demonstrating sustained and reduced brain electrical frontal and parietal late potentials elicited by memory cues following the No-Think (NT) instructions as compared to the Think (T) instructions. The topographical analysis revealed that such reduction was significant 1000 ms after memory cue onset and that it was long-lasting for 1000 ms. In a second step, we estimated the underlying brain generators with a distributed method (swLORETA) which does not preconceive any localization in the gray matter. This method revealed that the cognitive process related to the inhibition of memory retrieval involved classical motoric cerebral structures with the left primary motor cortex (M1, BA4), thalamus, and premotor cortex (BA6). Also, the right frontal-polar cortex was involved in the T condition which we interpreted as an indication of its role in the maintaining of a cognitive set during remembering, by the selection of one cognitive mode of processing, Think, over the other, No-Think, across extended periods of time, as it might be necessary for the successful execution of the Think/No-Think task.

Developing psychoanalytic case conceptualization skills through didactic teaching: A randomized controlled trial.

OBJECTIVE: Time-limited didactic interventions have been shown to be effective in developing "generic" case conceptualization skills. The objective of this study is to test whether similar interventions can be used to develop case conceptualization skills that are "specific" to a treatment modality. METHOD: University psychology students were randomized to a target (n = 62) or a control group (n = 62). The target group received a training on psychoanalytic case conceptualization skills based on the newly-developed operators model. The control group received a training on generic case conceptualization skills based on the well-established 5 Ps model. RESULTS: The students' self-efficacy for case conceptualization significantly increased in both groups. However, students in the target group reported a significantly greater increase in psychoanalytic case conceptualization skills and in their ability to make clinical inferences. The teaching method, as well as the case conceptualization models, were acceptable to students. However, the 5 Ps model was significantly more acceptable to students than the operators model. CONCLUSIONS: This is the first RCT to provide evidence that psychoanalytic case conceptualization skills can be developed through didactic teaching and that they constitute a specific set of skills that are not developed by learning generic case conceptualization skills.

Running away from phonological ambiguity, we stumble upon our words: Laboratory induced slips show differences between highly and lowly defensive people.

Introduction: Freud proposed that slips of the tongue, including apparently simple ones, always have a sense and constitute « a half-success and a half-failure ¼ compromise resulting from defensive mechanisms. Material and methods: A total of 55 subjects participated in a French adaptation of the Spoonerisms of Laboratory Induced Predisposition or SLIP-technique including 32 "neutral" and 32 taboo spoonerisms and measures of defensiveness. In accordance with a psychoanalytical and empirically supported distinction, we considered two kinds of defenses: elaborative or primary process and inhibitory or secondary process defenses, which were operationalized with the GeoCat and the Phonological-Nothing (PN) WordList, respectively. The GeoCat is a validated measure of primary process mentation and the PN WordList was shown to measure the defensive avoidance of language ambiguity. Results: Participants produced 37 slips, with no significant difference in the number of "neutral" and taboo slips. The GeoCat and the N/PN parameters explained 30% of the variance in the production of parapraxes, confirming the defensive logics of slips. When dividing the population into lowly and highly defensive participants (with the Marlowe Crowne Social Desirability scale), primary process mentation appears as a baseline default defense, but only highly defensive participants mobilize an additional inhibitory secondary process type of defense. Taking into account the a priori difference between taboo and "neutral" parapraxes, highly defensive participants made 2.7 times more taboo parapraxes than lowly defensive participants. However, if "neutral" parapraxes in both subgroups followed the same logic as the total group of parapraxes (significant contribution of primary process mentation in lowly defensives and of primary and secondary process mentation in highly defensives), these measures had no contribution to explain the occurrence of taboo parapraxes. Conclusion: We propose that Motley et al.'s prearticulatory editor, ensuring the censorship over taboo parapraxes, is an external instance of inhibition, proximal to uttering, equivalent to the censorship between the systems Preconscious and Conscious in Freud's metapsychology. By contrast, the defenses measured in this research are internal, intimate control systems, probing for the censorship between the systems Unconscious and Preconscious, this is, for repression. This study contributes to support a psychodynamic explanatory model for the production of parapraxes.

People solve rebuses unwittingly-Both forward and backward: Empirical evidence for the mental effectiveness of the signifier.

