RESUMO
An ideal material for repair of congenitally malformed hearts would encourage tissue regeneration with growth potential. Decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) promotes tissue regeneration in animal models and noncardiac human applications. This retrospective review evaluates SIS-ECM for reconstruction of congenital heart defects. From June 2007 to May 2009, SIS-ECM patches were used in 43 operations on 40 patients aged 2 days to 13 years. In 16 cases, the SIS-ECM was used for pericardial closure. The SIS-ECM was used for cardiac or great vessel repair in 37 cases: atrial septal defect repair in 11, pulmonary arterioplasty in 10, right ventricular outflow tract patch in 6, pulmonary monocusp valve creation in 5, superior vena cava patch in 2 and aortoplasty in 2, valve leaflet augmentation in 2, and repair of unroofed coronary sinus in 1. Follow-up was complete. There were 5 deaths, all unrelated to the SIS-ECM. Mean follow-up was 7.85 months (0.5-24 months). No pericardial effusions or intracardiac or intravascular thromboses occurred related to the SIS-ECM. The patches did not shrink or calcify. Four of 5 monocusp valves were competent and none were stenotic. One patient who underwent tricuspid valve anterior leaflet augmentation with SIS-ECM required tricuspid valve replacement 4 months later for severe regurgitation following a catheter-based procedure. Explanted tissue showed resorption of the SIS-ECM, replacement with organized collagen, and re-endothelialization. Repair of congenital heart defects using SIS-ECM is feasible and safe. In valve reconstruction, this procedure shows potential for replacement by autologous tissue. Longer-term follow-up is required to assess the potential for growth.
RESUMO
BACKGROUND: Post-transplant survival in pediatric heart transplant (HT) recipients has improved for recent era recipients. However, the era effect has not been assessed after adjusting for baseline risk factors in HT recipients. METHODS: We compared baseline characteristics and 5-year survival in pediatric HT recipients in three eras (early: July 1994 to June 1997, n = 1,153; middle: July 1997 to June 2000, n = 1,085; recent: July 2000 to June 2003, n = 1,138) for all recipients <18 years of age who were reported to the registry of the International Society for Heart and Lung Transplantation (n = 3,376). We used a Cox proportional hazards model for determining risk-adjusted era effect on death or graft loss (retransplant). RESULTS: There were more retransplants and more recipients had pre-formed antibodies in the recent eras. Recent era recipients were more likely to be supported by inotropes, ventilator, mechanical support and dialysis at the time of transplant. Five-year survival was better for patients who underwent HT in the middle era (hazard ratio [HR] 0.79, 95% confidence interval [CI] 0.68 to 0.93, p = 0.003) and the recent era (HR 0.70, CI 0.60 to 0.82, p < 0.001) as compared with those in the early era, adjusted for baseline risk factors. The determinants of conditional 5-year survival in HT recipients who survived the first 6 months were recipient and donor age, recipient gender, retransplant, pre-formed antibodies and inotropes, but not transplant era. CONCLUSIONS: Despite the worse baseline risk profile of pediatric HT recipients in recent years, their risk-adjusted survival during the first 5 years after transplant has improved. The entire era effect appears to be due to improved survival during the first 6 months post-transplant.
Assuntos
Transplante de Coração/mortalidade , Medição de Risco/métodos , Adolescente , Causas de Morte/tendências , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Lactente , Recém-Nascido , Masculino , Período Pós-Operatório , Sistema de Registros , Estudos Retrospectivos , Fatores de Risco , Taxa de Sobrevida/tendências , Fatores de TempoRESUMO
The purpose of this study was to describe the long-term outcome of infants with hypoplastic left heart syndrome (HLHS) who underwent placement of internal pulmonary artery bands as part of a transcatheter palliation procedure followed by primary heart transplantation. Transcatheter palliation included stenting of the ductus arteriosus, decompression of the left atrium by atrial septostomy, and internal pulmonary artery band placement. Cardiac hemodynamics, pulmonary artery architecture, and pulmonary artery growth since transplantation are described. Nine infants with HLHS had internal pulmonary artery bands placed and underwent successful heart transplant. No infant required reconstruction of the pulmonary arteries at the time of transplant. At 1 year after transplant, all of the recipients had normal mean pulmonary artery pressure, pulmonary vascular resistance, and transpulmonary gradient. Pulmonary angiography performed at 1 year after transplant demonstrated no distortion of pulmonary artery anatomy with significant interval growth of the branch pulmonary arteries. There was 100% survival to hospital discharge after transplant in this cohort of infants. Transcatheter placement of internal pulmonary artery bands for HLHS offers protection of the pulmonary vascular bed while preserving pulmonary artery architecture and growth with good long-term outcome.
