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Int Immunopharmacol ; 38: 402-8, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27355133

RESUMO

Ortho-eugenol is a much used phenylpropanoid whose ability to reduce pain and inflammation has never been studied. Researching ortho-eugenol's antinociceptive and anti-inflammatory activity, and its possible mechanisms of action is therefore of interest. The administration of vehicle, ortho-eugenol (50, 75 and 100mg/kg i.p.), morphine (6mg/kg, i.p.) or dexamethasone (2mg/kg, s.c.) occurred 30min before the completion of pharmacological tests. Pretreatment with ortho-eugenol did not change motor coordination test results, but reduced the number of writhes and licking times in the writhing test and glutamate test, respectively. The reaction time from thermal stimulus was significantly increased in the hot plate test after administration of ortho-eugenol. Treatment with yohimbine reversed the antinociceptive effect of ortho-eugenol, suggesting involvement of the adrenergic system. In anti-inflammatory tests, ortho-eugenol inhibited acetic acid induced vascular permeability and leukocyte migration, reducing TNF-α and IL-1ß by virtue of its suppression of NF-κB and p38 phosphorylated forms in the peritonitis test. From these results, ortho-eugenol antinociceptive effects mediated by the adrenergic system and anti-inflammatory activity through regulation of proinflammatory cytokines and phosphorylation of NF-kB and p38 become evident for the first time.


Assuntos
Analgésicos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Eugenol/uso terapêutico , Leucócitos/efeitos dos fármacos , Atividade Motora , Dor/tratamento farmacológico , Antagonistas de Receptores Adrenérgicos alfa 2/administração & dosagem , Animais , Permeabilidade Capilar/efeitos dos fármacos , Movimento Celular/efeitos dos fármacos , Eugenol/química , Temperatura Alta/efeitos adversos , Interleucina-1beta/metabolismo , Leucócitos/fisiologia , Masculino , Camundongos , Atividade Motora/efeitos dos fármacos , NF-kappa B/metabolismo , Fator de Necrose Tumoral alfa/metabolismo , Ioimbina/administração & dosagem , Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
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