RESUMO
Adolescence is a timed process with an onset, tempo, and duration. Nevertheless, the temporal dimension, especially the pace of maturation, remains an insufficiently studied aspect of developmental progression. The primary objective is to estimate the precise influence of pubertal maturational tempo on the configuration of associative brain regions. To this end, the connection between maturational stages and the level of hierarchical organization of large-scale brain networks in 12-13-year-old females is analyzed. Skeletal maturity is used as a proxy for pubertal progress. The degree of maturity is defined by the difference between bone age and chronological age. To assess the level of hierarchical organization in the brain, the temporal dynamic of closed eye resting state high-density electroencephalography (EEG) in the alpha frequency range is analyzed. Different levels of hierarchical order are captured by the measured asymmetry in the directionality of information flow between different regions. The calculated EEG-based entropy production of participant groups is then compared with accelerated, average, and decelerated maturity. Results indicate that an average maturational trajectory optimally aligns with cerebral hierarchical order, and both accelerated and decelerated timelines result in diminished cortical organization. This suggests that a "Goldilocks rule" of brain development is favoring a particular maturational tempo.
Assuntos
Encéfalo , Eletroencefalografia , Puberdade , Humanos , Feminino , Eletroencefalografia/métodos , Adolescente , Criança , Encéfalo/fisiologia , Encéfalo/crescimento & desenvolvimento , Puberdade/fisiologiaRESUMO
PURPOSE: Accumulating evidence from epidemiological studies that pediatric computed tomography (CT) examinations can be associated with a small but non-zero excess risk for developing leukemia or brain tumor highlights the need to optimize doses of pediatric CT procedures. Mandatory dose reference levels (DRL) can support reduction of collective dose from CT imaging. Regular surveys of applied dose-related parameters are instrumental to decide when technological advances and optimized protocol design allow lower doses without sacrificing image quality. Our aim was to collect dosimetric data to support adapting current DRL to changing clinical practice. METHOD: Dosimetric data and technical scan parameters from common pediatric CT examinations were retrospectively collected directly from Picture Archiving and Communication Systems (PACS), Dose Management Systems (DMS), and Radiological Information Systems (RIS). RESULTS: We collected data from 17 institutions on 7746 CT series from the years 2016 to 2018 from examinations of the head, thorax, abdomen, cervical spine, temporal bone, paranasal sinuses and knee in patients below 18 years of age. Most of the age-stratified parameter distributions were lower than distributions from previously-analyzed data from before 2010. Most of the third quartiles were lower than German DRL at the time of the survey. CONCLUSIONS: Directly interfacing PACS, DMS, and RIS installations allows large-scale data collection but relies on high data-quality at the documentation stage. Data should be validated by expert knowledge or guided questionnaires. Observed clinical practice in pediatric CT imaging suggests lowering some DRL in Germany is reasonable.
Assuntos
Tomografia Computadorizada por Raios X , Criança , Humanos , Doses de Radiação , Estudos Retrospectivos , Tomografia Computadorizada por Raios X/métodos , Inquéritos e Questionários , Alemanha/epidemiologia , Valores de ReferênciaRESUMO
The Locus coeruleus (LC) modulates various neuronal circuits throughout the brain. Its unique architectural organization encompasses a net of axonal innervation that spans the entire brain, while its somatic core is highly compact. Recent research revealed an unexpected cellular input specificity within the nucleus that can give rise to various network states that either broadcast norepinephrine signals throughout the brain or pointedly modulate specific brain areas. Such adaptive input-output functions likely surpass our existing network models that build upon a given synaptic wiring configuration between neurons. As the distances between noradrenergic neurons in the core of the LC are unusually small, neighboring neurons could theoretically impact each other via volume transmission of NE. We therefore set out to investigate if such interaction could be mediated through noradrenergic alpha2-receptors in a spiking neuron model of the LC. We validated our model of LC neurons through comparison with experimental patch-clamp data and identified key variables that impact alpha2-mediated inhibition of neighboring LC neurons. Our simulation confirmed a reliable autoinhibition of LC neurons after episodes of high neuronal activity that continue even after neuronal activity subsided. Additionally, dendro-somatic synapses inhibited spontaneous spiking in the somatic compartment of connected neurons in our model. We determined the exact position of hundreds of LC neurons in the mouse brain stem via a tissue clearing approach and, based on this, further determined that 25 percent of noradrenergic neurons have a neighboring LC neuron within less than a 25-micrometer radius. By modeling NE diffusion, we estimated that more than 15 percent of the alpha2-adrenergic receptors fraction can bind NE within such a diffusion radius. Our spiking neuron model of LC neurons predicts that repeated or long-lasting episodes of high neuronal activity induce partitioning of the gross LC network and reduce the spike rate in neighboring neurons at distances smaller than 25 µm. As these volume-mediating neighboring effects are challenging to test with the current methodology, our findings can guide future experimental approaches to test this phenomenon and its physiological consequences.