Introduction: Freud proposed that names of clinically salient objects or situations, such as for example a beetle (Käfer) in Mr. E's panic attack, refer through their phonological word form, and not through their meaning, to etiologically important events-here, "Que faire?" which summarizes the indecisiveness of Mr. E's mother concerning her marriage with Mr. E's father. Lacan formalized these ideas, attributing full-fledged mental effectiveness to the signifier, and summarized this as "the unconscious structured as a language". We tested one aspect of this theory, namely that there is an influence of the ambiguous phonological translation of the world upon our mental processing without us being aware of this influence. Methods: For this, we used a rebus priming paradigm, including 14 French rebuses, composed of two images depicting common objects, such as paon /pã/ "peacock" and terre /tεr/ "earth," together forming the rebus panthère /pãtεr/ "panther." These images were followed by a target word semantically related to the rebus resolution, e.g., félin "feline," upon which the participants, unaware of the rebus principle, produced 6 written associations. A total of 1,458 participants were randomly assigned either to Experiment 1 in which they were shown the rebus images in either forward or in reverse order or to Experiment 2, in which they were shown only one of both rebus images, either the first or the last. Results and discussion: The results show that the images induced inadvertent rebus priming in naïve participants. In other words, our results show that people solve rebuses unwittingly independent of stimulus order, thereby constituting empirical evidence for the mental effectiveness of the signifier.

Eyes Wide Shut: Primary Process Opens Up.

Freud was the first to invite his patients to lie down on a couch, facilitating the closing of the eyes. If the mere fact of closing the eyes favors access to unconscious materials, it should also favor primary process mentation. Primary process is an associative mode of thought based on superficial similarities including phonology, while secondary process mentation in language is primarily concerned with meaning. Fifty-two participants were given French Word Lists with phonological choices (P) corresponding to primary processes, while semantic choices (S) represent secondary processes when they are in mutual competition (PS). For example, participants were given a first word, such as, e.g. cale (to hold), and then had to choose between lac (P; lake) and fixe (S; fix), which alternative was most similar to the first word, cale. Two control lists, SN and PN, where the other choice is unrelated (N for nothing), verify that the subjects are equally capable of recognizing the phonological and semantics similarity. Results show an (near 10% increase in P choices in PS when participants close their eyes, while results on PN and SN were unchanged. The mere fact of closing the eyes induces a modest increase in primary process mentation. Based on the literature, the eyes closed (EC) condition is linked to increased alpha synchronization, which is thought to induce an inward mental shift. This research contributes to validating the psychoanalytic technique consisting on inviting patients to lie down on a couch and invite them to close their eyes.

Phonological Ambiguity Detection Outside of Consciousness and Its Defensive Avoidance.

Freud proposes that in unconscious processing, logical connections are also (heavily) based upon phonological similarities. Repressed concerns, for example, would also be expressed by way of phonologic ambiguity. In order to investigate a possible unconscious influence of phonological similarity, 31 participants were submitted to a tachistoscopic subliminal priming experiment, with prime and target presented at 1 ms. In the experimental condition, the prime and one of the 2 targets were phonological reversed forms of each other, though graphemically dissimilar (e.g., "nice" and "sign"); in the control condition the targets were pseudo-randomly attributed to primes to which they don't belong. The experimental task was to "blindly" pick the choice most similar to the prime. ERPs were measured with a focus on the N320, which is known to react selectively to phonological mismatch in supraliminal visual word presentations. The N320 amplitude-effects at the electrodes on the midline and at the left of the brain significantly predicted the participants' net behavioral choices more than half a second later, while their subjective experience is one of arbitrariness. Moreover, the social desirability score (SDS) significantly correlates with both the behavioral and the N320 brain responses of the participants. It is proposed that in participants with low SDS the phonological target induces an expected reduction of N320 and this increases their probability to pick this target. In contrast, high defensive participants have a perplexed brain reaction upon the phonological target, with a negatively peaking N320 as compared to control and this leads them to avoid this target more often. Social desirability, which is understood as reflecting defensiveness, might also manifest itself as a defense against the (energy-consuming) ambiguity of language. The specificity of this study is that all of this is happening totally out of awareness and at the level of very elementary linguistic distinctions.

