RESUMO
Treatment of intracranial arteriovenous malformations is complex and multidisciplinary. This article presents the treatment model utilized in Christchurch, New Zealand which provides cerebrovascular surgery and interventional neuroradiology to the entire south island (approximate population of 1.1 million). A total of 40 patients treated over a 10 year period (2004-2014) are analysed here. Nine patients were managed surgically and complete resection was achieved in 100% of cases. Permanent mortality was 0% and permanent morbidity was 22% however median mRS improved from 3.0 preoperatively to 1.0 at follow up. Embolisation was utilized in 31 patients (mean age 40), of which 45% presented with haemorrhage, 39% with seizures, 10% with a headache only, and 6% with a deficit. None were found incidentally. The Spetzler-Martin grade 1 cases accounted for 10% of the cohort, 23% were grade II, 42% grade III, 23% grade IV and 3% grade V. A single aneurysm was present in 42% of cases, and multiple in 13%. The nidus was obliterated in 9.6% of cases with a morbidity rate of 6.5% and mortality rate of 3%. Modified Rankin scale improved marginally from 0.9 at diagnosis to 0.88 at final follow up (mean 22 months). There were no cases of recanalization. The total nidus obliteration rate using our algorithm of surgery alone for small accessible lesions, then staged embolization for larger lesions with adjuvant radiosurgery reserved for cases with residual nidus, was 50%.
Assuntos
Malformações Arteriovenosas Intracranianas/cirurgia , Malformações Arteriovenosas Intracranianas/terapia , Adolescente , Adulto , Criança , Estudos de Coortes , Terapia Combinada , Embolização Terapêutica , Feminino , Cefaleia/cirurgia , Hemisferectomia , Humanos , Masculino , Microcirurgia , Pessoa de Meia-Idade , Nova Zelândia , Psicocirurgia , Radiocirurgia , Estudos Retrospectivos , Convulsões/cirurgia , Técnicas Estereotáxicas , Resultado do TratamentoRESUMO
BACKGROUND AND PURPOSE: Delayed cerebral ischemia (DCI) is an important cause of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). Trials of magnesium treatment starting <4 days after symptom onset found no effect on poor outcome or DCI in SAH. Earlier installment of treatment might be more effective, but individual trials had not enough power for such a subanalysis. We performed an individual patient data meta-analysis to study whether magnesium is effective when given within different time frames within 24 hours after the SAH. METHODS: Patients were divided into categories according to the delay between symptom onset and start of the study medication: <6, 6 to 12, 12 to 24, and >24 hours. We calculated adjusted risk ratios with corresponding 95% confidence intervals for magnesium versus placebo treatment for poor outcome and DCI. RESULTS: We included 5 trials totaling 1981 patients; 83 patients started treatment<6 hours. For poor outcome, the adjusted risk ratios of magnesium treatment for start <6 hours were 1.44 (95% confidence interval, 0.83-2.51); for 6 to 12 hours 1.03 (0.65-1.63), for 12 to 24 hours 0.84 (0.65-1.09), and for >24 hours 1.06 (0.87-1.31), and for DCI, <6 hours 1.76 (0.68-4.58), for 6 to 12 hours 2.09 (0.99-4.39), for 12 to 24 hours 0.80 (0.56-1.16), and for >24 hours 1.08 (0.88-1.32). CONCLUSIONS: This meta-analysis suggests no beneficial effect of magnesium treatment on poor outcome or DCI when started early after SAH onset. Although the number of patients was small and a beneficial effect cannot be definitively excluded, we found no justification for a new trial with early magnesium treatment after SAH.