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The numerous multistable phenomena in vision, hearing and touch attest that the inner workings of perception are prone to instability. We investigated a visual example-binocular rivalry-with an accurate no-report paradigm, and uncovered developmental and maturational lifespan trajectories that were specific for age and sex. To interpret these trajectories, we hypothesized that conflicting objectives of visual perception-such as stability of appearance, sensitivity to visual detail, and exploration of fundamental alternatives-change in relative importance over the lifespan. Computational modelling of our empirical results allowed us to estimate this putative development of stability, sensitivity, and exploration over the lifespan. Our results confirmed prior findings of developmental psychology and appear to quantify important aspects of neurocognitive phenotype. Additionally, we report atypical function of binocular rivalry in autism spectrum disorder and borderline personality disorder. Our computational approach offers new ways of quantifying neurocognitive phenotypes both in development and in dysfunction.
Assuntos
Desenvolvimento do Adolescente , Desenvolvimento Infantil , Visão Ocular , Vias Visuais/fisiologia , Percepção Visual , Adolescente , Adulto , Fatores Etários , Idoso , Criança , Cognição , Feminino , Humanos , Longevidade , Masculino , Pessoa de Meia-Idade , Modelos Teóricos , Caracteres Sexuais , Visão Binocular , Adulto JovemRESUMO
In ambiguous or conflicting sensory situations, perception is often 'multistable' in that it perpetually changes at irregular intervals, shifting abruptly between distinct alternatives. The interval statistics of these alternations exhibits quasi-universal characteristics, suggesting a general mechanism. Using binocular rivalry, we show that many aspects of this perceptual dynamics are reproduced by a hierarchical model operating out of equilibrium. The constitutive elements of this model idealize the metastability of cortical networks. Independent elements accumulate visual evidence at one level, while groups of coupled elements compete for dominance at another level. As soon as one group dominates perception, feedback inhibition suppresses supporting evidence. Previously unreported features in the serial dependencies of perceptual alternations compellingly corroborate this mechanism. Moreover, the proposed out-of-equilibrium dynamics satisfies normative constraints of continuous decision-making. Thus, multistable perception may reflect decision-making in a volatile world: integrating evidence over space and time, choosing categorically between hypotheses, while concurrently evaluating alternatives.
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Tomada de Decisões , Dominância Ocular , Visão Binocular , Percepção Visual , Feminino , Humanos , MasculinoRESUMO
Humans and others primates are highly attuned to temporal consistencies and regularities in their sensory environment and learn to predict such statistical structure. Moreover, in several instances, the presence of temporal structure has been found to facilitate procedural learning and to improve task performance. Here we extend these findings to visual object recognition and to presentation sequences in which mutually predictive objects form distinct clusters or "communities." Our results show that temporal community structure accelerates recognition learning and affects the order in which objects are learned ("onset of familiarity").
Assuntos
Percepção de Forma/fisiologia , Modelos Teóricos , Reconhecimento Visual de Modelos/fisiologia , Prática Psicológica , Aprendizagem por Probabilidade , Reconhecimento Psicológico/fisiologia , Adulto , Feminino , Humanos , MasculinoRESUMO
How spiking activity reverberates through neuronal networks, how evoked and spontaneous activity interacts and blends, and how the combined activities represent external stimulation are pivotal questions in neuroscience. We simulated minimal models of unstructured spiking networks in silico, asking whether and how gentle external stimulation might be subsequently reflected in spontaneous activity fluctuations. Consistent with earlier findings in silico and in vitro, we observe a privileged subpopulation of 'pioneer neurons' that, by their firing order, reliably encode previous external stimulation. We also confirm that pioneer neurons are 'sensitive' in that they are recruited by small fluctuations of population activity. We show that order-based representations rely on a 'chain' of pioneer neurons with different degrees of sensitivity and thus constitute an emergent property of collective dynamics. The forming of such representations is greatly favoured by a broadly heterogeneous connection topology-a broad 'middle class' in degree of connectedness. In conclusion, we offer a minimal model for the representational role of pioneer neurons, as observed experimentally in vitro. In addition, we show that broadly heterogeneous connectivity enhances the representational capacity of unstructured networks.
