Evaluation of Trabecular Bone Microarchitecture and Bone Mineral Density in Young Women, Including Selected Hormonal Parameters.

The absence of non-invasive methods for assessing bone material and structural changes is a significant diagnostic challenge. Dual-energy X-ray absorptiometry (DXA) bone mineral density (BMD) testing is the gold standard for osteoporosis diagnosis. BMD and the trabecular bone score (TBS) have facilitated targeted osteoporosis prevention and treatment in clinical settings. The findings from this study indicate that BMD modulation in young women is influenced by various hormones, potentially compromising the diagnostic precision of BMD for subclinical bone demineralization. A total of 205 women aged 19 to 37 underwent anthropometric measurements and hormonal tests. BMD was determined using DXA, and TBS values were computed from the lumbar spine L1-L4 segment. The multivariate analysis findings suggest that BMD might not be determined by hormones. The relationship between TBS and TSH was statistically significant in the univariate analysis, which indicates the efficacy of further studies to determine the link between TBS and specific hormones. Analyzing the strength of the correlation between TBS and hormones in the univariate analysis shows which factors are worth considering in further analyses. This makes it possible to create better techniques that will help identify young women who are at a higher risk of developing osteoporosis.

Analysis of the Occurrence of Predicative Factors of Chronic Fatigue in Female Patients with Cancer of the Reproductive Organs with Respect to Stage of Treatment.

The aim of this study was to search for mechanisms contributing to cancer-related fatigue in patients with gynecologic cancer. The study involved 51 women with advanced endometrial cancer and ovarian cancer undergoing chemotherapy. Data were gathered at four points in time. After giving consent, each of the women had their blood drawn several times (before surgery and the first, third, and sixth cycle of chemotherapy) to determine serum levels of pro- and anti-inflammatory cytokines. Empirical data were collected using the MFSI-SF and an original questionnaire. Cancer-related fatigue (CRF) was present at every stage of treatment, but the highest mean scores were noted before cytoreductive surgery (8.745 ± 4.599), and before the sixth cycle of chemotherapy (9.667 ± 4.493). Statistically significant relationships were found between IL-1α, IL-1ß, IL-2, Il-6, and IL-10 and fatigue at different stages of treatment. Older age and an above-normal BMI were the major prerequisite factors for the occurrence of fatigue in female oncological patients. The analysis of changes in cytokine levels and the severity of fatigue may be used to improve our understanding of cancer-related fatigue, and to take action to alleviate the obtrusive symptoms experienced by female patients with cancer of the reproductive organs.

The Significance of Adaptation and Coping with Disease among Patients with Diagnosed Gynaecological Cancer in the Context of Disease Acceptance.

Uterine/endometrial and ovarian tumours are among the most common gynaecological cancers. Adaptation to cancer encompasses a variety of complex behavioural, cognitive, and emotional processes. The purpose of mental adaptation is to alleviate emotional discomfort and regain mental stability. The aim of the study was to assess the influence of adaptation and coping with gynaecological cancer on the level of disease acceptance among the studied women. The study included 81 patients diagnosed with gynaecological cancer. Mental adaptation to cancer was measured using the Min-Mac scale, disease acceptance was measured using the AIS and the level of adaptation was measured using the CAPS. The average AIS score was 26.65 ± 8.85 points. Adaptation and coping methods did not vary significantly depending on the diagnosed type of cancer. The constructive style of fighting the disease prevailed (45.11 ± 6.01). The AIS scores correlated significantly and positively with the intensity of the constructive style of mental adaptation, and negatively with the intensity of the destructive style. The studied group of patients with gynaecological cancer displayed a moderate level of disease acceptance, the constructive style of adaptation was the most prevalent, and the location of the cancer did not have an effect on coping mechanisms.

Clinical Relevance of Soluble Forms of Immune Checkpoint Molecules sPD-1, sPD-L1, and sCTLA-4 in the Diagnosis and Prognosis of Ovarian Cancer.

