A novel evolutionary strategy revealed in the phaeoviruses.

Phaeoviruses infect the brown algae, which are major contributors to primary production of coastal waters and estuaries. They exploit a Persistent evolutionary strategy akin to a K- selected life strategy via genome integration and are the only known representatives to do so within the giant algal viruses that are typified by r- selected Acute lytic viruses. In screening the genomes of five species within the filamentous brown algal lineage, here we show an unprecedented diversity of viral gene sequence variants especially amongst the smaller phaeoviral genomes. Moreover, one variant shares features from both the two major sub-groups within the phaeoviruses. These phaeoviruses have exploited the reduction of their giant dsDNA genomes and accompanying loss of DNA proofreading capability, typical of an Acute life strategist, but uniquely retain a Persistent life strategy.

Striving for quality use of medicines: how effective is Australia's ban on direct-to-consumer prescription medicine advertising?

The potential for both positive and negative effects arising from direct-to-consumer advertising of prescription medicines challenges health policymakers to develop regulatory schemes which selectively capture the positive aspects of the practice. Australia has dealt with this quandary by banning the practice, while New Zealand and the United States permit it. However, in recent times pharmaceutical companies have been increasingly successful in introducing promotional materials into the Australian market. This article demonstrates that the Australian ban is consistent with striving for the major policy goal of quality use of medicines, thus providing the basis for arguing that solutions to strengthen the ban against the identified threats ought to be implemented. Quality use of medicines can be most effectively achieved via the combined effect of the strengthened ban and the mimicking of the limited positive aspects of direct-to-consumer advertising by government provision of non-promotional information to consumers.

Acoustic and perceptual similarity of Japanese and American English vowels.

Acoustic and perceptual similarities between Japanese and American English (AE) vowels were investigated in two studies. In study 1, a series of discriminant analyses were performed to determine acoustic similarities between Japanese and AE vowels, each spoken by four native male speakers using F1, F2, and vocalic duration as input parameters. In study 2, the Japanese vowels were presented to native AE listeners in a perceptual assimilation task, in which the listeners categorized each Japanese vowel token as most similar to an AE category and rated its goodness as an exemplar of the chosen AE category. Results showed that the majority of AE listeners assimilated all Japanese vowels into long AE categories, apparently ignoring temporal differences between 1- and 2-mora Japanese vowels. In addition, not all perceptual assimilation patterns reflected context-specific spectral similarity patterns established by discriminant analysis. It was hypothesized that this incongruity between acoustic and perceptual similarity may be due to differences in distributional characteristics of native and non-native vowel categories that affect the listeners' perceptual judgments.

Commercialisation of regenerative human tissue: regulation and reform in Australia and England, Wales and Northern Ireland.

The commercialisation of therapeutic products containing regenerative human tissue is regulated by the common law, statute and ethical guidelines in Australia and England, Wales and Northern Ireland. This article examines the regulatory regimes in these jurisdictions and considers whether reform is required to both support scientific research and ensure conformity with modern social views on medical research and the use of human tissue. The authors consider the crucial role of informed consent in striking the balance between the interests of researchers and the interests of the public.

The evolution of integrated passive components in medical devices.

As well as being space saving, integrated passive components offer other opportunities for medical device applications. This article examines their advantages and looks at what the future holds.