1.
Bioorg Med Chem Lett
; 21(1): 191-4, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21134747
RESUMO
Herein we describe the synthesis and structure activity relationship of a new class of FXR agonists identified from a high-throughput screening campaign. Further optimization of the original hits led to molecules that were highly active in an LDL-receptor KO model for dyslipidemia. The most promising candidate is discussed in more detail.