1.
Bioorg Med Chem Lett
; 21(3): 971-6, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21232953
RESUMO
A series of N-propyl-8-chloro-6-substituted isoquinolones was identified as positive allosteric modulators of metabotropic glutamate receptor 2 (mGluR2 PAM) via high throughput screening (HTS). The subsequent synthesis and initial SAR exploration that led to the identification of compound 28 is described.