1.
Chem Commun (Camb)
; 60(26): 3527-3530, 2024 Mar 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38450546
RESUMO
Nitric oxide (NO) holds promise as a cytotoxic agent against tumors, but its gaseous nature and short half-life hinder direct administration to tumor tissues. Herein, we present novel 6,9-disubstituted purine derivatives designed to ensure sustained NO release, followed by study of their significant anti-proliferative, anti-migratory, and anti-clonogenic effects on HepG2 cell lines, highlighting NO release as a potent effector for treating hepatocellular carcinoma.