Assuntos
Potenciais de Ação/fisiologia , Modelos Neurológicos , Rede Nervosa/fisiologia , Neurônios/fisiologia , HumanosRESUMO
When binocular rivalry is induced by opponent motion displays, perceptual reversals are often associated with changed oculomotor behavior (Frässle, Sommer, Jansen, Naber, & Einhäuser, 2014; Fujiwara et al., 2017). Specifically, the direction of smooth pursuit phases in optokinetic nystagmus typically corresponds to the direction of motion that dominates perceptual appearance at any given time. Here we report an improved analysis that continuously estimates perceived motion in terms of "cumulative smooth pursuit." In essence, smooth pursuit segments are identified, interpolated where necessary, and joined probabilistically into a continuous record of cumulative smooth pursuit (i.e., probability of eye position disregarding blinks, saccades, signal losses, and artefacts). The analysis is fully automated and robust in healthy, developmental, and patient populations. To validate reliability, we compare volitional reports of perceptual reversals in rivalry displays, and of physical reversals in nonrivalrous control displays. Cumulative smooth pursuit detects physical reversals and estimates eye velocity more accurately than existing methods do (Frässle et al., 2014). It also appears to distinguish dominant and transitional perceptual states, detecting changes with a precision of ±100 ms. We conclude that cumulative smooth pursuit significantly improves the monitoring of binocular rivalry by means of recording optokinetic nystagmus.
Assuntos
Percepção de Movimento/fisiologia , Nistagmo Optocinético/fisiologia , Acompanhamento Ocular Uniforme/fisiologia , Visão Binocular/fisiologia , Adolescente , Adulto , Criança , Medições dos Movimentos Oculares , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estimulação Luminosa , Reprodutibilidade dos Testes , Movimentos Sacádicos/fisiologia , Adulto JovemRESUMO
When two bi-stable structure-from-motion (SFM) spheres are presented simultaneously, they tend to rotate in the same direction. This effect reflects a common state bias that is present for various multistable displays. However, it was also reported that when two spheres are positioned so that they touch each other, they tend to counterrotate instead. The latter effect is interpreted as a frictional interaction, indicating the influence of the embedded physics on our visual perception. Here, we examined the interplay between these two biases in two experiments using a wide range of conditions. Those included two SFM shapes, two types of disambiguation cues, the presence or absence of the disambiguation cues, different layout options, and two samples of observers from two different universities (in sum 26 participants). Contrary to the prior report, we observed a robust common state bias for all conditions, including those that were optimized for frictional and "gear meshing" interactions. We found that stronger coupling of perceptual states is accompanied by more frequent synchronous perceptual reversals of the two objects. However, we found that the simultaneity of the individual switches does not predict the duration of the following dominance phase. Finally, we report that stronger perceptual coupling speeds up perceptual alternations.
Assuntos
Percepção de Movimento/fisiologia , Rotação , Visão Ocular/fisiologia , Percepção Visual/fisiologia , Adulto , Sinais (Psicologia) , Feminino , Humanos , Masculino , Estimulação Luminosa , Adulto JovemRESUMO
BACKGROUND: Even in resting state, the human brain generates functional signals (fMRI) with complex correlational structure. To simplify this structure, it is common to parcellate a standard brain into coarse chunks. Finer parcellations are considered less reproducible and informative, due to anatomical and functional variability of individual brains. NEW METHODS: Grouping signals with similar local correlation profiles, restricted to each anatomical region (Tzourio-Mazoyer et al., 2002), we divide a standard brain into 758 'functional clusters' averaging 1.7cm3 gray matter volume ('MD758' parcellation). We compare 758 'spatial clusters' of similar size ('S758'). RESULTS: 'Functional clusters' are spatially contiguous and cluster quality (integration and segregation of temporal variance) is far superior to 'spatial clusters', comparable to multi-modal parcellations of half the resolution (Craddock et al., 2012; Glasser et al., 2016). Moreover, 'functional clusters' capture many long-range functional correlations, with O(105) reproducibly correlated cluster pairs in different anatomical regions. The pattern of functional correlations closely mirrors long-range anatomical connectivity established by fibre tracking. COMPARISON TO EXISTING METHODS: MD758 is comparable to coarser parcellations (Craddock et al., 2012; Glasser et al., 2016) in terms of cluster quality, correlational structure (54% relative mutual entropy vs 60% and 61%), and sparseness (35% significant pairwise correlations vs 36% and 44%). CONCLUSION: We describe and evaluate a simple path to finer functional parcellations of the human brain. Detailed correlational structure is surprisingly consistent between individuals, opening new possibilities for comparing functional correlations between cognitive conditions, states of health, or pharmacological interventions.