Assuntos
Isquemia Encefálica/prevenção & controle , Bloqueadores dos Canais de Cálcio/administração & dosagem , Aneurisma Intracraniano , Sulfato de Magnésio/administração & dosagem , Hemorragia Subaracnóidea/tratamento farmacológico , Tempo para o Tratamento/estatística & dados numéricos , Vasoespasmo Intracraniano/prevenção & controle , Aneurisma Roto/complicações , Bloqueadores dos Canais de Cálcio/uso terapêutico , Intervenção Médica Precoce , Humanos , Sulfato de Magnésio/uso terapêutico , Hemorragia Subaracnóidea/etiologia , Resultado do TratamentoAssuntos
Antiarrítmicos/sangue , Sulfato de Magnésio/sangue , Animais , Antiarrítmicos/administração & dosagem , Antiarrítmicos/uso terapêutico , Humanos , Infusões Intravenosas , Sulfato de Magnésio/administração & dosagem , Sulfato de Magnésio/uso terapêutico , Ratos , Hemorragia Subaracnóidea/tratamento farmacológicoRESUMO
We report a case of a third ventricular cavernous haemangioma (cavernoma). Cavernomas rarely occur within the ventricular system. Only 47 well-documented cases have been reported in the literature, 21 of which were located in the third ventricle. Cavernomas should be considered in the differential diagnosis of third ventricular lesions. Ventriculoscopy is very useful in establishing the diagnosis.
Assuntos
Neoplasias do Ventrículo Cerebral/diagnóstico , Hemangioma Cavernoso do Sistema Nervoso Central/diagnóstico , Terceiro Ventrículo/patologia , Neoplasias do Ventrículo Cerebral/fisiopatologia , Neoplasias do Ventrículo Cerebral/cirurgia , Endoscopia , Feminino , Perda Auditiva/etiologia , Hemangioma Cavernoso do Sistema Nervoso Central/fisiopatologia , Hemangioma Cavernoso do Sistema Nervoso Central/cirurgia , Humanos , Hidrocefalia/etiologia , Hidrocefalia/fisiopatologia , Hidrocefalia/cirurgia , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/fisiopatologia , Terceiro Ventrículo/fisiopatologia , Terceiro Ventrículo/cirurgia , Zumbido/etiologia , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Inconsciência/etiologia , Inconsciência/fisiopatologia , Derivação VentriculoperitonealRESUMO
BACKGROUND: Decompressive surgery and steroid injection are widely used forms of treatment for carpal tunnel syndrome (CTS) but there is no consensus on their effectiveness in comparison to each other. The authors evaluated the efficacy of surgery vs steroid injection in relieving symptoms in patients with CTS. METHODS: The authors conducted a randomized, single blind, controlled trial. Fifty patients with electrophysiologically confirmed idiopathic CTS were randomized and assigned to open carpal tunnel release (25 patients) or to a single injection of steroid (25 patients). Patients were followed up at 6 and 20 weeks. The primary outcome was symptom relief in terms of the Global Symptom Score (GSS), which rates symptoms on a scale of 0 (no symptoms) to 50 (most severe). Nerve conduction studies and grip strength measurements were used as secondary outcome assessments. RESULTS: At 20 weeks after randomization, patients who underwent surgery had greater symptomatic improvement than those who were injected. The mean improvement in GSS after 20 weeks was 24.2 (SD 11.0) in the surgery group vs 8.7 (SD 13.0) in the injection group (p < 0.001); surgical decompression also resulted in greater improvement in median nerve distal motor latencies and sensory nerve conduction velocity. Mean grip strength in the surgical group was reduced by 1.7 kg (SD 5.1) compared with a gain of 2.4 kg (SD 5.5) in the injection group. CONCLUSION: Compared with steroid injection, open carpal tunnel release resulted in better symptomatic and neurophysiologic outcome but not grip strength in patients with idiopathic carpal tunnel syndrome over a 20-week period.