It is crucial to find new diagnostic and prognostic biomarkers. A total of 80 patients were enrolled in the study. The study group consisted of 37 patients with epithelial ovarian cancer, and the control group consisted of 43 patients with benign ovarian cystic lesions. Three proteins involved in the immune response were studied: PD-1, PD-L1, and CTLA-4. The study material was serum and peritoneal fluid. The ROC curve was plotted, and the area under the curve was calculated to characterize the sensitivity and specificity of the studied parameters. Univariate and multivariate analyses were performed simultaneously using the Cox regression model. The cut-off level of CTLA-4 was 0.595 pg/mL, with the sensitivity and specificity of 70.3% and 90.7% (p = 0.000004). Unfavorable prognostic factors determined in serum were: PD-L1 (for PFS: HR 1.18, 95% CI 1.11-1.21, p = 0.016; for OS: HR 1.17, 95% CI 1.14-1.19, p = 0.048) and PD-1 (for PFS: HR 1.01, 95% CI 0.91-1.06, p = 0.035). Unfavorable prognostic factors determined in peritoneal fluid were: PD-L1 (for PFS: HR 1.08, 95% CI 1.01-1.11, p = 0.049; for OS: HR 1.14, 95% CI 1.10-1.17, p = 0.045) and PD-1 (for PFS: HR 1.21, 95% CI 1.19-1.26, p = 0.044). We conclude that CTLA-4 should be considered as a potential biomarker in the diagnosis of ovarian cancer. PD-L1 and PD-1 concentrations are unfavorable prognostic factors for ovarian cancer.

Rhabdomyosarcoma of the Cervix in a Post-Menopausal Woman-An Unparalleled Phenomenon.

Rhabdomyosarcoma of the cervix is a soft tissue sarcoma that usually occurs in young women. It is very rare in adulthood. We discuss symptoms, the process of diagnosis of rhabdomyosarcoma embryonale of the cervix in a 61-year-old women and differences in treatment dependent on patient's age. A 61-year-old woman with symptoms such as palpable mass in the external cervical opening and post-menopausal hemorrhaging was admitted to the oncology ward where excision of the polyp was performed. Embryonal rhabdomyosarcoma (ERMS) was diagnosed by histopathological examination of obtained tissues. The diagnosis was complemented by chest computed tomography and pelvis magnetic resonance imaging to exclude metastases. A Wertheim-Meigs operation and excision of the ovaries, the fallopian tubes and the surrounding tissue was performed in the course of treatment. In the patient's follow-up of 25 months to date, there have been no signs of recurrence or symptoms connected to ERMS. Based on the therapeutic outcome, the decision to limit the treatment to a surgical resection was adequate for a post-menopausal patient. Because of the rarity of ERMS in the post-menopausal age, we think that the patient should be carefully followed up to further examine this issue and develop diagnostic and treatment guidelines.

Sexual and Life Satisfaction of Pregnant Women.

The awareness of one's own sexuality and its expression depend on the stage of an individual's life. Pregnancy is a period of many, also psychosexual, changes. The sexual needs of pregnant women are rarely discussed, and intercourse during this period seems to be a taboo. The aim of this study was to assess the sexual and life satisfaction of pregnant women. The study involved 181 pregnant women and was conducted from July to November 2018. The participants were patients of the pregnancy pathology ward, Independent Public Clinical Hospital No. 2 in Szczecin, and participants of antenatal classes. The research project was approved by the Bioethics Committee of the Pomeranian Medical University, Szczecin (KB-0012/74/18). This survey-based study was performed using the self-developed questionnaire and standardized tools: the Sexual Satisfaction Questionnaire, and the Satisfaction with Life Scale (SWLS). Statistical analysis was performed using the SPSS Statistics 24.0 statistical package. The tests used were the Kolmogorov-Smirnov test, the Shapiro-Wilk test, and Pearson's test. The statistical significance of the results was assumed as (p < 0.05), the correlations (p < 0.01), and probability (p < 0.001). This study demonstrated a high level of life satisfaction, a medium level of overall sexual satisfaction, and a high level of satisfaction with sex. A higher level of satisfaction with life was associated with higher levels of sexual satisfaction in every dimension. There is a need for comprehensive perinatal care and professional sexual counseling.

Is copeptin a new potential biomarker of insulin resistance in polycystic ovary syndrome?

