All-fiber laser source at 1645 nm for lidar measurement of methane concentration and wind velocity.

We report on the realization of an all-fiber laser source that delivers single-frequency pulses at 1645 nm, on a linearly polarized single-mode beam, based on stimulated Raman scattering in passive fibers. The pulse energy reaches 14 µJ for a repetition rate of 20 kHz, and the spectral linewidth is 9.5 MHz for 100 ns square pulses. To the best of our knowledge, this energy is the highest reported at 1645 nm in an all-fiber laser source. Our method consists of reducing the stimulated Brillouin scattering (SBS) gain for the pump and signal pulses, respectively, by sweeping the optical frequency of the pump beam, and by applying a strain gradient on the amplification fiber. This compact laser source is now used in a transportable lidar system to measure simultaneously wind velocity and methane (CH4) concentration.

Radiological prevalence of osteoarthritis of the cervical region in 104 performing Warmblood jumpers.

BACKGROUND: Cervical osteoarthritis (OA) has been documented as a potential source of pain and poor performance in sport horses. OBJECTIVES: To assess the prevalence of cervical OA in a population of Warmblood jumpers and its correlation with age, level of performance, neck pain and mobility. STUDY DESIGN: Descriptive observational study. METHODS: Warmblood jumpers free of lameness or neurological disorders were selected. Cervical pain and range of motion of the neck were subjectively assessed. Left to right lateral views were taken at C3-C4, C4-C5, C5-C6 and C6-C7. The presence of OA at the cervical articular process joints (APJs) was evaluated and graded as absent, mild or moderate to severe by three board-certified radiologists. The agreement between radiologists and the potential associations between OA grades with age and other variables were statistically assessed (P < .05). RESULTS: One hundred and four horses were included [median age = 10 years (range 6-18 years)]. Agreement between radiologists varied from fair to substantial (Kappa-weighted 0.37-0.61). The C6-C7 APJ was most commonly affected by OA with only 32.7% of APJ considered free of radiographic abnormalities at this location versus 60.5% at C5-C6, 81.7% at C4-C5 and 84.6% at C3-C4. Horses competing in higher level classes (peak of performance) had significantly higher OA grades at C6-C7 (P = .013). There was no association between age, age when started jumping, neck pain and neck range of motion with the presence of OA on radiographs. MAIN LIMITATIONS: Open enrolment and lack of orthogonal views. CONCLUSIONS: This study showed that, although there is a range of interpretation of radiographic findings of the APJ, OA of the caudal cervical region is not rare in performing sound Warmblood jumpers. This suggests that OA in the caudal cervical region may be of low clinical significance.

What do adult outpatients included in clinical trials know about the investigational drugs being assessed: A cross-sectional study in France.

This study aimed to assess patient investigational medication knowledge and to identify factors associated with medication understanding by adult outpatients included in clinical trials. A cross-sectional prospectively designed survey was conducted on consecutive volunteers at 21 university teaching hospitals (in France) from February to December 2014. Investigational medication understanding was assessed at the time of the first dispensing using a structured interviewer-administered questionnaire based on information obtained from the literature that provided an 8-point score. Demographic and other baseline data were collected using structured interviews. Of the 236 participants, 139 (58.9%) of the respondents were male, and the median age was 54.9 years (range: 18-83 years). The mean understanding score was 6.24 and 72.5% of the patients had a score of 6 or higher. In univariate analysis, the medication understanding score was negatively correlated with age (r = -0.15, p = 0.0247) and positively correlated with the level of education (r = 0.25, p = 0.0002). In multivariate analysis, prognostic factors of a higher medication understanding score were: graduation from high school or a higher level of education; HIV infection; phase II/III/IV studies; mention of the drug on the prescription form, and the dispensing of a single investigational medication. Only a quarter of the adult outpatients included in clinical trials had a maximum possible investigational medication understanding score. Being old and having a low level of education were found to be important risk factors for inadequate medication understanding. This and other data suggest that sponsors should encourage initiatives aimed at improving investigational medication understanding in adults enrolled in clinical trials.

TRANSRECTAL ULTRASONOGRAPHY OF EQUINE LUMBOSACRAL NERVES: PILOT STUDY IN 28 HEALTHY WARMBLOOD HORSES.