Assuntos
Articulações do Carpo/efeitos dos fármacos , Articulações do Carpo/cirurgia , Síndrome do Túnel Carpal/tratamento farmacológico , Síndrome do Túnel Carpal/cirurgia , Descompressão Cirúrgica/estatística & dados numéricos , Esteroides/administração & dosagem , Esteroides/efeitos adversos , Adulto , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/efeitos adversos , Articulações do Carpo/fisiopatologia , Síndrome do Túnel Carpal/fisiopatologia , Descompressão Cirúrgica/normas , Relação Dose-Resposta a Droga , Vias de Administração de Medicamentos , Esquema de Medicação , Feminino , Humanos , Ligamentos/patologia , Ligamentos/fisiopatologia , Ligamentos/cirurgia , Masculino , Nervo Mediano/efeitos dos fármacos , Nervo Mediano/patologia , Nervo Mediano/fisiopatologia , Metilprednisolona/administração & dosagem , Metilprednisolona/efeitos adversos , Pessoa de Meia-Idade , Debilidade Muscular/etiologia , Condução Nervosa/efeitos dos fármacos , Condução Nervosa/fisiologia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/fisiopatologia , Estudos Prospectivos , Prevenção Secundária , Resultado do TratamentoRESUMO
OBJECT: The treatment of 21 paraclinoid/ophthalmic segment internal carotid artery aneurysms (PCOSAs) over a seven year period in a regional neurosurgical center was reviewed to assess the degree of obliteration and recurrence rate of these aneurysms after treatment by surgical and endovascular methods. METHOD AND RESULT: An assessment of the clinical notes, operation records and cerebral angiograms was made to evaluate the rate of residual and recurrent aneurysms after treatment and at follow-up. In the coiling group, the aneurysm recurrence rate was eight out of fifteen aneurysms (53%). Four recurrences were from previously totally occluded aneurysms. Out of the six surgical cases, five had follow-up angiography performed. All had stable occlusions of their aneurysms including one with subtotal occlusion. Two clipping procedures after previous coiling achieved total occlusion of aneurysm on follow-up angiography. CONCLUSION: Based on our case series we conclude that PCOSAs frequently recur after primary treatment. GDC coiling was associated with a higher rate of recurrent aneurysms when compared with surgical treatment. A review of the literature on the surgical and endovascular treatment of PCOSAs support this observation.
Assuntos
Angioplastia , Artéria Carótida Interna , Embolização Terapêutica , Aneurisma Intracraniano/terapia , Procedimentos Neurocirúrgicos , Artéria Oftálmica , Adulto , Idoso , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Retratamento , Estudos Retrospectivos , Sela Túrcica , Resultado do TratamentoRESUMO
From a series of 112 cases (64 men and 48 women, aged 37 - 91 years) of chronic subdural haematoma (CSDH) in a 2-year period from January 1998 to December 1999, we have prospectively studied a group of 30 patients, who were managed non-operatively: 26 patients were treated with dexamethasone (Group 1) and four patients expectantly (Group 4). Nineteen patients (73%) from Group 1 were confused or had focal neurological deficits on admission. The mean maximum thickness of the CSDH was 12 mm. Only one of these cases (4%) required surgical drainage 6 weeks after steroid therapy. One patient died of an unrelated stroke (mortality = 4%). Two patients (8%) were left severely disabled. No significant complication from steroid therapy was documented. Out of the 85 surgically treated patients, 69 patients underwent surgical drainage in addition to steroid therapy (Group 2). Thirteen patients were treated with burr-hole drainage only (Group 3). The mean maximum thickness of the CSDH for these two groups were both 16 mm. Comparing with group 1, the redrainage rate of Group 2 [4% (3/69, p = 1)] and that of Group 3 [15% (2/13, p = 0.253)] were not significantly different. 50% of patients in Group 4 (2/4, p = 0.039) required delayed surgical drainage. The mortality rates of Groups 2, 3 and 4 were 3% (2/69, p = 1), 15% (2/13, p = 0.253) and 50% (2/4, p = 0.039), respectively. Our results suggest that steroid treatment in a selected group of patients is a good option, particularly in patients with co-morbidity.