O: BJECTIVES: Copeptin has been reported to play an important role in metabolic response in women with PCOS. However, the optimal cut-off value for detecting subjects with insulin resistance (IR) remains undetermined. We investigated whether copeptin can serve as an indicator of IR and tried to determine the optimal cut-off value of plasma copeptin concentration in detecting subjects with PCOS and IR. MATERIAL AND METHODS: We carried out a case-control study on 158 women with PCOS and HOMA-IR < 2.5, 96 women with PCOS with HOMA-IR ≥ 2.5, and 70 healthy volunteers. Plasma copeptin, as well as hormonal, biochemical, metabolic, and IR parameters, were measured. To investigate whether copeptin allows IR to be predicted in PCOS, we used logistic regression models and ROC curve analysis. RESULTS: Median plasma copeptin concentration was the highest in the women with PCOS and HOMA-IR ≥ 2.5. Logistic regression analysis revealed that copeptin was the strongest predictor of HOMA ≥ 2.5 (OR: 53.34 CI 7.94-358.23, p < 0.01). Analysis of ROC curves indicated that the cut-off value above 4 pmol/L of plasma copeptin concentration had high (99%) specificity but very low (21%) sensitivity in diagnosing of IR (AUC 0.607 (95% CI 0.53-0.68. CONCLUSIONS: Our findings suggest that copeptin is associated with IR in PCOS patients, but due to low sensitivity should not be considered as a marker of IR.

[The assessment of anxiety in pregnant women in respect of biological, medical and socio-environmental factors].

Introduction: Anxiety in the perinatal period may lead to serious complications resulting in the pathological course of pregnancy, fear and disturbances of delivery, and postnatal emotional problems. The latter, if unsolved in this period, may contribute to the worsening of relations between partners, between a mother and a child, and within a family. They also deteriorate the psychological well -being of a woman. This thesis was aimed at assessing the occurrence of anxiety in pregnant women throughout each pregnancy trimester, and attempting to explain its biological, medical and social -environmental determinants. Material and methods: The material for this prospective longitudinal study consisted of 181 pregnant residents of Szczecin. Each woman was examined three times during pregnancy, once in each trimester. The research instruments were: a questionnaire of the author's own design and a standardized instrument ­ Spielberger's State -Trait Anxiety Inventory (STAI). Conclusions: 1. Anxiety level in the course of pregnancy is lowest in the second trimester. 2. In those women who during pregnancy complained of discomfort or worsened mood, and in those who experienced problems with sleeping, higher intensity of anxiety is noted throughout the whole period of pregnancy. 3. Such factors as unintended pregnancy, lack of family support, and disapproval of pregnancy by a partner or the community are associated with suffering from aggravated anxiety in each trimester of pregnancy. 4. Women who have a negative judgement of their housing situation and ô€inancial standing are at risk of high levels of anxiety throughout the whole pregnancy. 5. Perinatal education is connected with signiô€icantly lesser occurrence of anxiety in each trimester of pregnancy. 6. Failure to have a preventive medical examination prior to pregnancy (woman, man) is related to experiencing signiô€icantly higher level of anxiety in the ô€irst and third trimesters of pregnancy.

Reasons for giving up breastfeeding and support during problems with lactation in the north-western part of Poland.

INTRODUCTION: Breastfeeding is the optimal way of feeding for neonates and infants. Its duration is of vital importance for the child's development and health. The World Health Organization recommends exclusive breastfeeding until the end of the sixth month of life. Many mothers give up breastfeeding earlier than recommended. Professional and non-professional support plays a great role in motivation to start and continue breastfeeding. The aim of this study was to determine how long infants from Szczecin, the capital city of the North-Western region of Poland, are breastfed, what are the reasons for giving up breastfeeding, and whether mothers obtain support in case of problems with lactation. METHODS: One hundred randomly chosen mothers with children aged 12-18 months, living in Szczecin, were examined. A questionnaire was administered to the mothers during a direct interview. Prior to the interview, consent of the mothers to participate in the study was obtained. RESULTS: More than 8% of the mothers gave up breastfeeding during the first month after delivery, 68% were breastfeeding till the end of the third month, 31.5% were breastfeeding till the end of the sixth month, and only 2% continued to breastfeed for one year or longer. The most frequent reasons for giving up breastfeeding were: return to work (43.4%), small volume of milk (29.3%) and child's reluctance to suck (18.5%). 62% of breastfeeding women benefited from support during lactation problems but only 6% visited an outpatient breastfeeding service or joined a breastfeeding mothers support group. Support was obtained from the family midwife (37%), pediatrician (32%), and midwife at an outpatient clinic (25.8%). Most women (74.2%) were satisfied with the support. CONCLUSIONS: (1) It is necessary to promote breastfeeding so that all women could decide to start breastfeeding after childbirth. 2. As the percentage of women who continue breastfeeding after the sixth month of the infant's life is unsatisfactory, mothers should be encouraged to breastfeed longer. (3) A system of professional lactation support for breastfeeding mothers should be developed.