Processing of a Subliminal Rebus during Sleep: Idiosyncratic Primary versus Secondary Process Associations upon Awakening from REM- versus Non-REM-Sleep.

Primary and secondary processes are the foundational axes of the Freudian mental apparatus: one horizontally as a tendency to associate, the primary process, and one vertically as the ability for perspective taking, the secondary process. Primary process mentation is not only supposed to be dominant in the unconscious but also, for example, in dreams. The present study tests the hypothesis that the mental activity during REM-sleep has more characteristics of the primary process, while during non-REM-sleep more secondary process operations take place. Because the solving of a rebus requires the ability to non-contexually condensate the literal reading of single stimuli into a new one, rebus solving is a primary process operation by excellence. In a replication of the dream-rebus study of Shevrin and Fisher (1967), a rebus, which consisted of an image of a comb (German: "Kamm") and an image of a raft (German: "Floß"), resulting in the German rebus word "kampflos" (Engl.: without a struggle), was flashed subliminally (at 1 ms) to 20 participants before going to sleep. Upon consecutive awakenings participants were asked for a dream report, free associations and an image description. Based on objective association norms, there were significantly more conceptual associations referring to Kamm and Floß indexing secondary process mentation when subjects were awakened from non-REM sleep as compared to REM-awakenings. There were not significantly more rebus associations referring to kampflos indexing primary process mentation when awakened from REM-sleep as compared to non-REM awakenings. However, when the associations were scored on the basis of each subject's individual norms, there was a rebus effect with more idiosyncratic rebus associations in awakenings after REM than after non-REM-sleep. Our results support the general idea that REM-sleep is characterized by primary process thinking, while non-REM-sleep mentation follows the rules of the secondary process.

A smoking-related background helps moderate smokers to focus: An event-related potential study using a Go-NoGo task.

OBJECTIVE: Cognitive impairment is a major component in addiction. However, research has been inconclusive as to whether this is also the case for smokers. The present study aims at providing electrophysiological clue for altered inhibitory control in smokers and at investigating whether reduced inhibition was more pronounced during exposure to a smoking cue. METHODS: ERPs were recorded during a visual Go-NoGo task performed by 18 smokers and 23 controls, in which either a frequent Go signal (letter "M") or a rare No-Go signal ("letter W") were superimposed on three different long-lasting background contexts: black-neutral, smoking-related and non smoking-related. RESULTS: (1) Smokers performed worse and had an earlier NoGo-N2 latency as compared to controls and independently of context, suggesting a general inhibition impairment; (2) with smoking-related backgrounds specifically, smokers made fewer mistakes than they did in other contexts and displayed a larger NoGo P3 amplitude. CONCLUSION: These data might suggest that background cues related to addiction may help smokers to be more accurate in an inhibition task. SIGNIFICANCE: Our results show the classical inhibitory impairment in smokers as compared to non-smokers. However, our data also suggest that a smoking-related background may bolster the inhibitory ability of smokers specifically.

Smoking addiction: the shift from head to hands: Approach bias towards smoking-related cues in low-dependent versus dependent smokers.

The dual process theory is central to several models of addiction, implying both an increase of stimulus salience and deficits in inhibitory control. Our major aim is to provide behavioral evidence for an approach bias tendency in smokers and more specifically during smoking cue exposure. The second aim is to examine whether this bias differs in low-dependent versus dependent smokers. Thirty-two smokers (17 low dependent and 15 dependent; cut-off FTND of 4) and 28 non-smokers performed a modified Go/NoGo task using tobacco-related words and neutral words as stimuli. Smokers generally made more mistakes and tended to be faster for smoking-related cues specifically. Low dependents acknowledged more their dependency in declarative questionnaires while making more errors and being slower specifically on smoking cues; dependent smokers were less prone to indicate their addiction, but were faster and accurate when it came to picking the smoking cues. These results suggest that a shift has operated from a mental preoccupation with smoking in the low-dependent group, to smoking as a motor habit in our dependent group. This finding invites experts to rethink smoking addiction in the light of this crucial moment, namely, the shift "from head to hands".

Alpha synchronization as a brain model for unconscious defense: An overview of the work of Howard Shevrin and his team.