Assuntos
Transplante de Coração , Síndrome do Coração Esquerdo Hipoplásico/cirurgia , Artéria Pulmonar/cirurgia , Angioplastia com Balão , Cateterismo Cardíaco , Feminino , Hemodinâmica , Humanos , Síndrome do Coração Esquerdo Hipoplásico/terapia , Lactente , Masculino , Cuidados Paliativos , Stents , Fatores de Tempo , Resultado do TratamentoRESUMO
OBJECTIVES: The objectives of this study are to report the spectrum of cardiac lesions in pediatric patients post-orthotopic heart transplantation (OHT), the characteristics of patients who develop these lesions, and the feasibility of transcatheter intervention in treating these lesions. BACKGROUND: Indications for OHT in the pediatric population range from cardiomyopathy to complex congenital heart defects with and without prior palliation. These patients may have residual vascular access and great vessel abnormalities. METHODS: Data was collected through retrospective review of all OHT patients at our institution from 1988 to 2005. RESULTS: During the study period, 276 heart transplants were performed. Forty-seven patients, age 1.6 [0.1-26] years with a weight of 9.5 [3.5-96.0] kilograms, underwent 69 procedures. Patients with original diagnoses of hypoplastic left heart syndrome and failed palliations required intervention most frequently. Sixteen patients, all with a history of left sided disease, developed aortic arch obstruction. Fifteen were successfully treated with balloon angioplasty while one has recurrent supravalve aortic obstruction. Fourteen patients had superior vena cava obstruction treated with balloon angioplasty and/or stent placement. Twelve patients required no further intervention and two required further stent placement. Ilio-femoral vein occlusion was treated with balloon angioplasty alone in 4 patients and stent placement in 10 patients to achieve vessel patency. Other procedures included treatment of branch pulmonary artery and pulmonary vein stenosis. CONCLUSION: Anastomotic aortic arch and venous obstructive lesions should be sought following pediatric OHT as they occur in almost 20% of patients and can be successfully addressed using interventional techniques.
Assuntos
Angioplastia Coronária com Balão , Angioplastia com Balão , Cateterismo Cardíaco , Cardiomiopatias/cirurgia , Doenças Cardiovasculares/terapia , Cardiopatias Congênitas/cirurgia , Transplante de Coração/efeitos adversos , Adolescente , Adulto , Angioplastia com Balão/instrumentação , Angioplastia Coronária com Balão/instrumentação , Doenças da Aorta/etiologia , Doenças da Aorta/terapia , Arteriopatias Oclusivas/etiologia , Arteriopatias Oclusivas/terapia , Doenças Cardiovasculares/diagnóstico por imagem , Doenças Cardiovasculares/etiologia , Criança , Pré-Escolar , Estudos de Viabilidade , Humanos , Lactente , Recém-Nascido , Cuidados Paliativos , Radiografia , Estudos Retrospectivos , Fatores de Risco , Stents , Síndrome da Veia Cava Superior/etiologia , Síndrome da Veia Cava Superior/terapia , Fatores de Tempo , Resultado do Tratamento , Trombose Venosa/etiologia , Trombose Venosa/terapia , Adulto JovemRESUMO
In three infants awaiting orthotopic cardiac transplantation, transplantation was successfully performed with the use of organs from donors who had died from cardiocirculatory causes. The three recipients had blood group O and were in the highest-risk waiting-list category. The mean age of donors was 3.7 days, and the mean time to death after withdrawal from life support was 18.3 minutes. The 6-month survival rate was 100% for the 3 transplant recipients and 84% for 17 control infants who received transplants procured through standard organ donation. The mean number of rejection episodes among the three infants during the first 6 months after surgery was 0.3 per patient, as compared with 0.4 per patient among the controls. Echocardiographic measures of ventricular size and function at 6 months were similar among the three infants and the controls (left ventricular shortening fraction, 43.6% and 44.9%, respectively; P=0.73). No late deaths (within 3.5 years) have occurred in the three infants, and they have had functional and immunologic outcomes similar to those of controls. Mortality while awaiting a transplant is an order of magnitude higher in infants than in adults, and donors who died from cardiocirculatory causes offer an opportunity to decrease this waiting-list mortality.
