Injectable Self-Expanding/Self-Propelling Hydrogel Adhesive with Procoagulant Activity and Rapid Gelation for Lethal Massive Hemorrhage Management.

Developing hydrogels that can quickly reach deep bleeding sites, adhere to wounds, and expand to stop lethal and/or noncompressible bleeding in civil and battlefield environments remains a challenge. Herein, an injectable, antibacterial, self-expanding, and self-propelling hydrogel bioadhesive with procoagulant activity and rapid gelation is reported. This hydrogel combines spontaneous gas foaming and rapid Schiff base crosslinking for lethal massive hemorrhage. Hydrogels have rapid gelation and expansion rate, high self-expanding ratio, excellent antibacterial activity, antioxidant efficiency, and tissue adhesion capacity. In addition, hydrogels have good cytocompatibility, procoagulant ability, and higher blood cell/platelet adhesion activity than commercial combat gauze and gelatin sponge. The optimized hydrogel (OD-C/QGQL-A30) exhibits better hemostatic ability than combat gauze and gelatin sponge in rat liver and femoral artery bleeding models, rabbit volumetric liver loss massive bleeding models with/without anticoagulant, and rabbit liver and kidney incision bleeding models with bleeding site not visible. Especially, OD-C/QGQL-A30 rapidly stops the bleedings from pelvic area of rabbit, and swine subclavian artery vein transection. Furthermore, OD-C/QGQL-A30 has biodegradability and biocompatibility, and accelerates Methicillin-resistant S. aureus (MRSA)-infected skin wound healing. This injectable, antibacterial, self-expanding, and self-propelling hydrogel opens up a new avenue to develop hemostats for lethal massive bleeding, abdominal organ bleeding, and bleeding from coagulation lesions.

Recent progress of antibacterial hydrogels in wound dressings.

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar to human soft tissue extracellular matrix, and tissue repair properties. In skin wound repair, hydrogels with antibacterial functions are especially suitable for dressing applications, so novel antibacterial hydrogel wound dressings have attracted widespread attention, including the design of components, optimization of preparation methods, strategies to reduce bacterial resistance, etc. In this review, we discuss the fabrication of antibacterial hydrogel wound dressings and the challenges associated with the crosslinking methods and chemistry of the materials. We have investigated the advantages and limitations (antibacterial effects and antibacterial mechanisms) of different antibacterial components in the hydrogels to achieve good antibacterial properties, and the response of hydrogels to stimuli such as light, sound, and electricity to reduce bacterial resistance. Conclusively, we provide a systematic summary of antibacterial hydrogel wound dressings findings (crosslinking methods, antibacterial components, antibacterial methods) and an outlook on long-lasting antibacterial effects, a broader antibacterial spectrum, diversified hydrogel forms, and the future development prospects of the field.

Spider Web-Inspired Lightweight Membrane-Type Acoustic Metamaterials for Broadband Low-Frequency Sound Isolation.

Membrane-type acoustic metamaterial (MAM) has exhibited superior sound isolation properties, as well as thin and light characteristics. However, the anti-resonance modes of traditional MAMs are generated intermittently in a wide frequency range causing discontinuities in the anti-resonance modes. Achieving broadband low-frequency sound attenuation with lightweight MAM design is still a pivotal research aspect. Here, we present a strategy to realize wide sound-attenuation bands in low frequency range by introducing the design concept of bionic configuration philosophy into the MAM structures. Built by a polymeric membrane and a set of resonators, two kinds of MAM models are proposed based on the insight of a spider web topology. The sound attenuation performance and physical mechanisms are numerically and experimentally investigated. Multi-state anti-resonance modes, induced by the coupling of the bio-inspired arrangement and the host polymer film, are systematically explored. Significant sound attenuation is numerically and experimentally observed in both the lightweight bio-inspired designs. Remarkably, compared with a traditional MAM configuration, a prominent enhancement in both attenuation bandwidth and weight-reduction performance is verified. In particular, the bio-inspired MAM Model I exhibits a similar isolation performance as the reference model, but the weight is reduced by nearly half. The bio-inspired Model II broadens the sound attenuation bandwidth greatly; meanwhile, it retains a lighter weight design. The proposed bio-inspired strategies provide potential ways for designing sound isolation devices with both high functional and lightweight performance.