Howard Shevrin and his team have developed a stringent subliminal priming methodology, which experimentally approximates a situation of an internal, mental triggering of unconscious defense. Through a series of four studies they thus are able to bring evidence for this type of unconscious defense. With event-related potentials, three clinical studies show how synchronization of a specific brain wave, the alpha wave, known for its inhibitory function, is also induced by subliminally presented conflictual subject-specific stimuli. Therefore, alpha synchronization could serve as the brain mechanism of unconscious defense. The results only make sense if we suppose the existence of a dynamic unconscious, which has inherited childhood conflicts, and with privileged connections to neurotic symptom characteristics. Moreover, by showing that the unconscious conflict phrases, inferred by clinicians from clinical interviews, have a similar brain behavior, Shevrin and his team provide evidence that these inferences are not simply clinician-dependent subjective interpretations but also imply some form of independent mental reality. Finally, interpretation of the results has led us to propose two distinct physiological mechanisms for defense: one, unconscious defense, by alpha synchronization in connection with the drive derivatives, and another, repression, based on the indications of reality in connection with the ego.

A French Translation of the Pleasure Arousal Dominance (PAD) Semantic Differential Scale for the Measure of Affect and Drive.

Multivariate studies have repeatedly confirmed that three basic dimensions of human emotional behavior, called pleasure (P), arousal (A) and dominance (D) are persistent in organizing human judgments for a wide range of perceptual and symbolic stimuli. The Mehrabian and Russell's PAD semantic differential scale is a well-established tool to measure these categories, but no standardized French translation is available for research. The aim of this study was to validate a French version of the PAD. For this purpose, (1) Mehrabian and Russell's PAD was translated through a process of translations and back-translations and (2) this French PAD was tested in a population of 111 French-speaking adults on 21 images of the International Affective Picture System (IAPS). A confirmatory factor analysis revealed the expected three-factor structure; the French PAD also distributed the images in the affective space according to the expected boomerang-shape. The present version of PAD is thus a valid French translation of Mehrabian and Russell's original PAD.

The Mark, the Thing, and the Object: On What Commands Repetition in Freud and Lacan.

In Logique du Fantasme, Lacan argues that the compulsion to repeat does not obey the same discharge logic as homeostatic processes. Repetition installs a realm that is categorically different from the one related to homeostatic pleasure seeking, a properly subjective one, one in which the mark "stands for," "takes the place of," what we have ventured to call "an event," and what only in the movement of return, in what Lacan calls a "thinking of repetition," confirms and ever reconfirms this point of no return, which is also a qualitative cut and a structural loss. The kind of "standing for" Lacan intends here with the concept of repetition is certainly not something like an image or a faithful description. No, what Lacan wishes to stress is that this mark is situated at another level, at another place, it is "entstellt," and as such, it is punctually impinging upon the bodily dynamics without rendering the event, without having an external meta-point of view, but cutting across registers according to a logics that is not the homeostatic memory logics. This paper elaborates on this distinction on the basis of a confrontation with what Freud says about the pleasure principle and its beyond in Beyond the Pleasure Principle, and also takes inspiration from Freud's Project for a Scientific Psychology. We argue that Lacan's theory of enjoyment takes up and generalizes what Freud was after in Beyond the Pleasure Principle with the Wiederholungszwang, and pushes Freud's thoughts to a more articulated point: to the point where a subject is considered to speak only when it has allowed the other, through discourse, to have impacted and cut into his bodily pleasure dynamics.

On the physiology of jouissance: interpreting the mesolimbic dopaminergic reward functions from a psychoanalytic perspective.

Jouissance is a Lacanian concept, infamous for being impervious to understanding and which expresses the paradoxical satisfaction that a subject may derive from his symptom. On the basis of Freud's "experience of satisfaction" we have proposed a first working definition of jouissance as the (benefit gained from) the motor tension underlying the action which was [once] adequate in bringing relief to the drive and, on the basis of their striking reciprocal resonances, we have proposed that central dopaminergic systems could embody the physiological architecture of Freud's concept of the drive. We have then distinguished two constitutive axes to jouissance: one concerns the subject's body and the other the subject's history. Four distinctive aspects of these axes are discussed both from a metapsychological and from a neuroscience point of view. We conclude that jouissance could be described as an accumulation of body tension, fuelling for action, but continuously balancing between reward and anxiety, and both marking the physiology of the body with the history of its commemoration and arising from this inscription as a constant push to act and to repeat. Moreover, it seems that the mesolimbic accumbens dopaminergic pathway is a reasonable candidate for its underlying physiological architecture.