Assuntos
Mapeamento Encefálico/métodos , Encéfalo/fisiologia , Imageamento por Ressonância Magnética/métodos , Adulto , Feminino , Humanos , Processamento de Imagem Assistida por Computador/métodos , Teoria da Informação , Masculino , Vias Neurais/fisiologia , Adulto JovemRESUMO
UNLABELLED: The timing of perceptual decisions depends on both deterministic and stochastic factors, as the gradual accumulation of sensory evidence (deterministic) is contaminated by sensory and/or internal noise (stochastic). When human observers view multistable visual displays, successive episodes of stochastic accumulation culminate in repeated reversals of visual appearance. Treating reversal timing as a "first-passage time" problem, we ask how the observed timing densities constrain the underlying stochastic accumulation. Importantly, mean reversal times (i.e., deterministic factors) differ enormously between displays/observers/stimulation levels, whereas the variance and skewness of reversal times (i.e., stochastic factors) keep characteristic proportions of the mean. What sort of stochastic process could reproduce this highly consistent "scaling property?" Here we show that the collective activity of a finite population of bistable units (i.e., a generalized Ehrenfest process) quantitatively reproduces all aspects of the scaling property of multistable phenomena, in contrast to other processes under consideration (Poisson, Wiener, or Ornstein-Uhlenbeck process). The postulated units express the spontaneous dynamics of attractor assemblies transitioning between distinct activity states. Plausible candidates are cortical columns, or clusters of columns, as they are preferentially connected and spontaneously explore a restricted repertoire of activity states. Our findings suggests that perceptual representations are granular, probabilistic, and operate far from equilibrium, thereby offering a suitable substrate for statistical inference. SIGNIFICANCE STATEMENT: Spontaneous reversals of high-level perception, so-called multistable perception, conform to highly consistent and characteristic statistics, constraining plausible neural representations. We show that the observed perceptual dynamics would be reproduced quantitatively by a finite population of distinct neural assemblies, each with locally bistable activity, operating far from the collective equilibrium (generalized Ehrenfest process). Such a representation would be consistent with the intrinsic stochastic dynamics of neocortical activity, which is dominated by preferentially connected assemblies, such as cortical columns or clusters of columns. We predict that local neuron assemblies will express bistable dynamics, with spontaneous active-inactive transitions, whenever they contribute to high-level perception.
Assuntos
Modelos Neurológicos , Neurônios/fisiologia , Dinâmica não Linear , Percepção Visual/fisiologia , Potenciais de Ação/fisiologia , Encéfalo/citologia , Encéfalo/fisiologia , Feminino , Humanos , Masculino , Estimulação Luminosa , Processos EstocásticosRESUMO
Retinal input is riddled with abrupt transients due to self-motion, changes in illumination, object-motion, etc. Our visual system must correctly interpret each of these changes to keep visual perception consistent and sensitive. This poses an enormous challenge, as many transients are highly ambiguous in that they are consistent with many alternative physical transformations. Here we investigated inter-trial effects in three situations with sudden and ambiguous transients, each presenting two alternative appearances (rotation-reversing structure-from-motion, polarity-reversing shape-from-shading, and streaming-bouncing object collisions). In every situation, we observed priming of transformations as the outcome perceived in earlier trials tended to repeat in subsequent trials and this repetition was contingent on perceptual experience. The observed priming was specific to transformations and did not originate in priming of perceptual states preceding a transient. Moreover, transformation priming was independent of attention and specific to low level stimulus attributes. In summary, we show how "transformation priors" and experience-driven updating of such priors helps to disambiguate sudden changes of sensory inputs. We discuss how dynamic transformation priors can be instantiated as "transition energies" in an "energy landscape" model of the visual perception.