Assuntos
Morte , Parada Cardíaca , Transplante de Coração , Doadores de Tecidos , Obtenção de Tecidos e Órgãos/métodos , Morte Encefálica , Seguimentos , Rejeição de Enxerto/epidemiologia , Cardiopatias Congênitas/cirurgia , Transplante de Coração/métodos , Transplante de Coração/mortalidade , Humanos , Lactente , Recém-Nascido , Masculino , Prognóstico , Taxa de Sobrevida , Consentimento do Representante Legal , Fatores de Tempo , Resultado do TratamentoRESUMO
This tenth official pediatric report of the International Society for Heart and Lung Transplantation (ISHLT) covers the international pediatric lung and heart-lung transplantation experience from 1982 to 2006. As of last year's report, pediatric lung and heart-lung transplant data are now reported separately from pediatric heart transplant data and adult lung transplant data. For the first time this year, Registry data are analyzed by geographic region in addition to the usual aggregate analyses. All figures and tables included in this report and additional supplementary slides are available from the ISHLT website (www.ishlt.org/registries).
Assuntos
Transplante de Coração/estatística & dados numéricos , Transplante de Coração-Pulmão/estatística & dados numéricos , Transplante de Pulmão/estatística & dados numéricos , Sistema de Registros/estatística & dados numéricos , Sociedades Médicas , Adolescente , Criança , Pré-Escolar , Transplante de Coração/efeitos adversos , Transplante de Coração/mortalidade , Transplante de Coração-Pulmão/efeitos adversos , Transplante de Coração-Pulmão/mortalidade , Humanos , Lactente , Recém-Nascido , Agências Internacionais , Estimativa de Kaplan-Meier , Transplante de Pulmão/efeitos adversos , Transplante de Pulmão/mortalidade , Avaliação de Resultados em Cuidados de SaúdeRESUMO
CONTEXT: Although beta-blockers improve symptoms and survival in adults with heart failure, little is known about these medications in children and adolescents. OBJECTIVE: To prospectively evaluate the effects of carvedilol in children and adolescents with symptomatic systemic ventricular systolic dysfunction. DESIGN, SETTING, AND PARTICIPANTS: A multicenter, randomized, double-blind, placebo-controlled study of 161 children and adolescents with symptomatic systolic heart failure from 26 US centers. In addition to treatment with conventional heart failure medications, patients were assigned to receive placebo or carvedilol. Enrollment began in June 2000 and the last dose was given in May 2005 (each patient received medication for 8 months). INTERVENTIONS: Patients were randomized in a 1:1:1 ratio to twice-daily dosing with placebo, low-dose carvedilol (0.2 mg/kg per dose if weight <62.5 kg or 12.5 mg per dose if weight > or =62.5 kg), or high-dose carvedilol (0.4 mg/kg per dose if weight <62.5 kg or 25 mg per dose if weight > or =62.5 kg) and were stratified according to whether each patient's systemic ventricle was a left ventricle or not. MAIN OUTCOME MEASURES: The primary outcome was a composite measure of heart failure outcomes in patients receiving carvedilol (low- and high-dose combined) vs placebo. Secondary efficacy variables included individual components of this composite, echocardiographic measures, and plasma b-type natriuretic peptide levels. RESULTS: There was no statistically significant difference between groups for the composite end point based on the percentage of patients who improved, worsened, or were unchanged. Among 54 patients assigned to placebo, 30 improved (56%), 16 worsened (30%), and 8 