A noninvasive method for visualizing lumbosacral nerves would be helpful for horses with suspected lumbosacral plexopathy or injury. The aim of this prospective descriptive pilot study was to characterize the ultrasonographic appearance of the lumbosacral nerves in a sample of healthy horses, and expand on the technique for image acquisition. Horses were recruited for inclusion if they were determined to be healthy and sound based on clinical and lameness evaluation. Transrectal ultrasound images of the lumbosacral nerves (L6, S1, and S2) were obtained for both sides. Landmarks for localization, and techniques for nerve identification and measurement were described. Effects of sex, age, side, and nerve on measured thickness were statistically tested. Twenty-eight warmblood horses were sampled (15 males and 13 females). Ages ranged from 5 to 15 years. Ventral nerve roots from L6 to S2 appeared as tubular structures with a characteristic hyperechoic linear echo pattern. There was no significant difference in nerve vertical diameter between left and right sides. A three-way interaction was found among sex, age and lumbosacral nerve. The L6 nerve in males was significantly larger than S1 only in the youngest group. The S2 nerve was significantly smaller than L6 or S1 regardless of age group or sex. In conclusion, transrectal ultrasound was a feasible method for visualizing and measuring equine lumbosacral nerves. Wide ranges of sizes for each nerve were found between horses, however nerves were bilaterally symmetrical within horses. Side comparison is therefore recommended when nerve pathology is suspected.

The perceived exertion to regulate a training program in young women.

The aim of this study was to compare the heart rate (HR) and the perceived exertion (PE) regulation of a training program in women and their effects on the cardiorespiratory responses. Twenty-seven women (mean age 22.4 ± 2.7 years) were randomly assigned to a control group (CG, n = 9), a heart rate group (HRG, n = 9), or a perceptive group (PG, n = 9). All subjects performed a maximal graded test (MGT) on a cycle ergometer before and after 6 weeks. The HR, V(O2)peak, maximal tolerated power (MTP), and PE were recorded during both MGTs. A 6-week interval training program was performed by both the HRG and PG. HR targets were used for the HRG and PE for the PG to readjust the power output. The results show that the V(O2)peak and the MTP increased significantly (p < 0.05) for both training groups, whereas the CG obtained no changes. As a consequence, PE could be a valuable tool to readjust the training load during an interval training program.

Determination of the ventilatory threshold with affective valence and perceived exertion in trained cyclists: a preliminary study.

The aim of the present study was to determine if trained cyclists have perceptual markers that can be used to identify the ventilatory threshold during a maximal exercise test. Ten trained cyclists (age 25.20 +/- 4.94 years; VO2max 63.6 +/- 6.3 mL x min(-1) x kg(-1)) performed a maximal graded test on a cycling ergometer. Perceived exertion and affective valence were measured each min of the maximal graded test. The results indicate that ventilatory threshold, perceived exertion, and affective valence are significantly different compared to the values assessed 1 minute after ventilatory threshold. Moreover, there were a significant relationships between power output and perceived exertion (p < 0.01; r = 0.97) and affective valence (p < 0.01; r = 0.94) measured during the maximal graded test. These results confirm that at ventilatory threshold a lot of significant changes of perceptual parameters appear and may be good indicators for athletes to determine their ventilatory threshold during a training session. This method could be interesting for cyclists to control the exercise intensity during individual time trial.

Effects of steady-state exercise on perceived pain: comparison of sedentary students and cyclists.

In this study, the effect of fitness level on perceived pain before and after a steady state exercise was investigated. Ten trained cyclists (M age=25.2 yr., SD=4.9) and 10 sedentary men (Mage=24.5 yr., SD=2.2) performed a maximal graded test on a cycle ergometer. At least 48 hr. later the participants of both groups performed a 30-min. steady-state cycling test at 75% of VO2 max. Before the steady-state exercise and 5- and 30-min. postexercise, a pressure pain stimulation test was applied on the finger of each participant. Perceived pain was measured with Borg's CR10 scale at the end of each pain stimulation. The results indicated no significant changes in perceived pain between the pre-exercise and 5- and 30-min. postexercise values (effect sizes=.07 and .19, respectively). Moreover, no significant difference in perceived pain was found between the groups for pre-exercise (ES=.02) and 5- and 30-min. postexercise (ES=.16 and .21, respectively) values. These results do not confirm the analgesic effects usually observed after steady state exercise. Therefore, it is not possible to compare the analgesic effect of this exercise mode between participants characterized by different fitness levels.