Subliminal unconscious conflict alpha power inhibits supraliminal conscious symptom experience.

Our approach is based on a tri-partite method of integrating psychodynamic hypotheses, cognitive subliminal processes, and psychophysiological alpha power measures. We present ten social phobic subjects with three individually selected groups of words representing unconscious conflict, conscious symptom experience, and Osgood Semantic negative valence words used as a control word group. The unconscious conflict and conscious symptom words, presented subliminally and supraliminally, act as primes preceding the conscious symptom and control words presented as supraliminal targets. With alpha power as a marker of inhibitory brain activity, we show that unconscious conflict primes, only when presented subliminally, have a unique inhibitory effect on conscious symptom targets. This effect is absent when the unconscious conflict primes are presented supraliminally, or when the target is the control words. Unconscious conflict prime effects were found to correlate with a measure of repressiveness in a similar previous study (Shevrin et al., 1992, 1996). Conscious symptom primes have no inhibitory effect when presented subliminally. Inhibitory effects with conscious symptom primes are present, but only when the primes are supraliminal, and they did not correlate with repressiveness in a previous study (Shevrin et al., 1992, 1996). We conclude that while the inhibition following supraliminal conscious symptom primes is due to conscious threat bias, the inhibition following subliminal unconscious conflict primes provides a neurological blueprint for dynamic repression: it is only activated subliminally by an individual's unconscious conflict and has an inhibitory effect specific only to the conscious symptom. These novel findings constitute neuroscientific evidence for the psychoanalytic concepts of unconscious conflict and repression, while extending neuroscience theory and methods into the realm of personal, psychological meaning.

De lo que se inscribe y no se borra: pequeña fisiología de la represión y del goce / On what is inscribed and not erased: short physiology of repression and enjoyment

El presente trabajo se centra en la relación existente entre el psicoanálisis y las neurociencias. El trabajo comienza con una referencia a los conceptos de sensación y percepción así como al de activación motora que resulta de la información consiguiente, para presentar una visión de los conceptos de representación y represión. A continuación, los autores proponen un modelo de la pulsión que incluye concepciones de Freud y de Lacan y luego se explayan en los sistemas fisiológicos subyacentes al placer y al goce de este modelo. Los autores sostienen que el lenguaje, al permitir trazar la huella de la historia personal, otorga al goce una forma precisa que permite, a veces, volver a trazar esa historia. Para terminar, a modo de ejemplo, ilustran esta postura mediante una viñeta clínica.

From sensorimotor inhibition to freudian repression: insights from psychosis applied to neurosis.

First, three case studies are presented of psychotic patients having in common an inability to hold something down or out. In line with other theories on psychosis, we propose that a key change is at the efference copy system. Going back to Freud's mental apparatus, we propose that the messages of discharge of the motor neurons, mobilized to direct perception, also called "indications of reality," are equivalent to the modern efference copies. With this key, the reading of the cases is coherent with the psychodynamic understanding of psychosis, being a downplay of secondary processes, and consequently, a dominance of primary processes. Moreover, putting together the sensorimotor idea of a failure of efference copy-mediated inhibition with the psychoanalytic idea of a failing repression in psychosis, the hypothesis emerges that the attenuation enabled by the efference copy dynamics is, in some instances, the physiological instantiation of repression. Second, we applied this idea to the mental organization in neurosis. Indeed, the efference copy-mediated attenuation is thought to be the mechanism through which sustained activation of an intention, without reaching it - i.e., inhibition of an action - gives rise to mental imagery. Therefore, as inhibition is needed for any targeted action or for normal language understanding, acting in the world, or processing language, structurally induces mental imagery, constituting a subjective unconscious mental reality. Repression is a special instance of inhibition for emotionally threatening stimuli. These stimuli require stronger inhibition, leaving (the attenuation of) the motor intentions totally unanswered, in order to radically prevent execution which would lead to development of excess affect. This inhibition, then, yields a specific type of motor imagery, called "phantoms," which induce mental preoccupation, as well as symptoms which, especially through their form, refer to the repressed motor fragments.