Assuntos
Anti-Inflamatórios/uso terapêutico , Dexametasona/uso terapêutico , Hematoma Subdural Crônico/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Terapia Combinada , Drenagem , Feminino , Escala de Coma de Glasgow , Hematoma Subdural Crônico/diagnóstico por imagem , Hematoma Subdural Crônico/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
Previous studies have demonstrated that a brief period of ischemia protect against subsequent severe ischemic insults to the brain, i.e. preconditioning. We evaluated the effects of ischemic preconditioning, produced by 2 min proximal temporary artery occlusion, on brain tissue gases and acidity during clipping of cerebral aneurysm. Twelve patients with aneurysmal subarachnoid hemorrhage were recruited. All patients received standard anesthetics. After craniotomy, a calibrated multiparameter catheter was inserted to measure oxygen (PtO2) tension, carbon dioxide (PtCO2) tension and pH (pHt) in tissue at risk of ischemia during temporary artery occlusion. In patients assigned to the preconditioning group, proximal artery was occluded initially for 2 min and was allowed to reperfuse for 30 min. All patients underwent cerebral artery occlusion for clipping of aneurysm. The rate of change in PtO2, PtCO2 and pHt after artery occlusion were compared between groups using unpaired t test. Baseline brain tissue gases and pHt were similar between groups. Following artery occlusion, the decline in PtO2 and pHt were significantly slower in the preconditioning group compared with the routine care group. These results suggested that ischemic preconditioning attenuates tissue hypoxia during subsequent artery occlusion. Brief occlusion of the proximal artery may be a simple maneuver for brain protection during complex cerebrovascular surgery.
Assuntos
Química Encefálica , Dióxido de Carbono/metabolismo , Precondicionamento Isquêmico/métodos , Oxigênio/metabolismo , Hemorragia Subaracnóidea/metabolismo , Hemorragia Subaracnóidea/terapia , Adulto , Idoso , Artérias Cerebrais , Transtornos Cerebrovasculares/complicações , Transtornos Cerebrovasculares/metabolismo , Feminino , Gases/metabolismo , Humanos , Concentração de Íons de Hidrogênio , Masculino , Pessoa de Meia-Idade , Hemorragia Subaracnóidea/complicações , Hemorragia Subaracnóidea/cirurgia , Resultado do TratamentoRESUMO
We evaluated the effects of magnesium sulfate on brain tissue oxygen (PtO2) tension, carbon dioxide (PtCO2) tension and pH (pHt) in patients undergoing temporary artery occlusion for clipping of cerebral aneurysm. We studied 18 patients with aneurysmal subarachnoid hemorrhage. All patients received standard anesthetics using target controlled infusion of propofol (3 microg/ml) and remifentanil (10 ng/ml). After craniotomy, a calibrated multiparameter sensor (Neurotrend, Diametrics Medical, Minneapolis, MN) was inserted to measure PtO2, PtCO2 and pHt in tissue at risk of ischemia during temporary artery occlusion. Patients were then randomly allocated to receive either intravenous saline or magnesium 20 mmol over 10 min followed by an infusion 4 mmol/h. Plasma magnesium concentration, brain tissue gases and pHt were determined at baseline, 30 min after study drug infusion and 4 min after temporary clipping. Data were analyzed by factorial ANOVA with repeated measures. Intergroup difference was compared with unpaired t test. P value < 0.05 was considered significant. Patient characteristics, baseline brain tissue gases and pHt did not differ between groups. Magnesium infusion increased PtO2 by 34%. Following temporary artery occlusion, PtO2 and pHt decreased and PtCO2 increased in both groups. However, tissue hypoxia was less severe and the rate of PtO2 decline was slower in the magnesium group. Our data suggested that magnesium enhances tissue oxygenation and attenuates hypoxia during temporary artery occlusion.
