Assuntos
Antitrombinas/efeitos adversos , Benzimidazóis/efeitos adversos , Hemorragia/terapia , beta-Alanina/análogos & derivados , Animais , Coagulantes/uso terapêutico , Dabigatrana , Fator VIIa/uso terapêutico , Hemorragia/induzido quimicamente , Humanos , Protrombina/uso terapêutico , Proteínas Recombinantes/uso terapêutico , Diálise Renal , beta-Alanina/efeitos adversosRESUMO
More than 90% of cases of pneumocystis pneumonia (PCP) in adults occur in patients with chronic HIV infection with CD4 counts lower than 200 cells/ml. Even though primary HIV infection can cause transient profound CD4 lymphocytopenia, PCP is rarely reported during primary HIV infection. We report a case of a 26-year-old man who was diagnosed with PCP in the setting of primary HIV infection. He was successfully treated with a 21-day course of oral co-trimoxazole.
Assuntos
Infecções Oportunistas Relacionadas com a AIDS/microbiologia , Pneumonia por Pneumocystis/virologia , Adulto , Anti-Infecciosos/uso terapêutico , Infecções por HIV/microbiologia , Humanos , Masculino , Pneumonia por Pneumocystis/tratamento farmacológico , Combinação Trimetoprima e Sulfametoxazol/uso terapêuticoRESUMO
Denosumab, a human monoclonal antibody to the receptor activator of nuclear factor-κB ligand, is a novel therapy to osteoporotic fracture and skeletal-related events in patients with bone metastases. Hypocalcemia is its known adverse effect, although it is generally mild and transient and usually occurs in patients with severe chronic kidney disease or end-stage renal disease. We reported a case 61-year-old woman who received a single dose of denosumab and developed severe symptomatic hypocalcemia associated with prolong QTc interval requiring hospitalization for intravenous calcium.
Assuntos
Anticorpos Monoclonais Humanizados/efeitos adversos , Anticorpos Monoclonais/efeitos adversos , Neoplasias Ósseas/tratamento farmacológico , Neoplasias da Mama/patologia , Hipocalcemia/induzido quimicamente , Neoplasias Ósseas/complicações , Neoplasias Ósseas/secundário , Denosumab , Feminino , Humanos , Hipocalcemia/terapia , Pessoa de Meia-Idade , Insuficiência Renal/complicaçõesRESUMO
Acute monoarthritis is one of the most common rheumatologic presentations. However, it is clinically difficult to distinguish between an inflamed joint due to crystal-induced arthritis and an inflamed joint due to septic arthritis. Arthrocentesis and synovial fluid analysis are used to differentiate between these 2 conditions. The presence of crystals and positive synovial fluid culture confirm the diagnosis of crystal-induced arthritis and septic arthritis, respectively. Although uncommon, these 2 arthritides can coexist, and presence of crystal does not exclude bacterial arthritis. We reported a case of 85-year-old woman whose synovial fluid contained crystals and was initially diagnosed with crystal-induced arthritis. However, her joint fluid culture subsequently grew Staphylococcus aureus, and she was treated with arthroscopic debridement and antibiotics.