Malignancy pattern analysis of breast ultrasound images using clinical features and a graph convolutional network.

Objective: Early diagnosis of breast cancer can lead to effective treatment, possibly increase long-term survival rates, and improve quality of life. The objective of this study is to present an automated analysis and classification system for breast cancer using clinical markers such as tumor shape, orientation, margin, and surrounding tissue. The novelty and uniqueness of the study lie in the approach of considering medical features based on the diagnosis of radiologists. Methods: Using clinical markers, a graph is generated where each feature is represented by a node, and the connection between them is represented by an edge which is derived through Pearson's correlation method. A graph convolutional network (GCN) model is proposed to classify breast tumors into benign and malignant, using the graph data. Several statistical tests are performed to assess the importance of the proposed features. The performance of the proposed GCN model is improved by experimenting with different layer configurations and hyper-parameter settings. Results: Results show that the proposed model has a 98.73% test accuracy. The performance of the model is compared with a graph attention network, a one-dimensional convolutional neural network, and five transfer learning models, ten machine learning models, and three ensemble learning models. The performance of the model was further assessed with three supplementary breast cancer ultrasound image datasets, where the accuracies are 91.03%, 94.37%, and 89.62% for Dataset A, Dataset B, and Dataset C (combining Dataset A and Dataset B) respectively. Overfitting issues are assessed through k-fold cross-validation. Conclusion: Several variants are utilized to present a more rigorous and fair evaluation of our work, especially the importance of extracting clinically relevant features. Moreover, a GCN model using graph data can be a promising solution for an automated feature-based breast image classification system.

Improving the Automated Diagnosis of Breast Cancer with Mesh Reconstruction of Ultrasound Images Incorporating 3D Mesh Features and a Graph Attention Network.

This study proposes a novel approach for breast tumor classification from ultrasound images into benign and malignant by converting the region of interest (ROI) of a 2D ultrasound image into a 3D representation using the point-e system, allowing for in-depth analysis of underlying characteristics. Instead of relying solely on 2D imaging features, this method extracts 3D mesh features that describe tumor patterns more precisely. Ten informative and medically relevant mesh features are extracted and assessed with two feature selection techniques. Additionally, a feature pattern analysis has been conducted to determine the feature's significance. A feature table with dimensions of 445 × 12 is generated and a graph is constructed, considering the rows as nodes and the relationships among the nodes as edges. The Spearman correlation coefficient method is employed to identify edges between the strongly connected nodes (with a correlation score greater than or equal to 0.7), resulting in a graph containing 56,054 edges and 445 nodes. A graph attention network (GAT) is proposed for the classification task and the model is optimized with an ablation study, resulting in the highest accuracy of 99.34%. The performance of the proposed model is compared with ten machine learning (ML) models and one-dimensional convolutional neural network where the test accuracy of these models ranges from 73 to 91%. Our novel 3D mesh-based approach, coupled with the GAT, yields promising performance for breast tumor classification, outperforming traditional models, and has the potential to reduce time and effort of radiologists providing a reliable diagnostic system.

Graph neural network-based breast cancer diagnosis using ultrasound images with optimized graph construction integrating the medically significant features.

PURPOSE: An automated computerized approach can aid radiologists in the early diagnosis of breast cancer. In this study, a novel method is proposed for classifying breast tumors into benign and malignant, based on the ultrasound images through a Graph Neural Network (GNN) model utilizing clinically significant features. METHOD: Ten informative features are extracted from the region of interest (ROI), based on the radiologists' diagnosis markers. The significance of the features is evaluated using density plot and T test statistical analysis method. A feature table is generated where each row represents individual image, considered as node, and the edges between the nodes are denoted by calculating the Spearman correlation coefficient. A graph dataset is generated and fed into the GNN model. The model is configured through ablation study and Bayesian optimization. The optimized model is then evaluated with different correlation thresholds for getting the highest performance with a shallow graph. The performance consistency is validated with k-fold cross validation. The impact of utilizing ROIs and handcrafted features for breast tumor classification is evaluated by comparing the model's performance with Histogram of Oriented Gradients (HOG) descriptor features from the entire ultrasound image. Lastly, a clustering-based analysis is performed to generate a new filtered graph, considering weak and strong relationships of the nodes, based on the similarities. RESULTS: The results indicate that with a threshold value of 0.95, the GNN model achieves the highest test accuracy of 99.48%, precision and recall of 100%, and F1 score of 99.28%, reducing the number of edges by 85.5%. The GNN model's performance is 86.91%, considering no threshold value for the graph generated from HOG descriptor features. Different threshold values for the Spearman's correlation score are experimented with and the performance is compared. No significant differences are observed between the previous graph and the filtered graph. CONCLUSION: The proposed approach might aid the radiologists in effective diagnosing and learning tumor pattern of breast cancer.