Assuntos
Isquemia Encefálica/prevenção & controle , Encéfalo/metabolismo , Precondicionamento Isquêmico/métodos , Sulfato de Magnésio/administração & dosagem , Oxigênio/metabolismo , Hemorragia Subaracnóidea/terapia , Encéfalo/efeitos dos fármacos , Isquemia Encefálica/etiologia , Isquemia Encefálica/metabolismo , Feminino , Humanos , Infarto da Artéria Cerebral Média/complicações , Infarto da Artéria Cerebral Média/metabolismo , Precondicionamento Isquêmico/efeitos adversos , Masculino , Pessoa de Meia-Idade , Fármacos Neuroprotetores/administração & dosagem , Hemorragia Subaracnóidea/complicações , Hemorragia Subaracnóidea/metabolismo , Resultado do Tratamento , Vasodilatadores/administração & dosagemRESUMO
OBJECTIVES: Magnesium sulfate (MgSO4) may be useful in preventing neurological injury after subarachnoid haemorrhage (SAH). In this randomized, double-blind study we evaluated the safety and efficacy of MgSO4 infusion to improve clinical outcome after aneurysmal SAH. METHODS: With ethics committee approval and informed consents, 45 patients with SAH were randomly allocated to receive either MgSO4 80 mmol/day or saline infusion for 14 days. All patients also received intravenous nimodipine. Episodes of vasospasm were treated with hypertensive, hypervolemic therapy. Neurological status was assessed 3 months after haemorrhage using Barthel index and Glasgow outcome scale (GOS). Incidences of cardiac and pulmonary complications were also recorded. Data were compared between groups using Mann-Whitney or Fisher exact tests as appropriate. P < 0.05 was considered significant. RESULTS: Patient characteristics, severity of SAH and surgical treatment did not differ between groups. Although the number of episodes was not reduced, MgSO4 shortened the duration of vasospasm. Patients receiving MgSO4 tended to have fewer neurological deficits, better functional recovery and an improved score in GOS. However, none of these outcome variables reached statistical significance. The incidence of cardiac and pulmonary complications in the MgSO4 group (43%) was also similar to that in the saline group (59%), P = 0.14. CONCLUSIONS: MgSO4 infusion after aneurysmal SAH is well tolerated and may be useful in producing better outcome. A larger study is required to confirm the neuroprotective effect of MgSO4.
Assuntos
Sulfato de Magnésio/administração & dosagem , Medição de Risco/métodos , Hemorragia Subaracnóidea/tratamento farmacológico , Hemorragia Subaracnóidea/mortalidade , Vasoespasmo Intracraniano/mortalidade , Vasoespasmo Intracraniano/prevenção & controle , Comorbidade , Método Duplo-Cego , Feminino , Hong Kong/epidemiologia , Humanos , Incidência , Infusões Intravenosas , Masculino , Pessoa de Meia-Idade , Avaliação de Resultados em Cuidados de Saúde , Projetos Piloto , Prognóstico , Fatores de Risco , Resultado do Tratamento , Vasodilatadores/administração & dosagemRESUMO
INTRODUCTION: Digital subtraction angiography is recognized as the standard investigation for isolated third nerve palsy thought to be caused by an expanding aneurysm. We reviewed our experience in using computed tomographic angiography (CTA) as the first line investigation for patients presenting with isolated third nerve palsy without subarachnoid hemorrhage. METHOD: We retrieved the medical records of 34 patients who had presented with isolated third nerve palsy without associated subarachnoid hemorrhage to our institution between January 1998 and July 2001. The clinical history, course and outcome as well as the radiological data was reviewed. RESULTS: A total of nine structural lesions (26%) were noted as the etiology of the third nerve palsy. All of the five posterior communicating artery aneurysms were picked up by the CTA. Neither the presence nor the absence of painful complete third nerve palsy was of diagnostic value for intracranial aneurysm. CONCLUSION: A good quality CTA is sufficient to detect a compressive aneurysm and may detect other structural lesions. This allows neurosurgeons to plan the management of patients with isolated third nerve palsy. Patients in whom CTA results are inconclusive should be further investigated with catheter angiography.
