RESUMO
BACKGROUND: Anastomotic leakage (AL) is the most frequent life-threating complication following colorectal surgery. Several attempts have been made to prevent AL. This prospective, randomized, multicentre trial aimed to evaluate the safety and efficacy of nebulised modified cyanoacrylate in preventing AL after rectal surgery. METHODS: Patients submitted to colorectal surgery for carcinoma of the high-medium rectum across five high-volume centres between June 2021 and January 2023 entered the study and were randomized into group A (anastomotic reinforcement with cyanoacrylate) and group B (no reinforcement) and followed up for 30 days. Anastomotic reinforcement was performed via nebulisation of 1 mL of a modified cyanoacrylate glue. Preoperative features and intraoperative and postoperative results were recorded and compared. The study was registered at ClinicalTrials.gov (ID number NCT03941938). RESULTS: Out of 152 patients, 133 (control group, n = 72; cyanoacrylate group, n = 61) completed the follow-up. ALs were detected in nine patients (12.5%) in the control group (four grade B and five grade C) and in four patients (6.6%), in the cyanoacrylate group (three grade B and one grade C); however, despite this trend, the differences were not statistically significant (p = 0.36). However, Clavien-Dindo complications grade > 2 were significantly higher in the control group (12.5% vs. 3.3%, p = 0.04). No adverse effects related to the glue application were reported. CONCLUSION: The role of modified cyanoacrylate application in AL prevention remains unclear. However its use to seal colorectal anastomoses is safe and could help to reduce severe postoperative complications.
Assuntos
Anastomose Cirúrgica , Fístula Anastomótica , Cianoacrilatos , Reto , Humanos , Fístula Anastomótica/prevenção & controle , Fístula Anastomótica/etiologia , Feminino , Masculino , Estudos Prospectivos , Idoso , Pessoa de Meia-Idade , Cianoacrilatos/administração & dosagem , Anastomose Cirúrgica/efeitos adversos , Anastomose Cirúrgica/métodos , Reto/cirurgia , Adesivos Teciduais/uso terapêutico , Técnicas de Sutura , Neoplasias Retais/cirurgia , Resultado do TratamentoRESUMO
Inguinal hernias are very common in men. We report a rare case of intestinal perforation following blunt abdominal trauma in a 80-year-old man with pre-existing inguinal hernia. A careful and serial physical examination, with the information obtained from the computed tomography (CT) scan guides the prompt surgical exploration. This case demonstrates that external forces, that may seem too trivial to cause intraperitoneal injury, can cause significant injury when applied to a patient with a hernia. It is possible to repair the intestinal perforation and inguinal hernia in the same operation.