1.
J Org Chem
; 84(23): 15106-15117, 2019 12 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31553875
RESUMO
A practical synthetic approach to the difluoro-substituted bicyclo[1.1.1]pentanes was developed. The key step was an addition of difluorocarbene (:CF2) to electron-rich bicyclo[1.1.0]butanes by the CF3TMS/NaI system. The obtained difluoro-bicyclo[1.1.1]pentanes are suggested to be used as saturated bioisosteres of benzene rings for the purpose of drug discovery projects.
2.
Chemistry
; 24(47): 12291-12297, 2018 Aug 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29419903
RESUMO
Difluorocyclopropane-containing building blocks for drug discovery were synthesized from the functionalized alkenes and TMSCF3 /NaI. Novel fluorinated acids, amines, amino acids, alcohols, ketones and sulfonyl chlorides were obtained.