Assuntos
Atenção/fisiologia , Priming de Repetição/fisiologia , Percepção Visual/fisiologia , Percepção de Forma/fisiologia , Humanos , Percepção de Movimento/fisiologia , Estimulação Luminosa/métodosRESUMO
The timing of certain mental events is thought to reflect random walks performed by underlying neural dynamics. One class of such events--stochastic reversals of multistable perceptions--exhibits a unique scalar property: even though timing densities vary widely, higher moments stay in particular proportions to the mean. We show that stochastic accumulation of activity in a finite number of idealized cortical columns--realizing a generalized Ehrenfest urn model--may explain these observations. Modeling stochastic reversals as the first-passage time of a threshold number of active columns, we obtain higher moments of the first-passage time density. We derive analytical expressions for noninteracting columns and generalize the results to interacting columns in simulations. The scalar property of multistable perception is reproduced by a dynamic regime with a fixed, low threshold, in which the activation of a few additional columns suffices for a reversal.
Assuntos
Modelos Neurológicos , Percepção/fisiologia , Córtex Cerebral/fisiologia , Cognição/fisiologia , Rede Nervosa/fisiologia , Vias Neurais/fisiologia , Neurônios/fisiologia , Processos EstocásticosRESUMO
Perceptual adaptation destabilizes the phenomenal appearance of multistable visual displays. Prolonged dominance of a perceptual state fatigues the associated neural population, lowering the likelihood of renewed perception of the same appearance (Nawrot & Blake in Perception & Psychophysics, 49, 230-44, 1991). Here, we used a selective adaptation paradigm to investigate perceptual adaptation for the illusory rotation of ambiguous structure-from-motion (SFM) displays. Specifically, we generated SFM objects with different three-dimensional shapes and presented them in random order, separating successive objects by brief blank periods, which included a mask. To assess the specificity of perceptual adaptation to the shape of SFM objects, we established the probability that a perceived direction of rotation persisted between successive objects of similar or dissimilar shape. We found that the strength of negative aftereffects depended on the volume, but not the shape, of adaptor and probe objects. More voluminous objects were both more effective as adaptor objects and more sensitive as probe objects. Surprisingly, we found these volume effects to be completely independent, since any relationship between two shapes (such as overlap between volumes, similarity of shape, or similarity of velocity profiles) failed to modulate the negative aftereffect. This pattern of results was the opposite of that observed for sensory memory of SFM objects, which reflects similarity between objects, but not volume of individual objects (Pastukhov et al. in Attention, Perception & Psychophysics, 75, 1215-1229, 2013). The disparate specificities of perceptual adaptation and sensory memory for identical SFM objects suggest that the two aftereffects engage distinct neural representations, consistent with recent brain imaging results (Schwiedrzik et al. in Cerebral Cortex, 2012).
Assuntos
Percepção de Profundidade/fisiologia , Pós-Efeito de Figura/fisiologia , Rememoração Mental/fisiologia , Percepção de Movimento/fisiologia , Visão Binocular/fisiologia , Adaptação Fisiológica/fisiologia , Adulto , Análise de Variância , Atenção , Apresentação de Dados , Feminino , Humanos , Masculino , Movimento (Física) , Estimulação Luminosa/métodos , Psicofísica , Priming de Repetição/fisiologia , Rotação , Disparidade Visual/fisiologiaRESUMO
When multistable displays (stimuli consistent with two or more equally plausible perceptual interpretations) are presented intermittently, their perceptions are stabilized by sensory memory. Independent memory traces are generated not only for different types of multistable displays (Maier, Wilke, Logothetis, & Leopold, Current Biology 13:1076-1085, 2003), but also for different ambiguous features of binocular rivalry (Pearson & Clifford, Journal of Vision 4:196-202, 2004). In the present study, we examined whether a similar independence of sensory memories is observed in structure-from-motion (SFM), a multistable display with two ambiguous properties. In SFM, a 2-D planar motion creates a vivid impression of a rotating 3-D volume. Both the illusory rotation and illusory depth (i.e., how close parts of an object appear to the observer) of an SFM object are ambiguous. We dissociated the sensory memories of these two ambiguous properties by using an intermittent presentation in combination with a forced-ambiguous-switch paradigm (Pastukhov, Vonau, & Braun, PLoS ONE 7:e37734, 2012). We demonstrated that the illusory depth of SFM generates a sensory memory trace that is independent from that of illusory rotation. Despite this independence, the specificities levels of the sensory memories were identical for illusory depth and illusory rotation. The history effect was weakened by a change in the volumetric property of a shape (whether it was a hollow band or a filled drum volume), but not by changes in color or size. We discuss how these new results constrain models of sensory memory and SFM processing.
