Modification of natural compounds through biotransformation process by microorganisms and their pharmacological properties.

The biotransformation of natural compounds by fungal microorganisms is a complex biochemical process. Tandem whole-cell biotransformation offers a promising, alternative, and cost-effective method for modifying of bioactive novel compounds. This approach is particularly beneficial for structurally complex natural products that are difficult to be synthesize, through total chemical synthesis. Biotransformation also provides significant regio- and stereoselectivity, making it a valuable tool for the chemical modification of natural compounds. By utilizing microbial conversion reactions, the biological activity and structural diversity of natural products can be enhanced. In this review, we have summarize 282 novel metabolites resulting from microbial transformation by various microorganisms. We discuss the chemical structures and pharmacological properties of these novel biotransformation products. The review aims to assist scientists working in the fields of biotechnology, organic chemistry, medicinal chemistry, and pharmacology.