[The certain aspects of organization of medical care of women in period of pregnancy and delivery in the Republic of Bashkortostan].

Health protection of women of reproductive age is a priority direction of state policy. In protection of reproductive health of women no small importance is played by development of organization of primary medical sanitary care and specialized medical care of women during pregnancy and delivery. The study was carried out in the Republic of Bashkortostan and covered period of 2017-2021. It was established that the number of women of fertility age decreased up to 3,9% that became one of causes of reduction of birth rate from 12.1‰ to 9.8‰ respectively. At that, the level of maternal mortality increased up to 8.9 times (from 4.1 to 36.8 per 100,000 born alive). In 2021, out of 37,775 women who completed their pregnancy, 99.3% were examined by therapist and only 92.2% passed such an examination prior to 12 weeks of their pregnancy. On the gestation period of 11-4 weeks, 91.3 % of pregnant women were subjected to ultrasound examination of fetus with detection of maternal serum markers and 94.4% of pregnant women were examined at the 19-21 weeks of pregnancy. Among pregnant women, rate of diseases and pathological conditions that preceded or developed during pregnancy slightly increased. Increasing of morbidity of anemia, diseases of endocrine system, including diabetes mellitus, was noted. The deterioration of particular indicators of organization of medical care of women according to profile "obstetrics and gynecology" occurred during period of COVID-19 pandemic. The implementation of three-level system of organization of medical care resulted in significant reduction of number of obstetric and gynecological hospital beds.

[The dynamics of demographic indices in the Republic of Bashkortostan].

The article presents results of analysis of demographic indices in the Republic of Bashkortostan. The primary data for analysis was acquired from official public statistics. The dynamics of fertility and mortality indices in 1985-2018 is described. The prognostication of indices dynamics up to 2025 was made. The distribution of mortality indices by gender, age, causes of death, place of residence is proposed for 2012, 2015 and 2018. Four periods with increasing or decreasing of fertility and mortality was allocated. The linear correlation made up to r = -0.492, p<0.01, i.e., with decreasing of birth rate increasing in mortality occurred. The assessment of dynamics of mortality in 2015-2018 established that young age groups (15-29 years old) are characterized by significant increasing of mortality in every subsequent age group as compared with previous age group. Between 2012 and 2018, total mortality decreased from 13.2 ‰ to 12.4 ‰. Males and females aged 40-44 and females aged 45-49 and 50-54 had such negative trend as increasing of mortality as compared with 2012 and 2015. The decreasing of indices of overall mortality occurred only among males. In males, mortality rate exceeded mortality rate in females up to 1.33 times in 2012, up to 1.29 times in 2015 and up to 1.23 times in 2018. The mortality rate of rural population is 1.3 times higher than mortality rate of urban population. While mortality rate of able-bodied population is 1.4 times higher. The increasing of mortality occurred due to malignant neoplasms, while the growth rate was more pronounced among rural population as compared with urban population. The mortality of respiratory diseases is more than 2 times higher in rural areas and of diseases of the digestive system is 1.5 times higher among rural population. The established growth trends in mortality among rural population due to respiratory and digestive diseases and decreasing of mortality of diseases of the circulatory system and significant decreasing of such cases as "elder age" can be explained by probability of defects in encoding of causes of death.

[The morbidity of diseases of skin and subcutaneous cellular tissue in population of the Republic of Bashkortostan].

The diseases of skin and subcutaneous tissue are an actual medical and social problem. The purpose of study was to analyze dynamics of incidence and prevalence of diseases of skin and subcutaneous tissue in population of the Republic of Bashkortostan in 2008-2017. The average rates of incidence and prevalence of these diseases in the Republic of Bashkortostan were significantly higher than relevant data in the Russian Federation and Volga federal district. In the Republic of Bashkortostan the study established increase in incidence rate of atopic dermatitis (primary morbidity increased up to 18.6%, total morbidity increased up to 20.2%) and psoriasis (total morbidity increased up to 3%). The low level of dispensary observation of patients with dermatitis in the medical organizations of the Republic of Bashkortostan was established. In 2017 full coverage with dispensary observation was established in case of children aged 0-14 years with discoid lupus erythematosus. The low level of dispensary observation of children with atopic dermatitis (42%) and adults with psoriasis (30.6%) was established. The study demonstrated necessity of further studying of total and primary morbidity of diseases of skin and subcutaneous tissue and also indices of dispensary observation of patients according nosologies and age groups, identification of corresponding risk factors, development and implementation of measures improving medical care at all stages of its rendering.

[An athrombogenic material based on modified polyethylene]. / Atrombogennyi material na osnove modifitsirovannogo poliétilena.

An athrombogenic material, exhibiting selective proteolytic activity, was developed. The material was obtained after modification of polyethylene by means of the polymer complex containing polyacrylic acid and E-caprolactam. The modified polyethylene was treated with thionyl chloride and then it was maintained in the solution containing streptokinase or urokinase. The athrombogenic material exhibited fibrinolytic activity within 15 days; its athrombogenic properties were studied in vitro.

[Clinical characteristics and morphology of Pickwickian syndrome]. / O klinike i morfologii sindroma Pikvika.

Clinical and morphological evidence obtained for 23 patients with Pickwickian syndrome has been analysed. 18 patients had no other symptoms, 12 patients died of the disease. Standard signs of the syndrome (drowsiness, respiratory distress, diffuse cyanosis, etc.) were not universal, whereas mixed-type respiratory disorders occurred in all the patients as well as right heart hypertrophy, sclerosis and hyalinosis of the lesser circulatory bed found morphologically and histologically.