Assuntos
Angiografia Cerebral , Aneurisma Intracraniano/diagnóstico por imagem , Doenças do Nervo Oculomotor/diagnóstico por imagem , Tomografia Computadorizada Espiral , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Angiografia Digital , Criança , Feminino , Humanos , Aneurisma Intracraniano/complicações , Aneurisma Intracraniano/cirurgia , Masculino , Pessoa de Meia-Idade , Doenças do Nervo Oculomotor/etiologia , Sensibilidade e Especificidade , Resultado do TratamentoRESUMO
We report a case of malignant intraventricular meningioma with CSF drop metastases and an implantation metastatic subgaleal nodule in a 53-year-old woman. Malignant intraventricular meningiomas are rare with only seven cases being reported in the literature. These tumours can be very aggressive and one should consider immediate postoperative radiotherapy.
Assuntos
Neoplasias do Ventrículo Cerebral/patologia , Neoplasias Meníngeas/patologia , Meningioma/patologia , Neoplasias da Coluna Vertebral/secundário , Craniotomia/métodos , Feminino , Humanos , Imageamento por Ressonância Magnética , Neoplasias Meníngeas/cirurgia , Meningioma/cirurgia , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Neoplasias da Coluna Vertebral/cirurgia , Tomografia Computadorizada por Raios X/métodosRESUMO
A young man presented with quadriparesis and spinal shock because of a spontaneous cervical spinal epidural haematoma was reported. Immediate MRI diagnosis followed by emergency decompression with six hours of presentation resulted in complete recovery.
Assuntos
Hematoma Epidural Espinal/complicações , Hematoma Epidural Espinal/fisiopatologia , Quadriplegia/etiologia , Quadriplegia/fisiopatologia , Compressão da Medula Espinal/etiologia , Compressão da Medula Espinal/fisiopatologia , Medula Espinal/fisiopatologia , Adulto , Vértebras Cervicais/diagnóstico por imagem , Vértebras Cervicais/patologia , Descompressão Cirúrgica , Espaço Epidural/diagnóstico por imagem , Espaço Epidural/patologia , Hematoma Epidural Espinal/patologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pescoço , Cervicalgia/etiologia , Cervicalgia/patologia , Quadriplegia/patologia , Radiografia , Medula Espinal/patologia , Compressão da Medula Espinal/patologia , Resultado do Tratamento , Veias/patologia , Veias/fisiopatologiaAssuntos
Aneurisma/cirurgia , Doenças das Artérias Carótidas/cirurgia , Aneurisma Intracraniano/cirurgia , Procedimentos Cirúrgicos Vasculares/instrumentação , Procedimentos Cirúrgicos Vasculares/métodos , Aneurisma/patologia , Angiografia Digital , Doenças das Artérias Carótidas/patologia , Embolização Terapêutica/métodos , Feminino , Humanos , Aneurisma Intracraniano/patologia , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , StentsRESUMO
Two patients with giant complex saccular aneurysms of the proximal basilar artery were managed with flow-reversal using the endovascular route. Complete obliteration of the aneurysm was successful in one patient resulting in long term survival (8 year follow-up completed). Incomplete obliteration of the aneurysm persisted in the other patient, resulting in recurrence and a fatal haemorrhage one year after treatment. Endovascular flow-reversal is a good treatment option for these lesions with a high surgical risk. However, persistent incomplete thrombosis of these aneurysms following flow-reversal should lead to the consideration of alternate treatment strategies.
