RESUMO
We studied the particularities of osteo- and angiogenesis in albino rats after implantation of polycaprolactone scaffolds mineralized with vaterite with adsorbed tannic acid in the femoral bone defect. It was found that the processes of angio- and osteogenesis in the bone tissue after scaffolds implantation depend on their biocompatibility. Implantation of non-biocompatible scaffolds was followed by activation of angio- and osteogenesis aimed at separation of these scaffold from surrounding tissues. Implantation of polycaprolactone/vaterite scaffolds containing tannic acid stimulated angio- and osteogenesis leading to vascularization and bone tissue formation in the matrix. This demonstrate prospects of clinical approbation of these scaffolds for stimulation of bone regeneration in traumatological and orthopedic patients.
Assuntos
Regeneração Óssea/efeitos dos fármacos , Carbonato de Cálcio/química , Poliésteres/química , Taninos/química , Alicerces Teciduais/química , Animais , Osso e Ossos/citologia , Masculino , Ratos , Taninos/farmacologiaRESUMO
The paper proposes to measure the serum content of medium-weight molecules as a simple and available means of rapidly and adequately assessing the total activity of an inflammatory process (including the minimal one) in patients with rheumatoid arthritis. The method may be performed at any powered clinical diagnostic laboratories; it does not require expensive reagents and equipment, and special staff training.