were unchanged (15%); among 103 patients assigned to carvedilol, 58 improved (56%), 25 worsened (24%), and 20 were unchanged (19%). The rates of worsening were lower than expected. The odds ratio for worsened outcome for patients in the combined carvedilol group vs the placebo group was 0.79 (95% CI, 0.36-1.59; P = .47). A prespecified subgroup analysis noted significant interaction between treatment and ventricular morphology (P = .02), indicating a possible differential effect of treatment between patients with a systemic left ventricle (beneficial trend) and those whose systemic ventricle was not a left ventricle (nonbeneficial trend). CONCLUSIONS: These preliminary results suggest that carvedilol does not significantly improve clinical heart failure outcomes in children and adolescents with symptomatic systolic heart failure. However, given the lower than expected event rates, the trial may have been underpowered. There may be a differential effect of carvedilol in children and adolescents based on ventricular morphology. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00052026.
Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Carbazóis/uso terapêutico , Baixo Débito Cardíaco/tratamento farmacológico , Propanolaminas/uso terapêutico , Disfunção Ventricular/complicações , Adolescente , Antagonistas Adrenérgicos beta/sangue , Carbazóis/sangue , Baixo Débito Cardíaco/sangue , Baixo Débito Cardíaco/etiologia , Carvedilol , Criança , Pré-Escolar , Método Duplo-Cego , Feminino , Humanos , Lactente , Masculino , Peptídeo Natriurético Encefálico/sangue , Propanolaminas/sangue , Modelos de Riscos Proporcionais , Estudos Prospectivos , Sístole , Remodelação Ventricular/efeitos dos fármacosRESUMO
BACKGROUND: Control of distal pulmonary artery (PA) pressure and flow is a critical step in palliating infants with complex congential heart disease. Surgical procedures to protect or isolate the pulmonary circulation carry significant risk and can be unpredictable. Interventional control of pulmonary pressure/flow with an intravascular device (band) could reduce risk and improve regulation of pulmonary flow. METHODS: Internal pulmonary bands were created from woven nitinol to create an internal orifice estimated to reduce distal pulmonary arterial pressure by 50%. Two designs were tested, a single eccentric lumen and two symmetrical lumens. The devices were approximately 7-mm long and the external diameter varied to suit the pulmonary arterial lumen size. A total of 15 devices were implanted in seven lambs with a stented ductus arteriosus to create high pulmonary pressure/flow. Four lambs were followed with devices and stent in place for a mean of 37 +/- 13 days. RESULTS: Fourteen of 15 devices were successfully implanted. One was acutely removed since the size was too large. Both device designs created greater than a 50% reduction in distal pulmonary pressure. Main PA pressure was 70/38, mean 50 +/- 13 mm Hg, and distal PA pressure 25/16, mean 20 +/- 7 mm Hg (P < 0.05). Angiography demonstrated protection of the internal banded pulmonary segments from overcirculation. Late follow-up showed that the device lumen(s) remained patent. Histology showed the vessel media to be intact but there was intimal proliferation where the device approximated the wall. There were no thrombotic emboli detected. CONCLUSION: Percutaneous internal banding of the pulmonary arteries was feasible and successful in lambs with high pulmonary flow/pressure analogous to infants with complex congenital heart disease.