Assuntos
Embolização Terapêutica/métodos , Aneurisma Intracraniano/cirurgia , Hemorragia Subaracnóidea/etiologia , Procedimentos Cirúrgicos Vasculares/métodos , Adulto , Idoso , Artéria Basilar , Evolução Fatal , Feminino , Humanos , Masculino , Recidiva , Fluxo Sanguíneo Regional , Análise de Sobrevida , Trombose , Resultado do TratamentoRESUMO
BACKGROUND: We aimed to prospectively assess the usefulness of computer tomographic angiography (CTA) in streamlining the management of symptomatic intracranial aneurysms in a tertiary neurosurgical unit, from admission to surgery. METHODS: We performed a prospective evaluation over a 2-year period of all symptomatic intracranial aneurysms managed according to a standardized departmental protocol, to assess how CTA has impacted the decision-making process pertaining to the suitability of this investigation to proceed directly to surgery. FINDINGS: A total of 90 patients with intracranial aneurysms were treated over the 2-year period. 23 (26%) underwent endovascular occlusion while 67 (74%) patients underwent a surgical clipping procedure. In the surgical group, 22 (33%) patients had their aneurysms clipped based on CTA alone, while 45 (67%) required additional conventional angiography prior to surgery. Thus around one quarter of all patients treated for symptomatic intracranial aneurysms in our unit had their aneurysm secured surgically based solely on CTA. INTERPRETATION: CTA significantly influences the acute management of symptomatic intracranial aneurysms by streamlining the decision-making process during the early and acute management of these lesions.
Assuntos
Angiografia Cerebral , Tomada de Decisões Assistida por Computador , Aneurisma Intracraniano/diagnóstico por imagem , Aneurisma Intracraniano/cirurgia , Hemorragia Subaracnóidea/diagnóstico por imagem , Hemorragia Subaracnóidea/cirurgia , Tomografia Computadorizada por Raios X , Idoso , Feminino , Humanos , Aneurisma Intracraniano/complicações , Masculino , Avaliação de Resultados em Cuidados de Saúde , Estudos Prospectivos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Hemorragia Subaracnóidea/etiologiaAssuntos
Abscesso Encefálico/cirurgia , Osso Frontal , Osteíte/cirurgia , Infecções Estreptocócicas/cirurgia , Adulto , Abscesso Encefálico/diagnóstico por imagem , Abscesso Encefálico/microbiologia , Osso Frontal/diagnóstico por imagem , Humanos , Masculino , Osteíte/microbiologia , Infecções Estreptocócicas/microbiologia , Tomografia Computadorizada por Raios XRESUMO
Anticoagulant therapy is highly effective and prevents death in more than 95% of patients who have suffered pulmonary embolism following deep vein thrombosis. Inferior vena caval filters provide an alternative to full anticoagulation in those patients at highest risk of catastrophic haemorrhagic complications. We report on two patients who developed deep vein thrombosis following ruptured unsecured intracranial aneurysms. Inferior vena caval filters were inserted prior to aneurysm clipping, as a prophylactic measure to prevent pulmonary embolism while awaiting surgery. The patients did not receive anticoagulant therapy following successful clipping of the aneurysm. Both patients had clinical resolution of the lower limb swelling and no radiological evidence of propagation of the thrombus. During 18 months of follow-up there were no complications and no evidence of post-thrombotic syndrome.
Assuntos
Aneurisma Roto/complicações , Aneurisma Intracraniano/complicações , Filtros de Veia Cava , Trombose Venosa/complicações , Aneurisma Roto/terapia , Anticoagulantes , Contraindicações , Feminino , Humanos , Aneurisma Intracraniano/terapia , Pessoa de Meia-Idade , Veia Cava Inferior , Trombose Venosa/prevenção & controleRESUMO
We report an unusual case of skull metastasis secondary to thyroid carcinoma in an adolescent girl. The 18-year-old presented with an occipital scalp swelling of 5 years' duration. She reported having thyroid surgery in mainland China 10 years previously. Radiological investigations on presentation demonstrated a lytic hypervascular skull lesion. Preoperative angiography and embolisation was followed by surgical excision. Pathological examination showed the lesion to be a thyroid carcinoma with a predominantly follicular pattern and a completion hemithyroidectomy was subsequently performed. Computed tomography of the thorax showed small micronodules in both lung fields compatible with metastases. The patient was given whole body iodine-131 internal radiation treatment and subsequently commenced thyroid-stimulating hormone-suppressive treatment with thyroxine. The management of thyroid carcinoma and subsequent skull metastasis in children and adolescents is reviewed and controversial points are highlighted.