Assuntos
Percepção de Profundidade/fisiologia , Pós-Efeito de Figura/fisiologia , Ilusões/fisiologia , Memória/fisiologia , Percepção de Movimento/fisiologia , Disparidade Visual/fisiologia , Adaptação Fisiológica , Análise de Variância , Apresentação de Dados , Voluntários Saudáveis , Humanos , Movimento (Física) , Rotação , Interface Usuário-ComputadorRESUMO
Perceptual priming can stabilize the phenomenal appearance of multistable visual displays (Leopold, Wilke, Maier, & Logothetis, Nature Neuroscience, 5, 605-609, 2002). Prior exposure to such displays induces a sensory memory of their appearance, which persists over long intervals and intervening stimulation, and which facilitates renewed perception of the same appearance. Here, we investigated perceptual priming for the apparent rotation in depth of ambiguous structure-from-motion (SFM) displays. Specifically, we generated SFM objects with different three-dimensional shapes and presented them in random order and with intervening blank periods. To assess perceptual priming, we established the probability that a perceived direction of rotation would persist between successive objects. In general, persistence was greatest between identical objects, intermediate between similar objects, and negligible between dissimilar objects. These results demonstrate unequivocally that sensory memory for apparent rotation is specific to three-dimensional shape, contrary to previous reports (e.g., Maier, Wilke, Logothetis, & Leopold, Current Biology, 13, 1076-1085, 2003). Because persistence did not depend on presentation order for any pair of objects, it provides a commutative measure for the similarity of object shapes. However, it is not clear exactly which features or aspects of object shape determine similarity. At least, we did not find simple, low-level features (such as volume overlap, heterogeneity, or rotational symmetry) that could have accounted for all observations. Accordingly, it seems that sensory memory of SFM (which underlies priming of ambiguous rotation) engages higher-level representations of object surface and shape.
Assuntos
Memória/fisiologia , Reconhecimento Visual de Modelos/fisiologia , Percepção Visual/fisiologia , Adaptação Fisiológica/fisiologia , Adulto , Percepção de Profundidade/fisiologia , Feminino , Percepção de Forma/fisiologia , Humanos , Masculino , Movimento (Física) , Percepção de Movimento/fisiologia , Variações Dependentes do Observador , Ilusões Ópticas/fisiologia , Estimulação Luminosa/métodos , Probabilidade , Priming de Repetição/fisiologia , RotaçãoRESUMO
We report that multi-stable perception operates in a consistent, dynamical regime, balancing the conflicting goals of stability and sensitivity. When a multi-stable visual display is viewed continuously, its phenomenal appearance reverses spontaneously at irregular intervals. We characterized the perceptual dynamics of individual observers in terms of four statistical measures: the distribution of dominance times (mean and variance) and the novel, subtle dependence on prior history (correlation and time-constant). The dynamics of multi-stable perception is known to reflect several stabilizing and destabilizing factors. Phenomenologically, its main aspects are captured by a simplistic computational model with competition, adaptation, and noise. We identified small parameter volumes (~3% of the possible volume) in which the model reproduced both dominance distribution and history-dependence of each observer. For 21 of 24 data sets, the identified volumes clustered tightly (~15% of the possible volume), revealing a consistent "operating regime" of multi-stable perception. The "operating regime" turned out to be marginally stable or, equivalently, near the brink of an oscillatory instability. The chance probability of the observed clustering was <0.02. To understand the functional significance of this empirical "operating regime," we compared it to the theoretical "sweet spot" of the model. We computed this "sweet spot" as the intersection of the parameter volumes in which the model produced stable perceptual outcomes and in which it was sensitive to input modulations. Remarkably, the empirical "operating regime" proved to be largely coextensive with the theoretical "sweet spot." This demonstrated that perceptual dynamics was not merely consistent but also functionally optimized (in that it balances stability with sensitivity). Our results imply that multi-stable perception is not a laboratory curiosity, but reflects a functional optimization of perceptual dynamics for visual inference.