Assuntos
Pressão Sanguínea , Cardiopatias Congênitas/complicações , Hipertensão Pulmonar/cirurgia , Artéria Pulmonar/cirurgia , Circulação Pulmonar , Procedimentos Cirúrgicos Vasculares/instrumentação , Ligas , Angiografia , Animais , Animais Recém-Nascidos , Cateterismo Cardíaco , Modelos Animais de Doenças , Canal Arterial/cirurgia , Desenho de Equipamento , Estudos de Viabilidade , Cardiopatias Congênitas/fisiopatologia , Cardiopatias Congênitas/cirurgia , Hipertensão Pulmonar/etiologia , Hipertensão Pulmonar/patologia , Hipertensão Pulmonar/fisiopatologia , Artéria Pulmonar/patologia , Artéria Pulmonar/fisiopatologia , Ovinos , Stents , Fatores de Tempo , Grau de Desobstrução VascularRESUMO
BACKGROUND: Desmin-related myofibrillar myopathy (DRM) is a cardiac and skeletal muscle disease caused by mutations in the desmin (DES) gene. Mutations in the central 2B domain of DES cause skeletal muscle disease that typically precedes cardiac involvement. However, the prevalence of DES mutations in dilated cardiomyopathy (DCM) without skeletal muscle disease is not known. METHODS AND RESULTS: Denaturing high-performance liquid chromatography was used to screen DES for mutations in 116 DCM families from the Familial Dilated Cardiomyopathy Registry and in 309 subjects with DCM from the Beta-Blocker Evaluation of Survival Trial (BEST). DES mutations were transfected into SW13 and human smooth muscle cells and neonatal rat cardiac myocytes, and the effects on cytoskeletal desmin network architecture were analyzed with confocal microscopy. Five novel missense DES mutations, including the first localized to the highly conserved 1A domain, were detected in 6 subjects (1.4%). Transfection of DES mutations in the 2B domain severely disrupted the fine intracytoplasmic staining of desmin, causing clumping of the desmin protein. A tail domain mutation (Val459Ile) showed milder effects on desmin cytoplasmic network formation and appears to be a low-penetrant mutation restricted to black subjects. CONCLUSIONS: The prevalence of DES mutations in DCM is between 1% and 2%, and mutations in the 1A helical domain, as well as the 2B rod domain, are capable of causing a DCM phenotype. The lack of severe disruption of cytoskeletal desmin network formation seen with mutations in the 1A and tail domains suggests that dysfunction of seemingly intact desmin networks is sufficient to cause DCM.
Assuntos
Cardiomiopatia Dilatada/genética , Desmina/genética , Mutação/genética , Adulto , Idoso , Animais , Cardiomiopatia Dilatada/diagnóstico , Cardiomiopatia Dilatada/epidemiologia , Células Cultivadas , Estudos de Coortes , Desmina/biossíntese , Feminino , Expressão Gênica , Genes Dominantes , Triagem de Portadores Genéticos , Testes Genéticos , Humanos , Masculino , Microscopia de Fluorescência , Pessoa de Meia-Idade , Miócitos Cardíacos/metabolismo , Miócitos Cardíacos/patologia , Fenótipo , Prevalência , Ratos , Sistema de Registros , Transfecção , Estados Unidos/epidemiologiaRESUMO
BACKGROUND: Since the initial utilization of heart transplantation as therapy for end-stage pediatric heart disease, improvements have occurred in outcomes with heart transplantation and surgical therapies for congenital heart disease along with the application of medical therapies to pediatric heart failure that have improved outcomes in adults. These events justify a reevaluation of the indications for heart transplantation in congenital heart disease and other causes of pediatric heart failure. METHODS AND RESULTS: A working group was commissioned to review accumulated experience with pediatric heart transplantation and its use in patients with unrepaired and/or previously repaired or palliated congenital heart disease (children and adults), in patients with pediatric cardiomyopathies, and in pediatric patients with prior heart transplantation. Evidence-based guidelines for the indications for heart transplantation or retransplantation for these conditions were developed. CONCLUSIONS: This evaluation has led to the development and refinement of indications for heart transplantation for patients with congenital heart disease and pediatric cardiomyopathies in addition to indications for pediatric heart retransplantation.