[Women's opinions regarding gynaecological examination in a hospital]. / Opinie kobiet na temat badania ginekologicznego w szpitalu.

A visit to the gynaecologist is connected with considerable embarrassment and stress for most women. AIM OF THE RESEARCH: To ascertain patients' opinions about gynaecological examination, frequency of visits, and doctors' attitudes towards patients. MATERIAL AND METHODS: A hundred women from Western-Pomeranian region underwent an anonymous examination. The women were divided into three age groups: 20-40, 41-60 and 61+. The study was carried out in two hospital clinics of the Pomeranian Medical University: the Clinic of Procreation and Gynaecology and the Clinic of Obstetric and Gynaecology, between 2006-2007. RESULTS: 70% of the respondents find the gynaecological examination embarrassing and stressful. According to patients, the most unpleasant moment during their visit to the gynaecologist is time spent in the gynaecological chair (47%) and preparation for the examination (30%), whereas the least embarrassing moment is the gynaecological examination itself (21%). However, the most embarrassing moment of the examination is vaginal examination (40%), rectal examination (33%), colposcopy (27%), and breast examination (2%). All the women stated that gynaecological examination is necessary; with 40% of them having examinations once every twelve months, 32% once every six months, 9% once every twenty-four months and 19% even more seldom. Sense of safety and psychical comfort during the examination is ensured by the presence of a qualified midwife (46%), presence of another doctor (9%), privacy (only the doctor and the patient are present) (36%). 53% of the respondents stated that the doctor ensures intimacy during the examination and 47% gave negative answer. Analysis of the doctor's gender indicated that 56% women prefer to be examined by a woman, 37% by a man, and 7% find the gender to be of no importance. The respondents would prefer if the doctor were nice, good-tempered and communicative. CONCLUSIONS: (1) Gynaecological examination is embarrassing and stressful for women and that is why patients expect the gynaecologist to ensure intimacy and sense of safety during the examination, as well as a pleasant individual approach to a patient, and presence of a midwife. (2) The most embarrassing moment is climbing to the gynaecological chair and the most unpleasant moment is the vaginal examination. (3) The fact that women go to the gynaecologist so rarely is particularly worrisome.

[Self-care and demand for social support in women with infertility]. / Ocena mozliwosci samoopieki i zapotrzebowania na zródla wsparcia spolecznego u kobiet z problemem nieplodnosci.

INTRODUCTION: The prevalence of infertility among married couples is growing. It is estimated that every fifth married couple in Poland is infertile. Infertility is often a source of significant stress for the spouses. It is therefore important to provide professional support, demonstrate interest, listen to the problem, and be present in difficult moments. Social support considerably reduces the feeling of abandonment, fosters self-care, accelerates recovery, strengthens coping, and helps modify views and habits or attitudes towards treatment. The aim of this study was to assess self-care in women with infertility and to identify the most common sources of social support. MATERIAL AND METHODS: The study group consisted of 100 women diagnosed or treated for infertility at the Department of Reproduction and Gynecology, Pomeranian Medical University in Szczecin. The diagnostic poll was done with the aid of a standardised research tool--the Social Support Scale Questionnaire by Danuta Zarzycka. The study protocol was approved by the Bioethics Committee of the Pomeranian Medical University. The study was performed between July 2005 and March 2007. CONCLUSIONS: (1) Self-care in women with infertility is adequate. (2) Women with infertility usually expect professional support from a physician; the role of the nurse is undervalued. Thus, the role of the nurse and midwife needs further promotion.