RESUMO
We compared the spatial and temporal allocation of attention as revealed by microsaccades. Observers viewed several concurrent "rapid serial visual presentation" (RSVP) streams in the periphery while maintaining fixation. They continually attended to, and discriminated targets in one particular, cued stream. Over and above this continuous allocation, spatial attention transients ("attention shifts") were prompted by changes in the cued stream location and temporal attention transients ("attentional blinks") by successful target discriminations. Note that the RSVP paradigm avoided the preparatory suppression of microsaccades in anticipation of stimulus or task events, which had been prominent in earlier studies. Both stream changes and target discriminations evoked residual modulations of microsaccade rate and direction, which were consistent with the presumed attentional dynamics in each case (i.e., attention shift and attentional blink, respectively). Interestingly, even microsaccades associated with neither stream change nor target discrimination reflected the continuous allocation of attention, inasmuch as their direction was aligned with the meridian of the target stream. We conclude that attentional allocation shapes microsaccadic activity continuously, not merely during dynamic episodes such as attentional shifts or blinks.
Assuntos
Atenção/fisiologia , Movimentos Sacádicos/fisiologia , Percepção Espacial/fisiologia , Percepção do Tempo/fisiologia , Adulto , Discriminação Psicológica , Feminino , Humanos , Masculino , Estimulação Luminosa/métodos , Colículos Superiores/fisiologiaRESUMO
In the structure-from-motion paradigm, physical motion on a screen produces the vivid illusion of an object rotating in depth. Here, we show how to dissociate illusory depth and illusory rotation in a structure-from-motion stimulus using a rotationally asymmetric shape and reversals of physical motion. Reversals of physical motion create a conflict between the original illusory states and the new physical motion: Either illusory depth remains constant and illusory rotation reverses, or illusory rotation stays the same and illusory depth reverses. When physical motion reverses after the interruption in presentation, we find that illusory rotation tends to remain constant for long blank durations (T (blank) ≥ 0.5 s), but illusory depth is stabilized if interruptions are short (T (blank) ≤ 0.1 s). The stability of illusory depth over brief interruptions is consistent with the effect of neural persistence. When this is curtailed using a mask, stability of ambiguous vision (for either illusory depth or illusory rotation) is disrupted. We also examined the selectivity of the neural persistence of illusory depth. We found that it relies on a static representation of an interpolated illusory object, since changes to low-level display properties had little detrimental effect. We discuss our findings with respect to other types of history dependence in multistable displays (sensory stabilization memory, neural fatigue, etc.). Our results suggest that when brief interruptions are used during the presentation of multistable displays, switches in perception are likely to rely on the same neural mechanisms as spontaneous switches, rather than switches due to the initial percept choice at the stimulus onset.
Assuntos
Percepção de Profundidade/fisiologia , Ilusões/fisiologia , Memória/fisiologia , Percepção de Movimento/fisiologia , Feminino , Humanos , Masculino , Rotação , Sensação/fisiologiaRESUMO
Multiple dots moving independently back and forth on a flat screen induce a compelling illusion of a sphere rotating in depth (structure-from-motion). If all dots simultaneously reverse their direction of motion, two perceptual outcomes are possible: either the illusory rotation reverses as well (and the illusory depth of each dot is maintained), or the illusory rotation is maintained (but the illusory depth of each dot reverses). We investigated the role of attention in these ambiguous reversals. Greater availability of attention--as manipulated with a concurrent task or inferred from eye movement statistics--shifted the balance in favor of reversing illusory rotation (rather than depth). On the other hand, volitional control over illusory reversals was limited and did not depend on tracking individual dots during the direction reversal. Finally, display properties strongly influenced ambiguous reversals. Any asymmetries between 'front' and 'back' surfaces--created either on purpose by coloring or accidentally by random dot placement--also shifted the balance in favor of reversing illusory rotation (rather than depth). We conclude that the outcome of ambiguous reversals depends on attention, specifically on attention to the illusory sphere and its surface irregularities, but not on attentive tracking of individual surface dots.