WHO and its transformation - A journey from 1978 to 2024.

The Alma-Ata Declaration of 1978 was a historic hallmark in the history of public health of the 20th century. It stressed on comprehensive primary health care and led to the slogan of "Health for All by 2000 A.D." The Conference documents made it clear that primary health care was essential health care based on practical, scientifically sound, and socially acceptable methods and technology made universally accessible to individuals and families in the community through their full participation and at a cost that the community and country could afford to maintain at every stage of their development in the spirit of self-reliance and self-determination. It was proclaimed to form an integral part of a country's health system. In addition, as a consequence, the overall social and economic development of the community depended on its survival. It was regarded as the first level of contact of individuals, the family, and community with the national health system bringing health care as close as possible to where people live and work. Instead of disease-centred vertical programs, it emphasised to adopt the horizontal community-based programs. Though the worldwide stir caused by the historic Alma-Ata Conference (1978), giant MNCs of the world remained hibernated for some time but never gave up to turn "health" into "health care" as commodity. Intriguingly enough, health was "forgotten" when the Covenant of the League of Nations was drafted after the First World War. Only at the last moment, world health was included, leading to the Health Section of the League of Nations. Recently, Intergovernmental Negotiating Body has drafted a new Pandemic Treaty which might become disastrous for general well-being and rightful living for citizens in future. All these observations are very much relevant if family medicine and primary care are given due importance at the present moment.

Co-pyrolysis of plastic waste and eucalyptus waste wood for fuel pellets production: A study of fuel, mechanical, and combustion characteristics under varying binder proportion.

The study explores the effect of varying molasses proportions as a binder on the characteristics of densified char obtained through the slow co-pyrolysis of plastic waste and Eucalyptus wood waste (Waste low-density polyethylene - Eucalyptus wood (WLDPE-EW) and Waste Polystyrene - Eucalyptus wood (WPS-EW)). Pyrolysis was conducted at 500 °C with a residence time of 120 min, employing plastic to wood waste ratios of 1:2 and 1:3 (w/w). The focus was on how varying the proportion of molasses (10-30 %), influences the physical and combustion properties of the resulting biofuel pellets. Our findings reveal that the calorific value of the pellets decreased from 28.94 to 27.44 MJ/Kg as the molasses content increased. However, this decrease in calorific value was compensated by an increase in pellet mass density, which led to a higher energy density overall. This phenomenon was attributed to the formation of solid bridges between particles, facilitated by molasses, effectively decreasing particle spacing. The structural integrity of the pellets, as measured by the impact resistance index, improved significantly (43-47 %) with the addition of molasses. However, a significant change in the combustion characteristics depicted by lower ignition and burnout temperatures were observed due to decrease in fixed carbon value and increase in volatile matter content, as the proportion of molasses increased. Despite these changes, the pellets demonstrated a stable combustion profile, suggesting that molasses are an effective binder for producing biofuel pellets through the densification of char derived from the co-pyrolysis of plastic and Eucalyptus wood waste. The optimized molasses concentration analyzed through multifactor regression analysis was 16.96 % with 28 % WLDPE proportion to produce WLDPE-EW char pellets. This study highlights the potential of using molasses as a sustainable binder to enhance the mechanical and combustion properties of biofuel pellets, offering a viable pathway for the valorization of waste materials.

Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria.

Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequency of administration and thereby potentially patient compliance. Here, we report on an Fc-engineered variant with three amino acid substitutions Q311R/M428E/N434W (REW), that enhances plasma half-life and mucosal distribution, as well as allows for needle-free delivery across respiratory epithelial barriers in human FcRn transgenic mice. In addition, the Fc-engineered variant improves on-target complement-mediated killing of cancer cells as well as both gram-positive and gram-negative bacteria. Hence, this versatile Fc technology should be broadly applicable in antibody design aiming for long-acting prophylactic or therapeutic interventions.

Is income inequality linked to infectious disease prevalence? A hypothesis-generating study using tuberculosis.

We study the association between infectious disease incidence and income inequality. We hypothesize that random social mixing in an income-unequal society brings into contact a) susceptible and infected poor and b) the infected-poor and the susceptible-rich, raising infectious disease incidence. We analyzed publicly available, country-level panel data for a large cross-section of countries between 1995 and 2013 to examine whether countries with elevated levels of income inequality have higher rates of pulmonary Tuberculosis (TB) incidence per capita. A "negative control" using anemia and diabetes (both non-communicable diseases and hence impervious to the hypothesized mechanism) is also applied. We find that high levels of income inequality are positively associated with tuberculosis incidence. All else equal, countries with income-Gini coefficients 10% apart show a statistically significant 4% difference in tuberculosis incidence. Income inequality had a null effect on the negative controls. Our cross-country regression results suggest that income inequality may create conditions where TB spreads more easily, and policy action to reduce income inequities could directly contribute to a reduced TB burden.