Neuroprotective effects of Nigella sativa on experimental spinal cord injury in rats.

The aim of this study was to investigate the possible beneficial effects of Nigella sativa (NS) in comparison to methylprednisolone on experimental spinal cord injury (SCI) in rats. SCI was performed by placing an aneurysm clip extradurally at the level of T11-12. Rats were neurologically tested over 24 h after trauma and spinal cord tissue samples were harvested for both biochemical and histopathological evaluation. The neurological scores of rats were not found to be different in SCI groups. SCI significantly increased the spinal cord tissue malondialdehyde (MDA) and protein carbonyl (PC) levels, however SCI decreased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) enzyme activities compared to the control. Methylprednisolone and NS treatment decreased tissue MDA and PC levels and prevented inhibition of SOD, GSH-Px and CAT enzymes in the tissues. The most significant results were obtained when NS was given. In SCI and placebo groups, the neurons of spinal cord tissue became extensively dark and degenerated with picnotic nuclei. The morphology of neurons in methylprednisolone and NS-treated groups were well protected, however, not as well as the neurons of the control group. The number of neurons in the spinal cord tissue of the SCI and placebo groups was significantly less than the control, laminectomy, methylprednisolone and NS-treated groups. In conclusion, NS treatment might be beneficial in spinal cord tissue damage, and therefore shows potential for clinical implications.

Neurocutaneous melanosis associated with Dandy-Walker malformation.

Neurocutaneous melanosis is an uncommon congenital disorder consisting of benign or malignant melanocytic tumors of the leptomeninges with large or numerous cutaneous congenital melanocytic nevi. The Dandy-Walker malformation occurs as an enlarged posterior fossa with high insertion of the tentorium, hypoplasia or aplasia of the cerebellar vermis, and cystic dilatation of the fourth ventricle. To our knowledge, the association of these two conditions has been reported only 14 times. In this article, we present a newborn patient with neurocutaneous melanosis associated with Dandy-Walker malformation, which was diagnosed by magnetic resonance imaging.

Intramedullary spinal cord metastases: diagnosis and treatment - an illustrated review.

BACKGROUND: Intramedullary spinal cord metastases (ISCM) are rare but, with increasing use of magnetic resonance imaging (MRI) are being encountered with increasing frequency. Optimum treatment remains controversial. On the basis of a review of previous reports and experience with a patient with an ISCM from a large cell lung cancer, we propose practical diagnostic and therapeutic approaches. FINDINGS: We found 284 patients who had an Intramedullary spinal cord metastasis reported in English literature up to February 2004. 32 had been treated surgically. The mean survival in these patients was two times longer than in those treated by a conservative approach. Improvement and prolonged survival occurred in patient we treated by microsurgical dissection of the metastasis. CONCLUSION: Early diagnosis and early surgical resection can result in improvement in neurological deficits and in the quality of life of patients with a Intramedullary spinal cord metastasis.

WITHDRAWN: Microsurgical resection of intramedullary spinal cord metastases of large cell lung cancer.

This article has now been withdrawn and will not appear in print.

Effect of hydrophilic coating on microorganism colonization in silicone tubing.

BACKGROUND: Shunt infections are one of the major causes of mortality and morbidity of patients with hydrocephalus. The aim of this research is to compare the bacterial colonization characteristics of a regular silicone elastomer shunt material coated with polyvinylpyrrolidone and dimethylpolysiloxane (silicone). METHOD: Regular coated shunt materials were compared by in-vivo and in-vitro methods. In the in-vitro experiment, silicone and coated material immersed and not immersed in vancomycin solution was treated with a certain concentration of Staphylococcus epidermidis. In the in-vivo study, silicone and coated material specimens were treated with Staphylococcus epidermidis and they were stereotactically placed in the lateral ventricles of the rats. One week after the inoculation, shunt pieces were removed and the colonies were counted by using a scanning electron microscope. FINDINGS: There was a statistically significant difference of colonization in the in-vitro groups in coated material vs. silicone, coated material vs. vancomycin treated silicone, vancomycin treated coated material vs. silicone, vancomycin treated coated material vs. vancomycin treated silicone. There was no statistically significant difference for colonization in in-vitro groups of coated material and vancomycin treated coated material. With in-vivo experiments we can say that, coated material catheters are superior than the silicone catheters in respect to colonization but after the bacterial colonization has occurred, the amount of colonization did not differ. INTERPRETATION: Coated material catheters are superior to silicone catheters and they prevent bacterial colonization in some respect.

Unilateral cervical facet fracture: presentation of two cases and literature review.

STUDY DESIGN: Two patients with diagnosis of unilateral cervical facet fracture due to motor vehicle accident (MVA) are presented, and the literature is reviewed. OBJECTIVE: To discuss the diagnostic difficulties and management strategies in two patients with post-traumatic cervical facet fracture. SETTING: Department of Neurosurgery, Zonguldak Karaelmas University, Faculty of Medicine, Turkey. SUBJECT: Nonoperative treatment with immobilization was preferred in two female cases (33-34 years old) with diagnosis of C6-7 facet fracture following MVA. Magnetic resonance imaging (MRI) could be performed in acute period in the first case, but not in the second because of inadequate technical condition. RESULT: The first case with a good compliance to immobilization recovered without any neurological complication. However, the second case mobilized earlier and used a collar irregularly. Instability developed in the second case on the second month and surgical intervention with anterior approach was performed. CONCLUSION: The diagnosis of unilateral facet fractures is often missed and the treatment is still controversial. The compliance of the patient to cervical immobilization in nonoperative treatment plays a very important role in the development of late complications. MRI in the acute period may be useful in determining instability.

Migration of pacemaker lead into the spinal venous plexus: case report with special reference to Batson's theory of spinal metastasis.

OBJECTIVE AND IMPORTANCE: Migration of a foreign material via venous routes into the spinal canal is a very rare incidence. We report the second case in which a foreign body has migrated into the spinal canal via the venous route. CLINICAL PRESENTATION: This 35-years-old man presented with sudden onset of severe low back pain and pain in the right leg four months after an unsuccessful attempt to remove a disconnected cardiac pacemaker lead via the femoral vein. Direct lumbar x-ray demonstrated the broken lead of the cardiac pacemaker at the entrance of the right L5 foramen which was also demonstrated by lumbar CT. SURGICAL INTERVENTION: After right L5 hemilaminotomy, the pacemaker lead was found in a vein of the anterior spinal venous plexus just beneath and lateral to the right L5 root. After dissecting it from the surrounding adipose tissue, the embolised pacemaker lead was taken out. CONCLUSION: We present a case report and review of the literature on migration of foreign material into the spinal canal, factors effecting the flow directions in the spinal veins. This case may be the first evidence that proved Batson's theory of spinal metastases in man.