Assuntos
American Heart Association , Cardiopatias/cirurgia , Transplante de Coração , Enfermagem , Avaliação de Resultados em Cuidados de Saúde , Fatores Etários , Cardiologia/métodos , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/cirurgia , Procedimentos Cirúrgicos Cardiovasculares , Criança , Diretrizes para o Planejamento em Saúde , Cardiopatias/epidemiologia , Humanos , Estados UnidosAssuntos
Transplante de Coração/estatística & dados numéricos , Sistema de Registros , Adolescente , Adulto , Idoso , Causas de Morte , Criança , Feminino , Transplante de Coração/efeitos adversos , Transplante de Coração/mortalidade , Humanos , Terapia de Imunossupressão , Internacionalidade , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Fatores de Risco , Taxa de SobrevidaAssuntos
Transplante de Coração-Pulmão/estatística & dados numéricos , Transplante de Pulmão/estatística & dados numéricos , Sistema de Registros , Adolescente , Adulto , Idoso , Causas de Morte , Feminino , Transplante de Coração-Pulmão/efeitos adversos , Transplante de Coração-Pulmão/mortalidade , Humanos , Terapia de Imunossupressão , Internacionalidade , Transplante de Pulmão/efeitos adversos , Transplante de Pulmão/mortalidade , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Fatores de Risco , Taxa de SobrevidaAssuntos
Transplante de Coração/estatística & dados numéricos , Sistema de Registros , Adolescente , Causas de Morte , Criança , Pré-Escolar , Feminino , Transplante de Coração/efeitos adversos , Transplante de Coração/mortalidade , Humanos , Terapia de Imunossupressão , Lactente , Internacionalidade , Masculino , Complicações Pós-Operatórias/epidemiologia , Fatores de Risco , Taxa de SobrevidaAssuntos
Transplante de Coração-Pulmão/estatística & dados numéricos , Transplante de Pulmão/estatística & dados numéricos , Sistema de Registros , Adolescente , Causas de Morte , Criança , Pré-Escolar , Transplante de Coração-Pulmão/efeitos adversos , Transplante de Coração-Pulmão/mortalidade , Humanos , Terapia de Imunossupressão , Lactente , Internacionalidade , Transplante de Pulmão/efeitos adversos , Transplante de Pulmão/mortalidade , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Taxa de SobrevidaRESUMO
BACKGROUND: Tissue Doppler imaging (TDI), a non-invasive echocardiography technique, permits quantitative analysis of the regional distribution pattern of myocardial velocities. During normal childhood development, regional function changes markedly, including an increasing predominance of longitudinal velocities. This study analyzed the impact of heart transplantation on ventricular mechanics in growing children. METHODS: TDI was performed in 30 pediatric heart transplant recipients (7.1 +/- 6.2 years) and 32 age-matched healthy children (6.8 +/- 5.4 years). Patients had no rejection history and were 3.1 years (median) post-transplant. Color TDI images from apical and parasternal views were stored as echocardiographic raw data. Off-line analysis was used to measure peak systolic and diastolic myocardial velocities in 6 basal cardiac segments for longitudinal (anterior, inferior, lateral, septal, right ventricle) and radial velocities (posterior). Isovolumic acceleration, a load-insensitive function marker, was determined as slope of the upstroke of the isovolumic contraction wave. Multiple regression modeling was used for statistics. RESULTS: Systolic myocardial velocities still increased with age after transplantation, but the velocity distribution pattern was changed. In transplanted hearts, left ventricular longitudinal velocities were lower and radial velocities were higher than in the controls, but isovolumic acceleration was similar. In the right ventricle, longitudinal velocities and isovolumic acceleration were significantly decreased after transplantation. Wall motion abnormalities were present in 50% of patients. CONCLUSIONS: Regional wall motion analysis shows significant alterations of the fundamental biomechanical pump function of the left ventricle after heart transplantation in children, with a shift from longitudinal to radial fibers and depressed right ventricular wall motion. This may have important implications for the long-term graft function required in children.